IN2014MN02582A - - Google Patents

Info

Publication number
IN2014MN02582A
IN2014MN02582A IN2582MUN2014A IN2014MN02582A IN 2014MN02582 A IN2014MN02582 A IN 2014MN02582A IN 2582MUN2014 A IN2582MUN2014 A IN 2582MUN2014A IN 2014MN02582 A IN2014MN02582 A IN 2014MN02582A
Authority
IN
India
Prior art keywords
compound
formula
present
discloses
preparing
Prior art date
Application number
Inventor
Dharmaraj Ramachandra Rao
Rajendra Narayanrao Kankan
Srinivas Laxminarayan Pathi
Ravikumar Puppala
Manish Gangrade
Shashirekha Kanathala
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Priority to IN2582MUN2014 priority Critical patent/IN2014MN02582A/en
Publication of IN2014MN02582A publication Critical patent/IN2014MN02582A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention discloses a compound having the formula (II): The present invention also discloses a method of preparing a compound of formula (II) comprising condensing a compound of formula (I) with (S,S)-2,8-Diazabicyclo [4.3.0] nonane in an organic solvent to obtain the compound of formula (II). The present invention further discloses a method of preparing moxifloxacin base comprising: hydrolysing a compound of formula (H) to get moxifloxacin base.
IN2582MUN2014 2006-11-13 2007-11-13 IN2014MN02582A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IN2582MUN2014 IN2014MN02582A (en) 2006-11-13 2007-11-13

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1879MU2006 2006-11-13
PCT/GB2007/004320 WO2008059223A2 (en) 2006-11-13 2007-11-13 Process for the synthesis of moxifloxacin hydrochloride
IN2582MUN2014 IN2014MN02582A (en) 2006-11-13 2007-11-13

Publications (1)

Publication Number Publication Date
IN2014MN02582A true IN2014MN02582A (en) 2015-09-11

Family

ID=38947366

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2582MUN2014 IN2014MN02582A (en) 2006-11-13 2007-11-13

Country Status (10)

Country Link
US (1) US8198451B2 (en)
EP (2) EP2089388B1 (en)
JP (2) JP2010509305A (en)
KR (2) KR20150048920A (en)
AU (1) AU2007320997B2 (en)
CA (1) CA2669427A1 (en)
IN (1) IN2014MN02582A (en)
NZ (1) NZ576929A (en)
WO (1) WO2008059223A2 (en)
ZA (1) ZA200903889B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150048920A (en) 2006-11-13 2015-05-07 씨아이피엘에이 엘티디. Process for the synthesis of moxifloxacin hydrochloride
CN101817820B (en) * 2009-07-30 2011-10-05 重庆博腾制药科技股份有限公司 Method for synthesizing moxifloxacin hydrochloride
WO2011121596A2 (en) * 2010-04-01 2011-10-06 Neuland Laboratories Ltd. Crystal modification of moxifloxacin hydrochloride
CN102309458B (en) * 2010-07-09 2016-02-03 北京圣医耀科技发展有限责任公司 Sodium alginate cross-linking Moxifloxacin sustained-release micro-spheres, Preparation Method And The Use and the blood-vessels target suppository containing described microsphere
CN102617622B (en) * 2011-01-31 2016-06-15 深圳信立泰药业股份有限公司 A kind of prepare Moxifloxacin or the method for its pharmacologically acceptable salt and intermediate thereof
CN102276603B (en) * 2011-07-14 2012-10-24 福建省福抗药业股份有限公司 Clean preparation method of moxifloxacin hydrochloride
ITTO20110705A1 (en) 2011-07-29 2013-01-30 Italiana Sint Spa PROCEDURE FOR THE PREPARATION OF MOXIFLOXACINE CHLORIDRATE AND RELATED INTERMEDIATES
CN102659761B (en) * 2012-04-27 2017-10-10 常州市亚邦医药研究所有限公司 The preparation method of besifloxacin hydrochloride
FR2992218B1 (en) 2012-06-22 2015-01-23 Rivopharm Sa PHARMACEUTICAL COMPOSITION OF MOXIFLOXACIN HYDROCHLORIDE AND PROCESS FOR PREPARING THE SAME
CA2893534A1 (en) 2012-12-04 2014-06-12 Mankind Research Centre An improved process for the preparation of moxifloxacin hydrochloride
CN103102341A (en) * 2012-12-14 2013-05-15 浙江普洛康裕制药有限公司 Preparation method of balofloxacin dihydrate
CN103012452B (en) * 2012-12-25 2015-12-02 浙江新和成股份有限公司 The preparation method of a kind of Moxifloxacin and hydrochloride thereof
CN104098561B (en) * 2013-04-10 2016-01-20 山东省生物医药科学院 A kind of method preparing high-optical-purity Moxifloxacin hydrochloride of applicable suitability for industrialized production
CN104031043B (en) * 2014-05-28 2016-03-16 成都克莱蒙医药科技有限公司 A kind of Moxifloxacin hydrochloride synthetic method
CN104860944A (en) * 2015-06-09 2015-08-26 内蒙古东北六药集团有限公司 Production method of moxifloxacin hydrochloride
CN105237535A (en) * 2015-11-15 2016-01-13 青岛麦瑞特医药技术有限公司 Method for preparing moxifloxacin hydrochloride
CN105669671A (en) * 2016-03-10 2016-06-15 陈红 Preparation method of moxifloxacin hydrochloride
CN110143959B (en) * 2019-05-10 2022-04-26 广西两面针亿康药业股份有限公司 Preparation method of moxifloxacin hydrochloride

