IT1163958B - 4-Aryl-5-aminoalkyl-1,3-dioxolone derivs. - with hypolipaemic, antiulcer, antihistamine and anti-serotonin activity - Google Patents
4-Aryl-5-aminoalkyl-1,3-dioxolone derivs. - with hypolipaemic, antiulcer, antihistamine and anti-serotonin activityInfo
- Publication number
- IT1163958B IT1163958B IT4800479A IT4800479A IT1163958B IT 1163958 B IT1163958 B IT 1163958B IT 4800479 A IT4800479 A IT 4800479A IT 4800479 A IT4800479 A IT 4800479A IT 1163958 B IT1163958 B IT 1163958B
- Authority
- IT
- Italy
- Prior art keywords
- hypolipaemic
- dioxolone
- derivs
- antihistamine
- aryl
- Prior art date
Links
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 title abstract 2
- 230000001387 anti-histamine Effects 0.000 title abstract 2
- 230000000794 anti-serotonin Effects 0.000 title abstract 2
- 230000000767 anti-ulcer Effects 0.000 title abstract 2
- 239000000739 antihistaminic agent Substances 0.000 title abstract 2
- 239000003420 antiserotonin agent Substances 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 230000000055 hyoplipidemic effect Effects 0.000 title abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- BXNKCKFDLBMOTA-UHFFFAOYSA-N dioxol-3-one Chemical compound O=C1C=COO1 BXNKCKFDLBMOTA-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Dioxolone derivs. of formula (I) and their salts are new: (where Ar is an opt. substd. mono- or polynuclear aryl gp. A is 1-3C alkylene, Z is O or S, and Nr1R2 is the residue of a sec. amine, e.g. a N,N-dialkylamine, N-cycloalkyl-N-alkylamine, N-alkyl-N-phenylalkylamine, opt. substd. N,N-alkylenimine or an opt. substd. oxa-, thia- or azaalkylenimine). (I) have hypolipaemic, anti-ulcer, antihistamine and antiserotonin activity, e.g. giving 30% redn. in plasma cholesterol and triglyceride levels at a dose of 6-100 mg/kg (p.o. rat).
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT4800479A IT1163958B (en) | 1979-02-14 | 1979-02-14 | 4-Aryl-5-aminoalkyl-1,3-dioxolone derivs. - with hypolipaemic, antiulcer, antihistamine and anti-serotonin activity |
AU44404/79A AU518565B2 (en) | 1978-03-03 | 1979-02-20 | 4-aryl-5-aminoalkyl-1,3-dioxol-2-ones 0 |
CH182579A CH639970A5 (en) | 1978-03-03 | 1979-02-23 | 4-ARIL-5-AMINOALKYL-1,3-DIOXOL-2-ONI, THEIR SALTS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
CA000322408A CA1158242A (en) | 1978-03-03 | 1979-02-27 | 4-aryl-5-aminoalkyl-1, 3-dioxol-2-ones, their derivatives, processes for their preparation and pharmaceutical compositions containing them |
FR7904928A FR2418796A1 (en) | 1978-03-03 | 1979-02-27 | 4-ARYL-5-AMINOALKYL-1,3-DIOXOL-2-ONES, THEIR DERIVATIVES, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
NLAANVRAGE7901583,A NL177404C (en) | 1978-03-03 | 1979-02-28 | 4-ARYL-5-AMINOALKYL-1,3-DIOXOLONES, THEIR PHARMACEUTICALLY SUITABLE SALTS, PROCESS FOR THEIR PREPARATION, AND MEDICINAL PRODUCTS WITH THESE DIOXOLONES OR THEIR SALTS AS THE ACTIVE SUBSTANCES THEREIN. |
US06/016,135 US4235904A (en) | 1978-03-03 | 1979-03-01 | 4-Aryl-5-piperazinoalkyl-1,3-dioxol-2-ones, and compositions |
ES478696A ES478696A1 (en) | 1978-03-03 | 1979-03-02 | 4-Aryl-5-piperazinoalkyl-1,3-dioxol-2-ones, and compositions |
DE2908148A DE2908148C2 (en) | 1978-03-03 | 1979-03-02 | 4-Aryl-5- [2- (4-phenyl-1-piperazinyl) -ethyl] -1,3-dioxol-2-ones, processes for their preparation and pharmaceuticals containing these compounds |
PT69302A PT69302A (en) | 1978-03-03 | 1979-03-02 | Process for preparing 4-aryl-5-aminoalkyl-1,3-dioxol-2-ones their derivatives compositions containing them |
JP2500479A JPS54130569A (en) | 1978-03-03 | 1979-03-03 | 44aryll55aminoalkyll1*33dioxoll22ones*their derivatives or salts*their manufacture and hypocholesterolemic*hypolipemic*antiulcer* antihistamic or antiserotonic drug as active component of said compoun |
GB7907651A GB2017684B (en) | 1978-03-03 | 1979-03-05 | Dioxolones |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT4800479A IT1163958B (en) | 1979-02-14 | 1979-02-14 | 4-Aryl-5-aminoalkyl-1,3-dioxolone derivs. - with hypolipaemic, antiulcer, antihistamine and anti-serotonin activity |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7948004A0 IT7948004A0 (en) | 1979-02-14 |
IT1163958B true IT1163958B (en) | 1987-04-08 |
Family
ID=11263907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT4800479A IT1163958B (en) | 1978-03-03 | 1979-02-14 | 4-Aryl-5-aminoalkyl-1,3-dioxolone derivs. - with hypolipaemic, antiulcer, antihistamine and anti-serotonin activity |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1163958B (en) |
-
1979
- 1979-02-14 IT IT4800479A patent/IT1163958B/en active
Also Published As
Publication number | Publication date |
---|---|
IT7948004A0 (en) | 1979-02-14 |
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