IT1060876B - Aryl-oxazole derivs - anti-inflammatory agents
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Aryl-oxazole derivs - anti-inflammatory agents
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Publication number
IT1060876B
IT1060876BIT2286567AIT2286567AIT1060876BIT 1060876 BIT1060876 BIT 1060876BIT 2286567 AIT2286567 AIT 2286567AIT 2286567 AIT2286567 AIT 2286567AIT 1060876 BIT1060876 BIT 1060876B
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Priority claimed from GB51823/66Aexternal-prioritypatent/GB1145884A/en
Priority claimed from GB5620366Aexternal-prioritypatent/GB1206403A/en
Application filed by American Home ProdfiledCriticalAmerican Home Prod
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Publication of IT1060876BpublicationCriticalpatent/IT1060876B/en
(A) Pharmaceutical compositions comprising as active ingredient a compound of formula: (I) or an acid addition salt thereof. The 2-position contains one of the groups R' or R2; R' = opt. substd. aryl or heteroaryl; R2=saturated or olefinic aliphatic acid ( is not C2) or a salt, ester, amide or hydroxamic acid deriv. thereof; R3 = H, alkyl (C1-C4). (B) Compounds of formula I provided that when R' is unsubstd. phenyl in the 2-position and when R2 is n-propionic acid or acrylic acid residue in the 4-position, R3 in the 5-position is alkyl (C1-C4). Anti-inflammatory activity. beta-(4-phenyloxazol-2-yl) propionic acid.