IN2014DN11215A - - Google Patents

Info

Publication number
IN2014DN11215A
IN2014DN11215A IN11215DEN2014A IN2014DN11215A IN 2014DN11215 A IN2014DN11215 A IN 2014DN11215A IN 11215DEN2014 A IN11215DEN2014 A IN 11215DEN2014A IN 2014DN11215 A IN2014DN11215 A IN 2014DN11215A
Authority
IN
India
Prior art keywords
seeds
proteins
nucleic acid
fatty acids
acid sequences
Prior art date
Application number
Other languages
English (en)
Inventor
Peter Denolf
Michel Van Thournout
Stephane Bourot
Original Assignee
Bayer Cropscience Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Nv filed Critical Bayer Cropscience Nv
Publication of IN2014DN11215A publication Critical patent/IN2014DN11215A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • A01H5/10—Seeds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/20—Brassicaceae, e.g. canola, broccoli or rucola
    • A01H6/201—Brassica juncea
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/003—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1288—Transferases for other substituted phosphate groups (2.7.8)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/08—Transferases for other substituted phosphate groups (2.7.8)
    • C12Y207/08002—Diacylglycerol cholinephosphotransferase (2.7.8.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
IN11215DEN2014 2012-07-06 2013-07-04 IN2014DN11215A (enExample)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12175303 2012-07-06
US201261669370P 2012-07-09 2012-07-09
PCT/EP2013/064186 WO2014006158A1 (en) 2012-07-06 2013-07-04 Brassica rod1 gene sequences and uses thereof

Publications (1)

Publication Number Publication Date
IN2014DN11215A true IN2014DN11215A (enExample) 2015-10-02

Family

ID=49881388

Family Applications (1)

Application Number Title Priority Date Filing Date
IN11215DEN2014 IN2014DN11215A (enExample) 2012-07-06 2013-07-04

Country Status (6)