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YU46451B (en) * 1987-04-08 1993-10-20 Chinoin Gyogyszer Es Vegyeszeti Ter Mekek Gyara Rt. PROCESS FOR PREPARATION OF MIXED ANHYDRIDS OF QUINOLINE-CARBOXYL AND BORIC ACID
DE3906365A1 (en) 1988-07-15 1990-01-18 Bayer Ag 7- (1-PYRROLIDINYL) -3-CHINOLONE AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES, METHOD AND SUBSTITUTED (OXA) DIAZABICYCLOOCTANES AND NONANESE AS INTERMEDIATE PRODUCTS, AND ANTIBACTERIAL AGENTS AND FOOD ADDITIVES CONTAINING THEM
JPH0778065B2 (en) * 1990-07-06 1995-08-23 杏林製薬株式会社 (6,7-Substituted-8-alkoxy-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid-O ▲ above 3 ▼, O ▲ above 4) bis (acyloxy-O) Boron compound, salt thereof, and method for producing the same
TW209865B (en) 1992-01-10 1993-07-21 Bayer Ag
ES2077490B1 (en) * 1992-11-18 1996-10-16 Marga Investigacion TRIMETILSILILIC ESTERS AND SOLVATES OF CHELATES OF QUINOLIN-3-CARBOXYL ACIDS. PREPARATION AND APPLICATION TO THE QUINOLON PROCESS.
DE4342186A1 (en) 1993-12-10 1995-06-14 Bayer Ag One-pot process for the production of 3-quinolonecarboxylic acid derivatives
DE19546249A1 (en) * 1995-12-12 1997-06-19 Bayer Ag New crystal modification of 1-cyclopropyl-7 - ([S, S] -2,8-diazabicyclo [4,3,0] non-8-yl) -6-fluoro-1,4-dihydro-8-methoxy-4 -oxo-3-quinoline carboxylic acid hydrochloride (CDCH), process for its preparation and pharmaceutical preparations containing it
DE19821039A1 (en) * 1998-05-11 1999-11-18 Bayer Ag Production of (S,S)-8-benzyl-2,8-diazabicyclo(4.3.0)nonane useful as intermediate for antibiotic moxifloxacin
US6174878B1 (en) * 1999-08-31 2001-01-16 Alcon Laboratories, Inc. Topical use of kappa opioid agonists to treat otic pain
CN1184221C (en) * 2001-08-08 2005-01-12 中国医学科学院医药生物技术研究所 New quinaldinic acid derivative with 7-(7-aminomethyl-5-azaspiro [2,4] heplane) substituent and its preparation method
DE602004022646D1 (en) * 2003-04-09 2009-10-01 Reddys Lab Ltd Dr CRYSTALLINE FORM III OF A WATER-FREE MOXIFLOXACINE HYDROCHLORIDE AND A METHOD FOR THE PRODUCTION THEREOF
US20060264635A1 (en) 2003-08-05 2006-11-23 Chava Satyanarayana Process for the preparation of moxifloxacin hydrochloride
WO2005054240A1 (en) * 2003-11-20 2005-06-16 Chemi Spa Polymorphs of 1-cyclopropyl-7-([s,s]-2,8-diazadicyclo[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride and methods for the preparation thereof
US7320006B2 (en) * 2004-11-12 2008-01-15 Computer Sciences Corporation Hierarchical database management
WO2006134491A2 (en) * 2005-06-14 2006-12-21 Aurobindo Pharma Limited New crystalline form of moxifloxacin hydrochloride and process for its preparation
WO2007010555A2 (en) * 2005-07-15 2007-01-25 Msn Laboratories Limited Novel crystalline forms of moxifloxacin hydrochloride and process for preparation thereof
ES2284380B1 (en) 2006-03-10 2008-11-01 Quimica Sintetica S.A. PROCEDURE FOR THE PREPARATION OF MOXIFLOXACINO AND MOXIFLOXACINO CHLORHYDRATE.
KR20150048920A (en) 2006-11-13 2015-05-07 씨아이피엘에이 엘티디. Process for the synthesis of moxifloxacin hydrochloride

Also Published As

Publication number Publication date
EP2474547A2 (en) 2012-07-11
KR101539561B1 (en) 2015-07-27
EP2474547A3 (en) 2012-07-25
JP2014122223A (en) 2014-07-03
KR20150048920A (en) 2015-05-07
JP5774732B2 (en) 2015-09-09
EP2089388B1 (en) 2014-01-29
AU2007320997A1 (en) 2008-05-22
US8198451B2 (en) 2012-06-12
ZA200903889B (en) 2010-03-31
WO2008059223A2 (en) 2008-05-22
EP2089388A2 (en) 2009-08-19
US20100152229A1 (en) 2010-06-17
WO2008059223A3 (en) 2008-07-31
JP2010509305A (en) 2010-03-25
KR20090090337A (en) 2009-08-25
NZ576929A (en) 2012-07-27
AU2007320997B2 (en) 2012-11-08
CA2669427A1 (en) 2008-05-22

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