IN2015DN03203A - - Google Patents
Info
- Publication number
- IN2015DN03203A IN2015DN03203A IN3203DEN2015A IN2015DN03203A IN 2015DN03203 A IN2015DN03203 A IN 2015DN03203A IN 3203DEN2015 A IN3203DEN2015 A IN 3203DEN2015A IN 2015DN03203 A IN2015DN03203 A IN 2015DN03203A
- Authority
- IN
- India
- Prior art keywords
- binding agent
- impurities
- mixture
- cytotoxic agent
- cell
- Prior art date
Links
- 239000011230 binding agent Substances 0.000 abstract 3
- 229940127089 cytotoxic agent Drugs 0.000 abstract 3
- 239000002254 cytotoxic agent Substances 0.000 abstract 3
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 3
- 239000012535 impurity Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261709871P | 2012-10-04 | 2012-10-04 | |
| PCT/US2013/063503 WO2014055893A1 (en) | 2012-10-04 | 2013-10-04 | Use of an ion exchange membrane to remove impurities from cell-binding agent cytotoxic agent conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN03203A true IN2015DN03203A (cs) | 2015-10-02 |
Family
ID=50435480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN3203DEN2015 IN2015DN03203A (cs) | 2012-10-04 | 2013-10-04 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20150307596A1 (cs) |
| EP (1) | EP2903450A4 (cs) |
| JP (1) | JP2015535215A (cs) |
| CN (1) | CN105208876A (cs) |
| AU (1) | AU2013326897A1 (cs) |
| CA (1) | CA2886996A1 (cs) |
| HK (1) | HK1213148A1 (cs) |
| IL (1) | IL238111A0 (cs) |
| IN (1) | IN2015DN03203A (cs) |
| MX (1) | MX2015004258A (cs) |
| RU (1) | RU2015116883A (cs) |
| SG (1) | SG11201502430QA (cs) |
| WO (1) | WO2014055893A1 (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5350792B2 (ja) | 2005-08-24 | 2013-11-27 | イムノゲン インコーポレーティッド | メイタンシノイド（ｍａｙｔａｎｓｉｎｏｉｄ）抗体複合体の調製方法 |
| LT2437790T (lt) | 2009-06-03 | 2019-06-10 | Immunogen, Inc. | Konjugavimo būdai |
| DK2691155T3 (en) | 2011-03-29 | 2019-03-04 | Immunogen Inc | PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A STEP PROCEDURE |
| IN2015DN03202A (cs) * | 2012-10-04 | 2015-10-02 | Immunogen Inc | |
| GB201616758D0 (en) * | 2016-10-03 | 2016-11-16 | Ge Healthcare Bio Sciences Ab | Novel chromatography media |
| CN108549763B (zh) * | 2018-04-09 | 2021-06-01 | 电子科技大学 | 一种用于离子推进器数值模拟的电荷交换碰撞mcc方法 |
| CN118290513B (zh) * | 2024-06-05 | 2025-03-14 | 东曜药业有限公司 | 一种去除抗体偶联药物中游离小分子的阴离子柱层析方法及抗体偶联药物 |
| CN118290514B (zh) * | 2024-06-05 | 2025-04-04 | 东曜药业有限公司 | 基于阴离子膜的抗体偶联药物的纯化方法及抗体偶联药物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1467758A4 (en) * | 2002-01-03 | 2007-11-14 | Smithkline Beecham Corp | PREPARATION OF IMMUNOCONJUGATES |
| US20090068178A1 (en) * | 2002-05-08 | 2009-03-12 | Genentech, Inc. | Compositions and Methods for the Treatment of Tumor of Hematopoietic Origin |
| US20110166319A1 (en) * | 2005-02-11 | 2011-07-07 | Immunogen, Inc. | Process for preparing purified drug conjugates |
| EP1853322B1 (en) * | 2005-02-11 | 2014-06-25 | ImmunoGen, Inc. | Process for preparing maytansinoid antibody conjugates |
| JP5350792B2 (ja) * | 2005-08-24 | 2013-11-27 | イムノゲン インコーポレーティッド | メイタンシノイド（ｍａｙｔａｎｓｉｎｏｉｄ）抗体複合体の調製方法 |
| LT2437790T (lt) * | 2009-06-03 | 2019-06-10 | Immunogen, Inc. | Konjugavimo būdai |
| DK2691155T3 (en) * | 2011-03-29 | 2019-03-04 | Immunogen Inc | PREPARATION OF MAYTANSINOID ANTIBODY CONJUGATES BY A STEP PROCEDURE |
-
2013
- 2013-10-04 RU RU2015116883A patent/RU2015116883A/ru not_active Application Discontinuation
- 2013-10-04 SG SG11201502430QA patent/SG11201502430QA/en unknown
- 2013-10-04 MX MX2015004258A patent/MX2015004258A/es unknown
- 2013-10-04 CA CA 2886996 patent/CA2886996A1/en not_active Abandoned
- 2013-10-04 HK HK16101358.6A patent/HK1213148A1/zh unknown
- 2013-10-04 EP EP13843881.7A patent/EP2903450A4/en not_active Withdrawn
- 2013-10-04 WO PCT/US2013/063503 patent/WO2014055893A1/en active Application Filing
- 2013-10-04 US US14/430,744 patent/US20150307596A1/en not_active Abandoned
- 2013-10-04 JP JP2015535827A patent/JP2015535215A/ja active Pending
- 2013-10-04 AU AU2013326897A patent/AU2013326897A1/en not_active Abandoned
- 2013-10-04 CN CN201380061514.1A patent/CN105208876A/zh active Pending
- 2013-10-04 IN IN3203DEN2015 patent/IN2015DN03203A/en unknown
-
2015
- 2015-04-02 IL IL238111A patent/IL238111A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013326897A1 (en) | 2015-05-07 |
| MX2015004258A (es) | 2015-09-25 |
| CA2886996A1 (en) | 2014-04-10 |
| EP2903450A1 (en) | 2015-08-12 |
| IL238111A0 (en) | 2015-05-31 |
| CN105208876A (zh) | 2015-12-30 |
| US20150307596A1 (en) | 2015-10-29 |
| EP2903450A4 (en) | 2016-05-11 |
| WO2014055893A1 (en) | 2014-04-10 |
| RU2015116883A (ru) | 2016-11-27 |
| HK1213148A1 (zh) | 2016-06-30 |
| JP2015535215A (ja) | 2015-12-10 |
| SG11201502430QA (en) | 2015-04-29 |
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