IN2014MN02367A - - Google Patents
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- Publication number
- IN2014MN02367A IN2014MN02367A IN2367MUN2014A IN2014MN02367A IN 2014MN02367 A IN2014MN02367 A IN 2014MN02367A IN 2367MUN2014 A IN2367MUN2014 A IN 2367MUN2014A IN 2014MN02367 A IN2014MN02367 A IN 2014MN02367A
- Authority
- IN
- India
- Prior art keywords
- blys
- stimulating factor
- blys antibody
- lymphocyte stimulating
- biopharmaceutics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention relates to the field of biopharmaceutics. Disclosed is an anti BLyS antibody. The anti BLyS antibody specifically targets BLyS can combine with a B lymphocyte stimulating factor and can inhibit the combination of the B lymphocyte stimulating factor with the receptor BR3 FC thereof. Also provided are uses of the anti BLyS antibody in the preparation of drugs for preventing and/or treating diseases such as systemic lupus erythematosus caused by the excessive proliferation of B cells.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210160474.3A CN103421113B (en) | 2012-05-22 | 2012-05-22 | Anti- BLyS antibody |
PCT/CN2013/076074 WO2013174264A1 (en) | 2012-05-22 | 2013-05-22 | Anti-blys antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014MN02367A true IN2014MN02367A (en) | 2015-08-14 |
Family
ID=49623127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN2367MUN2014 IN2014MN02367A (en) | 2012-05-22 | 2013-05-22 |
Country Status (8)
Country | Link |
---|---|
US (1) | US9828423B2 (en) |
EP (2) | EP3792280A3 (en) |
JP (1) | JP6006404B2 (en) |
CN (1) | CN103421113B (en) |
IN (1) | IN2014MN02367A (en) |
RU (1) | RU2613422C2 (en) |
WO (1) | WO2013174264A1 (en) |
ZA (1) | ZA201408955B (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3838923B1 (en) | 2012-08-24 | 2024-05-01 | The Regents of The University of California | Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis |
CN104045713B (en) * | 2013-03-13 | 2019-02-12 | 江苏诺迈博生物医药科技有限公司 | The monoclonal antibody of anti-Blys a kind of and pharmaceutical composition containing the antibody |
CN104804091B (en) * | 2014-01-29 | 2018-03-27 | 普瑞金(深圳)生物技术有限公司 | Nano antibody for resisting B cell growth stimulating factor and application |
CN104804092B (en) * | 2014-01-29 | 2018-03-27 | 天津胜发生物技术有限公司 | A kind of nano antibody of anti-B cell growth-stimulating factor and application thereof |
CN104804090B (en) * | 2014-01-29 | 2018-03-27 | 普瑞金(深圳)生物技术有限公司 | Nano antibody for resisting B cell growth stimulating factor and application |
EP3151857A4 (en) * | 2014-06-03 | 2018-04-18 | Merck Sharp & Dohme Corp. | Anti-blys antibodies |
CN104628856A (en) * | 2015-01-23 | 2015-05-20 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Anti-BLyS single-chain antibody as well as preparation method and use thereof |
CN105061596B (en) * | 2015-08-05 | 2019-01-29 | 江苏诺迈博生物医药科技有限公司 | The monoclonal antibody and its application of human B lymphocyte stimulating factor |
CN106916224B (en) * | 2015-12-28 | 2021-03-23 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | Monoclonal antibody for resisting B lymphocyte stimulating factor and its prepn and use |
SG11201811559WA (en) | 2016-06-27 | 2019-01-30 | Univ California | Cancer treatment combinations |
WO2018006824A1 (en) * | 2016-07-06 | 2018-01-11 | 上海开拓者生物医药有限公司 | Blys antibody, preparation method therefor and application thereof |
