IN2014KN01168A - - Google Patents

Info

Publication number
IN2014KN01168A
IN2014KN01168A IN1168KON2014A IN2014KN01168A IN 2014KN01168 A IN2014KN01168 A IN 2014KN01168A IN 1168KON2014 A IN1168KON2014 A IN 1168KON2014A IN 2014KN01168 A IN2014KN01168 A IN 2014KN01168A
Authority
IN
India
Prior art keywords
aptamer
analyte
sam
metal surface
complex
Prior art date
Application number
Other languages
English (en)
Inventor
Jonathan Michael Blackburn
Michael Evans
Sriram Krishnan
Christa Lynn Brosseau
Original Assignee
Univ Cape Town
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cape Town filed Critical Univ Cape Town
Publication of IN2014KN01168A publication Critical patent/IN2014KN01168A/en

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553Metal or metal coated
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56905Protozoa
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/5695Mycobacteria
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/35Nature of the modification
    • C12N2310/351Conjugate
    • C12N2310/3517Marker; Tag
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/10Applications; Uses in screening processes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2610/00Assays involving self-assembled monolayers [SAMs]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IN1168KON2014 2011-11-02 2012-11-02 IN2014KN01168A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA201108016 2011-11-02
PCT/IB2012/056108 WO2013065016A1 (en) 2011-11-02 2012-11-02 A method of detecting and/or quantifying an analyte in a biological sample

Publications (1)

Publication Number Publication Date
IN2014KN01168A true IN2014KN01168A (ko) 2015-10-16

Family

ID=47222168

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1168KON2014 IN2014KN01168A (ko) 2011-11-02 2012-11-02

Country Status (8)

