IT1047895B - 1,3-benzodioxol-2-yl alkanoic acid and amide derivs - -antiinflammatories, analgesics, antipyretics, antitussives, cns-depr - Google Patents

Abstract

Novel title cpds. have formula: (where R=H, lower-alkyl (opt. substd. by halo or hydroxy), aryl, aralkyl (opt. ring substd. by halo, alkyl, hydroxy or alkoxy) Alk=straight, branched or cyclic opt. unsaturated alkyl or R may be joined to Alk to form a spiran cpd. R1 = H, halo, opt. halosubstd. lower alkyl, hydroxy, nitro, opt. substd. amino or may represent a benzene ring condensed with benzodioxole ring R2 = -OR3 or -NR4R5 R3 = H, straight or branched alkyl, hydroxyalkyl, aralkyl, aminoalkyl, aminoalkoxyalkyl (the amine gp. being free, mono- or di-substd. by lower alkyl gps. or forming part of a heterocyclic gp.) R4, R5 = same or different H, straight, branched or cyclic lower alkyl, hydroxyalkyl, aralkyl, aminoalkyl (in which the amine gp. is free, mono- or di-substd. by alkyl gps.) or may form part of a heterocyclic ring), hydroxy, acyloxy, aryl (opt. substd. by halo or alkyl gps.) or together with the N atom form a heterocyclic ring with the conditions that (a) when R = CH3 and R1 = H or 5-CH3, Alk COR2 is not carboxymethyl, 2-carboxyethyl, 1-methyl-2-carboxyethyl, 2-carboxy-propyl or the corresponding ethylesters (b) when R = CH3 and R1 = 5-NO2 Alk COR2 is not carboxymethyl or the corresponding ethyl ester (c) when R = phenyl and R1=h Alk cor2 is not carboxymethyl or carbomethyoxymethyl and (d) when R and R1 = H the Alk-CO-R2 is not -CH2CONH2) including their salts and stereocoomers.