US11623953B2 (en) * | 2017-02-27 | 2023-04-11 | Caerus Therapeutics, Inc. | Antibody constructs and methods of treating cancer |
EP3918326A4 (en) * | 2019-01-31 | 2022-04-20 | Siemens Healthcare Diagnostics, Inc. | Anti-naloxone and anti-naltrexone monoclonal antibodies and methods of production and use thereof |
CN112111461B (en) * | 2020-08-17 | 2022-08-30 | 浙江正熙生物医药有限公司 | Method for constructing monoclonal antibody high-yield strain cell working library by single cell sorting |
WO2022223028A1 (en) * | 2021-04-23 | 2022-10-27 | 上海君实生物医药科技股份有限公司 | Anti-blys antibody, pharmaceutical composition thereof and use thereof |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6812327B1 (en) * | 1996-10-25 | 2004-11-02 | Human Genome Sciences, Inc. | Neutrokine-alpha polypeptides |
PT939804E (en) * | 1996-10-25 | 2005-11-30 | Human Genome Sciences Inc | ALPHA NEUTROQUIN |
KR101287395B1 (en) * | 2000-06-16 | 2014-11-04 | 휴먼 게놈 사이언시즈, 인코포레이티드 | Antibodies that immunospecifically bind to BLyS |
US7879328B2 (en) | 2000-06-16 | 2011-02-01 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator |
WO2003055979A2 (en) | 2001-11-16 | 2003-07-10 | Human Genome Sciences, Inc. | ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO BLyS |
US20020150579A1 (en) * | 2002-01-10 | 2002-10-17 | Kimberly Robert P. | B lymphocyte stimulator (BLyS) as a marker in management of systemic lupus erythematosus |
CN1168831C (en) * | 2002-05-24 | 2004-09-29 | 张志方 | Construction of recombinant human B lymphocyte stimulating factor expression vector, DNA immunopreparation of monoclonal antibody and use thereof |
RU2005141541A (en) * | 2003-06-05 | 2006-06-27 | Дженентек, Инк. (Us) | COMBINED THERAPY OF B-CELL DISORDERS |
KR20070001880A (en) * | 2003-10-20 | 2007-01-04 | 바이오겐 아이덱 엠에이 인코포레이티드 | Therapeutic regimens for baff antagonists |
CN101851291B (en) * | 2010-02-09 | 2011-10-26 | 中国人民解放军第四军医大学 | Heavy chain and light chain variable regions of anti-human BAFF monoclonal antibody |
-
2012
- 2012-05-22 CN CN201210160474.3A patent/CN103421113B/en active Active
-
2013
- 2013-05-22 IN IN2367MUN2014 patent/IN2014MN02367A/en unknown
- 2013-05-22 EP EP20180342.6A patent/EP3792280A3/en active Pending
- 2013-05-22 RU RU2014133410A patent/RU2613422C2/en active
- 2013-05-22 US US14/401,288 patent/US9828423B2/en active Active
- 2013-05-22 WO PCT/CN2013/076074 patent/WO2013174264A1/en active Application Filing
- 2013-05-22 JP JP2015511926A patent/JP6006404B2/en active Active
- 2013-05-22 EP EP13794561.4A patent/EP2853543B1/en active Active
-
2014
- 2014-12-05 ZA ZA2014/08955A patent/ZA201408955B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20150259409A1 (en) | 2015-09-17 |
CN103421113B (en) | 2018-01-19 |
ZA201408955B (en) | 2015-12-23 |
BR112014025651A2 (en) | 2017-07-04 |
EP2853543B1 (en) | 2020-09-02 |
RU2613422C2 (en) | 2017-03-16 |
EP2853543A4 (en) | 2016-03-30 |
EP2853543A8 (en) | 2015-05-13 |
EP2853543A1 (en) | 2015-04-01 |
JP6006404B2 (en) | 2016-10-12 |
RU2014133410A (en) | 2016-07-10 |
JP2015517505A (en) | 2015-06-22 |
WO2013174264A1 (en) | 2013-11-28 |
US9828423B2 (en) | 2017-11-28 |
EP3792280A3 (en) | 2021-07-21 |
EP3792280A2 (en) | 2021-03-17 |
CN103421113A (en) | 2013-12-04 |
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