Country Link
US (1) US9518986B2 (ko)
EP (1) EP2773958B1 (ko)
CN (1) CN104380105B (ko)
BR (1) BR112014010696A2 (ko)
DK (1) DK2773958T3 (ko)
IN (1) IN2014KN01168A (ko)
WO (1) WO2013065016A1 (ko)
ZA (1) ZA201403386B (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10422792B2 (en) * 2014-03-19 2019-09-24 The Regents Of The University Of Colorado Binding detection using liquid crystal
CA2976963A1 (en) * 2015-02-19 2016-08-25 Ionica Sciences Reagents and methods for detecting infectious diseases
CN105510411B (zh) * 2015-09-14 2018-05-08 陕西师范大学 基于细胞与微电极的相互作用实现单一癌细胞的检测方法
DE102015220414A1 (de) * 2015-10-20 2017-04-20 Robert Bosch Gmbh Propofolsensor zur Messung einer Narkosetiefe
CN105277527A (zh) * 2015-10-29 2016-01-27 江南大学 一种基于拉曼信标分子编码银@金核壳纳米粒子的真菌毒素双重检测方法
KR101816521B1 (ko) * 2016-01-28 2018-01-09 광주과학기술원 삽입제를 이용한 국소표면플라즈몬공명 기반 고감도 압타머 센서
US10103357B2 (en) 2016-02-17 2018-10-16 The Curators Of The University Of Missouri Fabrication of multilayer nanograting structures
EP3516557A4 (en) * 2016-10-28 2020-05-27 Hewlett-Packard Development Company, L.P. MODEL CHARACTERISTICS OF A TARGET CATEGORY
KR101923196B1 (ko) * 2017-09-25 2018-11-28 주식회사 엠디엡투스 Cfp10에 특이적으로 결합하는 dna 압타머 및 이의 용도
US20210190774A1 (en) * 2017-12-18 2021-06-24 The University Of Memphis Research Foundation Compositions and methods for the detection and molecular profiling of membrane bound vesicles
TWI686599B (zh) * 2018-05-24 2020-03-01 國立清華大學 塵蟎抗原檢測系統及方法
WO2020100159A1 (en) * 2018-11-13 2020-05-22 Translational Health Science And Technology Institute A novel aptamer and an electrochemical biosensor for the rapid detection and diagnosis of tuberculous meningitis
WO2020132074A1 (en) 2018-12-18 2020-06-25 The University Of Memphis Research Foundation Compositions and methods for the detection and molecular profiling of membrane bound vesicles
TWI693403B (zh) * 2019-01-17 2020-05-11 逢甲大學 免疫檢測方法
CN114008446A (zh) * 2019-04-09 2022-02-01 新加坡科技研究局 采用表面增强拉曼光谱的分枝杆菌无标签检测
CN110907643A (zh) * 2019-12-02 2020-03-24 中国科学院重庆绿色智能技术研究院 一种大肠杆菌检测芯片的制备方法及检测芯片
TWI759776B (zh) * 2020-06-22 2022-04-01 淡江大學 檢測基板、拉曼光譜檢測系統及拉曼光譜檢測方法
CA3193691A1 (en) 2020-09-24 2022-03-31 Roya Khosravi-Far Systems, apparatus, and methods for detecting pathogens
CN112240881A (zh) * 2020-09-30 2021-01-19 合肥国研汉因检测科技有限公司 使用拉曼光谱法快速检测痕量芬太尼的方法
CN112986212B (zh) * 2021-03-10 2023-01-17 中国人民解放军海军军医大学 一种g-四链体核酸适配体与小分子相互作用的研究方法
CN115711873B (zh) * 2022-11-09 2024-05-28 清华大学 一种利用sers文件卡片进行定量分析的方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376556A (en) 1989-10-27 1994-12-27 Abbott Laboratories Surface-enhanced Raman spectroscopy immunoassay
ES2259800T3 (es) 1990-06-11 2006-10-16 Gilead Sciences, Inc. Procedimientos de uso de ligandos de acido nucleico.
EP0598003B1 (en) 1991-07-22 1999-02-10 Kloehn Instruments, Ltd. Substrate for surface-enhanced analytical procedures, and substrates prepared for specific procedures
JP2965502B2 (ja) 1996-02-20 1999-10-18 株式会社京都第一科学 表面増強ラマン散乱測定による分析方法
GB9810865D0 (en) 1998-05-20 1998-07-22 Zeneca Ltd Nucleic acid sequence identification
JP4647792B2 (ja) 1999-04-28 2011-03-09 イジュノシッヒ テクニッヒ ホッフシューラ チューリッヒ 分析用デバイスおよびセンシングデバイスにおけるポリイオン性コーティング
EP1226422B1 (en) 1999-10-06 2007-11-28 Oxonica Inc. Surface enhanced spectroscopy-active composite nanoparticles
DE10050632A1 (de) 2000-10-12 2002-04-18 Stiftung Caesar Verfahren zum Nachweis biologischer Moleküle
US7238477B2 (en) 2001-09-24 2007-07-03 Intel Corporation Methods to increase nucleotide signals by Raman scattering
US7807348B2 (en) 2002-03-20 2010-10-05 Wisconsin Alumni Research Foundation Optical imaging of nanostructured substrates
US7361313B2 (en) 2003-02-18 2008-04-22 Intel Corporation Methods for uniform metal impregnation into a nanoporous material
US7192703B2 (en) 2003-02-14 2007-03-20 Intel Corporation, Inc. Biomolecule analysis by rolling circle amplification and SERS detection
US20050148100A1 (en) * 2003-12-30 2005-07-07 Intel Corporation Methods and devices for using Raman-active probe constructs to assay biological samples
US7351591B2 (en) 2004-03-30 2008-04-01 Intel Corporation Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
WO2006073439A2 (en) 2004-04-23 2006-07-13 Oxonica, Inc. Surface enhanced spectroscpy-active composite nanop articles and their application in analysis and diagnosis
WO2006076040A2 (en) 2004-06-07 2006-07-20 Weimer, Wayne, A. Systems and method for fabricating substrate surfaces for sers and apparatuses utilizing same
CN101057132B (zh) 2004-11-04 2012-04-18 雷尼绍诊断有限公司 用于增强的拉曼光谱学的金属纳米孔光子晶体
US7485471B1 (en) 2004-12-17 2009-02-03 Intel Corporation Detection of enhanced multiplex signals by surface enhanced Raman spectroscopy
US7355704B2 (en) 2005-06-13 2008-04-08 Solaris Nanosciences, Inc. Chemical and biological sensing using metallic particles in amplifying and absorbing media
US20070134815A1 (en) 2005-07-11 2007-06-14 Danielle Chamberlin Sensitivity enhancement of POCT devices using gold and silver nanoparticles on substrates containing nanostructures or nanoparticles that interact with labeling particles
US7651863B2 (en) 2005-07-14 2010-01-26 3M Innovative Properties Company Surface-enhanced spectroscopic method, flexible structured substrate, and method of making the same
US20090298197A1 (en) 2005-11-15 2009-12-03 Oxonica Materials Inc. Sers-based methods for detection of bioagents
GB0524580D0 (en) * 2005-12-01 2006-01-11 Sphere Medical Ltd Sensor
GB0606088D0 (en) 2006-03-27 2006-05-03 E2V Biosensors Ltd Improved serrs substrate
CA2681523C (en) 2007-03-20 2017-11-28 Kristin Weidemaier Assays using surface-enhanced raman spectroscopy (sers)-active particles
WO2009020479A2 (en) 2007-04-27 2009-02-12 The Regents Of The University Of California Device and methods for detection of airborne agents
KR100892629B1 (ko) 2007-06-29 2009-04-08 한국과학기술원 표면 증강 라만 분광용 광 센서
JP2009031023A (ja) 2007-07-25 2009-02-12 Keio Gijuku 表面増強ラマン分光分析用基板の作成方法、マイクロtasの製造方法、及び、マイクロtas
US20100055803A1 (en) 2008-08-29 2010-03-04 Kwangyeol Lee Method and apparatus for detecting molecules
US8947657B2 (en) * 2008-09-08 2015-02-03 Lawrence Livermore National Security, Llc Methods for isolation and viability assessment of biological organisms
US20100105053A1 (en) * 2008-10-10 2010-04-29 Hansang Cho Aptamer based sensors and related methods and systems
AU2010328768B2 (en) * 2009-12-11 2014-01-16 Korea Research Institute Of Chemical Technology A dimeric core-shell nanostructure labeled with a raman active molecule localized at an interparticle junction, use thereof, and method for preparing the same
TWI487910B (zh) * 2010-09-07 2015-06-11 國立成功大學 倒多角錐陣列型免標定病毒檢測基板、系統及方法

Also Published As

Publication number Publication date
EP2773958B1 (en) 2017-11-29
CN104380105A (zh) 2015-02-25
DK2773958T3 (en) 2018-03-12
US20140302492A1 (en) 2014-10-09
BR112014010696A2 (pt) 2017-04-25
EP2773958A1 (en) 2014-09-10
CN104380105B (zh) 2017-04-12
ZA201403386B (en) 2016-02-24
US9518986B2 (en) 2016-12-13
WO2013065016A1 (en) 2013-05-10

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