Country Link
US (3) US9873886B2 (enExample)
EP (1) EP2870248A1 (enExample)
AU (2) AU2013285456B2 (enExample)
CA (2) CA2878286C (enExample)
IN (1) IN2014DN11215A (enExample)
WO (1) WO2014006158A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9873886B2 (en) * 2012-07-06 2018-01-23 Bayer Cropscience Nv Brassica ROD1 gene sequences and uses thereof
WO2018140782A1 (en) 2017-01-27 2018-08-02 Marks Michael David Plants having increased oil quality
US11337391B2 (en) 2017-08-18 2022-05-24 Regents Of The University Of Minnesota Early flowering plants
US11707029B2 (en) 2017-08-18 2023-07-25 Regents Of The University Of Minnesota Oilseed plants having reduced pod shatter
US12221612B2 (en) 2018-02-12 2025-02-11 Regents Of The University Of Minnesota Plants having increased oil quality
EP3802521A1 (de) 2018-06-04 2021-04-14 Bayer Aktiengesellschaft Herbizid wirksame bizyklische benzoylpyrazole
EP3847262A1 (en) 2018-09-07 2021-07-14 Basf Plant Science Company GmbH Improved method for the production of high levels of pufa in plants
CA3110664A1 (en) * 2018-09-07 2020-03-12 Basf Plant Science Company Gmbh Improved method for the production of high levels of pufa in plants
US11408008B2 (en) 2019-03-28 2022-08-09 Regents Of The University Of Minnesota Plants having increased oil quality
US20220389439A1 (en) * 2019-11-12 2022-12-08 Universidad De Salamanca TRANSGENIC PLANTS FROM THE BRASSICA spp. GENUS WITH MYCORRHIZATION CAPACITY AND HAVING AN INCREASED PRODUCTIVITY
CN117210432A (zh) * 2022-11-24 2023-12-12 东北农业大学 大豆磷脂酰胆碱甘油二脂胆碱磷酸转移酶在调控种子油酸中的应用
CN118910147A (zh) * 2024-09-20 2024-11-08 山东农业大学 调控抗病性的TaROD1基因及其在小麦育种中的应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2811889A (en) 1987-10-20 1989-05-23 Plant Genetic Systems N.V. A process for the production of biologically active peptide via the expression of modified storage seed protein genes in transgenic plants
GB8810120D0 (en) 1988-04-28 1988-06-02 Plant Genetic Systems Nv Transgenic nuclear male sterile plants
EP0573443B1 (en) 1991-02-08 2006-07-05 Bayer BioScience N.V. Stamen-specific promoters from rice
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
CA2119557C (en) 1991-09-24 2004-02-24 Marc Zabeau Selective restriction fragment amplification: a general method for dna fingerprinting
US6211431B1 (en) 1994-08-30 2001-04-03 Commonwealth Scientific And Industrial Research Organization Plant transcription regulators from circovirus
HUP9802535A3 (en) 1995-10-06 2001-04-28 Plant Genetic Systems Nv Seed shattering
US5985557A (en) 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US5977436A (en) 1997-04-09 1999-11-02 Rhone Poulenc Agrochimie Oleosin 5' regulatory region for the modification of plant seed lipid composition
EP2267138B1 (en) 1998-04-08 2016-06-08 Commonwealth Scientific and Industrial Research Organization Methods and means for obtaining modified phenotypes
US6405019B1 (en) 1998-06-30 2002-06-11 Ericsson, Inc. Method and apparatus for controlling a performance characteristic of an electronic device
US7495148B2 (en) 2000-07-14 2009-02-24 Unicrop Ltd Double recoverable block of function
CA2430642A1 (en) 2000-12-01 2003-02-20 John B. Ohlrogge Plant seed specific promoters
AU2002224668B2 (en) 2001-01-26 2007-09-20 Commonwealth Scientific And Industrial Research Organisation Methods and means for producing efficient silencing construct using recombinational cloning
BR0308424A (pt) 2002-03-14 2005-02-22 Commw Scient Ind Res Org Métodos e meios para infra-regular eficientemente a expressão de qualquer gene de interesse em células e organismos eucarióticos
DE10211617A1 (de) 2002-03-15 2003-09-25 Inst Pflanzengenetik & Kultur Neuer Promotor mit erhöhtem Expressionsprofil
US8304610B2 (en) * 2002-05-15 2012-11-06 Viterra, Inc. Brassica juncea lines with high oleic acid profile in seed oil
US7423198B2 (en) * 2002-05-15 2008-09-09 Viterra, Inc. High oleic acid Brassica juncea
AU2006203892B2 (en) 2005-01-07 2011-03-24 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Method to trigger RNA interference
CN101155921B (zh) 2005-04-04 2013-02-06 拜尔作物科学公司 用于去除所选择dna序列的方法和手段
US20100223691A1 (en) 2007-06-22 2010-09-02 Keygene N.V. Targeted nucleotide exchange with improved modified oligonucleotides
SI2167667T1 (sl) 2007-07-09 2016-03-31 Bayer Cropscience Nv Rastlina Brassica, ki vsebuje mutirane alele maščobne acil-ACP tioesteraze
WO2009064784A1 (en) * 2007-11-13 2009-05-22 Pioneer Hi-Bred International, Inc. Brassica juncea lines with a canola fatty acid profile
EP2227548B1 (en) 2007-12-04 2014-10-08 Dow Global Technologies LLC Seed-preferred gene promoters from the castor plant
DE112008003237T5 (de) 2007-12-14 2011-03-17 Basf Plant Science Gmbh Promotoren von Brassica napus für samenspezifische Genexpression
CA2717747A1 (en) * 2008-03-04 2009-09-11 Washington State University Compositions and methods for differential regulation of fatty acid unsaturation in membrane lipids and seed oil
JP5158639B2 (ja) 2008-04-11 2013-03-06 独立行政法人農業生物資源研究所 植物の内胚乳に特異的に発現する遺伝子および該遺伝子のプロモーター、並びにそれらの利用
AU2010321249B2 (en) * 2009-11-20 2015-04-09 BASF Agricultural Solutions Seed US LLC Brassica plants comprising mutant FAD3 alleles
US9873886B2 (en) * 2012-07-06 2018-01-23 Bayer Cropscience Nv Brassica ROD1 gene sequences and uses thereof

Also Published As

Publication number Publication date
AU2013285456A1 (en) 2015-01-22
US20180195080A1 (en) 2018-07-12
CA3195951A1 (en) 2014-01-09
AU2018256637A1 (en) 2018-11-22
US20220204983A1 (en) 2022-06-30
WO2014006158A1 (en) 2014-01-09
CA2878286C (en) 2023-06-13
AU2018256637B2 (en) 2021-05-13
CA2878286A1 (en) 2014-01-09
US9873886B2 (en) 2018-01-23
AU2013285456B2 (en) 2018-08-02
US20150143573A1 (en) 2015-05-21
EP2870248A1 (en) 2015-05-13

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