IT1104165B - Carnitine compsn. as the racemate or optical isomers - is used to treat hyperlipaemia, hypercholesterolaemia and associated lipid metabolism defects - Google Patents

Carnitine compsn. as the racemate or optical isomers - is used to treat hyperlipaemia, hypercholesterolaemia and associated lipid metabolism defects

Info

Publication number
IT1104165B
IT1104165B IT4790078A IT4790078A IT1104165B IT 1104165 B IT1104165 B IT 1104165B IT 4790078 A IT4790078 A IT 4790078A IT 4790078 A IT4790078 A IT 4790078A IT 1104165 B IT1104165 B IT 1104165B
Authority
IT
Italy
Prior art keywords
carnitine
compsn
hyperlipaemia
hypercholesterolaemia
racemate
Prior art date
Application number
IT4790078A
Other languages
Italian (it)
Other versions
IT7847900A0 (en
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Publication of IT7847900A0 publication Critical patent/IT7847900A0/en
Priority to IT4790078A priority Critical patent/IT1104165B/en
Priority to DE19792903579 priority patent/DE2903579A1/en
Priority to DE2903558A priority patent/DE2903558C2/en
Priority to CA000320784A priority patent/CA1136551A/en
Priority to BE193254A priority patent/BE873915A/en
Priority to CH106179A priority patent/CH640413A5/en
Priority to NL7900872A priority patent/NL7900872A/en
Priority to GB7903649A priority patent/GB2013495A/en
Priority to ZA79450A priority patent/ZA79450B/en
Priority to NL7900871A priority patent/NL7900871A/en
Priority to ZA79449A priority patent/ZA79449B/en
Priority to BE193251A priority patent/BE873912A/en
Priority to GB7903650A priority patent/GB2013496B/en
Priority to CH106279A priority patent/CH640414A5/en
Priority to JP1171779A priority patent/JPS54113442A/en
Priority to JP1171679A priority patent/JPS54113409A/en
Priority to US06/083,418 priority patent/US4255449A/en
Priority to US06/165,351 priority patent/US4268524A/en
Application granted granted Critical
Publication of IT1104165B publication Critical patent/IT1104165B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms

Abstract

Compsns. contain D,L-carnitine, D-carnitine, L-carnitine or their salts, esters or amides in an effective quantity to reestablish normal metabolism and a pharmaceutical vehicle or support. Unlike known compsns. the present compsn. is free from undesirable side-effects. The compsns. are administered orally or parenterally in daily doses of 10-50 mg/kg of active cpd. Animal tests and clinical trials are described.
IT4790078A 1978-02-03 1978-02-03 Carnitine compsn. as the racemate or optical isomers - is used to treat hyperlipaemia, hypercholesterolaemia and associated lipid metabolism defects IT1104165B (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT4790078A IT1104165B (en) 1978-02-03 1978-02-03 Carnitine compsn. as the racemate or optical isomers - is used to treat hyperlipaemia, hypercholesterolaemia and associated lipid metabolism defects
DE19792903579 DE2903579A1 (en) 1978-02-03 1979-01-31 USE OF ACETYL CARNITINE AND OTHER ACYLDER DERIVATIVES OF CARNITINE FOR THE TREATMENT OF HYPERLIPOPROTEINEMIC AND HYPERLIMPIDAEMIA AND MEDICINAL PRODUCTS
DE2903558A DE2903558C2 (en) 1978-02-03 1979-01-31 Use of L-carnitine
ZA79450A ZA79450B (en) 1978-02-03 1979-02-02 Use of acetyl carnitine and other acyl derivatives of carnitine for treating hyperlipoproteinaemias and hyperlipidaemias
GB7903650A GB2013496B (en) 1978-02-03 1979-02-02 Treating hyperlipoproteinaemias and hyperlipidaemias
CH106179A CH640413A5 (en) 1978-02-03 1979-02-02 PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF HYPERLIPOPROTEINEMIE.
NL7900872A NL7900872A (en) 1978-02-03 1979-02-02 METHOD OF TREATING HYPERLIPOPROTEINEMIA AND HYPERLIPIDEMIA.
GB7903649A GB2013495A (en) 1978-02-03 1979-02-02 Therapeutic method for the treatment of hyperlipodaemias and hyperlipoproteinaemias
CA000320784A CA1136551A (en) 1978-02-03 1979-02-02 Composition containing acetyl carnitine and other acyl derivatives of carnitine for treating hyperlipoproteinaemias and hyperlipidaemias
NL7900871A NL7900871A (en) 1978-02-03 1979-02-02 PROCEDURE FOR THE THERAPEUTIC TREATMENT OF HYPERLIPIDEMIA AND HYPERLIPI PROTEINEMIA.
ZA79449A ZA79449B (en) 1978-02-03 1979-02-02 Therapeutic method for the treatment of hyperlipoproteinaemias and hyperlipodaemias
BE193251A BE873912A (en) 1978-02-03 1979-02-02 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HYPERLIPOIDEMIA AND HYPERLIPOPROTEINEMIA
BE193254A BE873915A (en) 1978-02-03 1979-02-02 USE OF ACETYL CARNITINE AND OTHER ACYL CARNITINE DERIVATIVES IN THE TREATMENT OF HYPERLIPOPROTEINEMIA AND HYPERLIPIDEMIA
CH106279A CH640414A5 (en) 1978-02-03 1979-02-02 THERAPEUTIC PREPARATION FOR THE TREATMENT OF HYPERLIPOPROTEINEMIE, DYSLIPEMIA AND RELATED DISEASES.
JP1171779A JPS54113442A (en) 1978-02-03 1979-02-03 Treating agent of hyperlipoid disease
JP1171679A JPS54113409A (en) 1978-02-03 1979-02-03 Treating agent for hyperlipoid disease
US06/083,418 US4255449A (en) 1978-02-03 1979-10-10 Method of treating abnormal lipoprote in ratios
US06/165,351 US4268524A (en) 1978-02-03 1980-07-02 Method of treating abnormal lipoprotein ratios with acylcarnitine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT4790078A IT1104165B (en) 1978-02-03 1978-02-03 Carnitine compsn. as the racemate or optical isomers - is used to treat hyperlipaemia, hypercholesterolaemia and associated lipid metabolism defects

Publications (2)

Publication Number Publication Date
IT7847900A0 IT7847900A0 (en) 1978-02-03
IT1104165B true IT1104165B (en) 1985-10-21

Family

ID=11263225

Family Applications (1)

Application Number Title Priority Date Filing Date
IT4790078A IT1104165B (en) 1978-02-03 1978-02-03 Carnitine compsn. as the racemate or optical isomers - is used to treat hyperlipaemia, hypercholesterolaemia and associated lipid metabolism defects

Country Status (3)

Country Link
BE (2) BE873912A (en)
IT (1) IT1104165B (en)
ZA (2) ZA79449B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1156769B (en) * 1978-05-25 1987-02-04 Sigma Tau Ind Farmaceuti THERAPEUTIC APPLICATION OF CARNITINE AND OTHER ACIL DERIVATIVES OF CARNITINE

Also Published As

Publication number Publication date
ZA79450B (en) 1980-02-27
ZA79449B (en) 1980-02-27
BE873915A (en) 1979-05-29
BE873912A (en) 1979-05-29
IT7847900A0 (en) 1978-02-03

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961216