IN2014DN09313A - - Google Patents

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Publication number
IN2014DN09313A
IN2014DN09313A IN9313DEN2014A IN2014DN09313A IN 2014DN09313 A IN2014DN09313 A IN 2014DN09313A IN 9313DEN2014 A IN9313DEN2014 A IN 9313DEN2014A IN 2014DN09313 A IN2014DN09313 A IN 2014DN09313A
Authority
IN
India
Prior art keywords
starch
excipient
fluidized bed
paste
orally disintegrating
Prior art date
Application number
Inventor
Masao Umezaki
Hiroshige Murase
Toshio Uno
Toshiyuki Niwa
Original Assignee
Japan Corn Starch Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Corn Starch Co Ltd filed Critical Japan Corn Starch Co Ltd
Publication of IN2014DN09313A publication Critical patent/IN2014DN09313A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
    • C08B30/06—Drying; Forming
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
    • C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
    • C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
    • C08B30/14—Cold water dispersible or pregelatinised starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/02—Starch; Degradation products thereof, e.g. dextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2303/00—Characterised by the use of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08J2303/02—Starch; Degradation products thereof, e.g. dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

A method for producing starch granules suitable as an excipient for an orally disintegrating tablet. A paste is sprayed in small amounts while ß starch is being fluidized using an air fluidized bed to carry out fluidized bed granulation. Thereafter fluidized bed drying is carried out at the gelatinization temperature of the ß starch or higher. This results in starch granules having a high degree of gelatinization in comparison with the amount of gelatinized starch adhered to the ß starch by the spraying of the paste. These starch granules alone impart an adequate oral disintegration performance and breaking strength to the tablet. Consequently in instances of use as an excipient for tableting of orally disintegrating tablets another auxiliary excipient such as crystalline cellulose or a sugar or the like need not be added.
IN9313DEN2014 2012-04-27 2013-04-23 IN2014DN09313A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012103267 2012-04-27
PCT/JP2013/061900 WO2013161805A1 (en) 2012-04-27 2013-04-23 Method for producing starch granules, and orally disintegrating tablet

Publications (1)

Publication Number Publication Date
IN2014DN09313A true IN2014DN09313A (en) 2015-07-10

Family

ID=49483114

Family Applications (1)

Application Number Title Priority Date Filing Date
IN9313DEN2014 IN2014DN09313A (en) 2012-04-27 2013-04-23

Country Status (8)

Country Link
US (1) US9642807B2 (en)
EP (1) EP2842986B1 (en)
JP (1) JP5879668B2 (en)
KR (1) KR101879197B1 (en)
IL (1) IL235293A (en)
IN (1) IN2014DN09313A (en)
MY (1) MY169160A (en)
WO (1) WO2013161805A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6632960B2 (en) * 2016-12-07 2020-01-22 オルガノフードテック株式会社 Method for producing starch
JP7133970B2 (en) * 2018-04-27 2022-09-09 株式会社エクセディ Rotating electric machine
JP7782842B2 (en) * 2022-06-02 2025-12-09 株式会社パウレック Method for producing rapidly disintegrating compression molded product and rapidly disintegrating compression molded product
CN115532168B (en) * 2022-10-18 2024-06-25 江苏福瑞达新材料有限公司 Granulation equipment for chemical materials and use method thereof
CN115819806A (en) * 2022-12-27 2023-03-21 湖北三江丰源实业有限公司 Preparation method of cationic starch granules

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS535725B2 (en) 1973-03-05 1978-03-01
JPS5399340A (en) 1977-02-08 1978-08-30 Nisshin Flour Milling Co Production of starch granules
JPS5827774B2 (en) 1977-08-23 1983-06-11 武田薬品工業株式会社 Method for producing starch particles
JPS5827774A (en) 1981-08-12 1983-02-18 Sumitomo Chem Co Ltd Driving method of construction reducing frictional force between soil and driving pipe
FR2647050B1 (en) * 1989-05-16 1991-11-22 Seppic Sa PROCESS FOR THE MANUFACTURE OF A DIRECTLY COMPRESSIBLE STARCH FOR USE IN THE MANUFACTURE OF TABLETS AND TABLETS OBTAINED
US5725676A (en) 1993-07-30 1998-03-10 National Starch And Chemical Investment Holding Corporation Thermally inhibited starches and flours and process for their production
US6221420B1 (en) 1993-07-30 2001-04-24 National Starch And Chemical Investment Holding Corporation Foods containing thermally-inhibited starches and flours
US5932017A (en) 1993-07-30 1999-08-03 National Starch And Chemical Investment Holding Corporation Thermally-inhibited non-pregelatinized granular starches and flours and process for their preparation
US6451121B2 (en) 1993-07-30 2002-09-17 National Starch And Chemical Investment Holding Corporation Thermally-inhibited non-pregelatinized granular starches and flours and process for their preparation
US5720822A (en) 1995-06-07 1998-02-24 National Starch And Chemical Investment Holding Corporation Thermally-inhibited pregelatinized non-granular starches and flours and process for their production
JP3345652B2 (en) 1994-06-29 2002-11-18 明治製菓株式会社 Stabilized composition comprising colistin sulfate
CA2172962C (en) * 1994-07-29 1999-09-21 Chung-Wai Chiu Thermally inhibited starches and flours and process for their production
US5718770A (en) 1994-08-25 1998-02-17 National Starch And Chemical Investment Holding Corporation Thermally-inhibited pregelatinized granular starches and flours and process for their production
WO2007066646A1 (en) * 2005-12-06 2007-06-14 Asahi Kasei Chemicals Corporation Process for producing tablet by high-speed direct compression
JP2008032767A (en) 2006-07-26 2008-02-14 Matsushita Electric Ind Co Ltd Active noise reduction system
EP2062599A4 (en) * 2006-09-14 2013-03-27 Astellas Pharma Inc Orally disintegrating tablet and process for production thereof
US9187573B2 (en) 2007-07-26 2015-11-17 Cargill, Incorporated Process for modifying starches
US20100330369A1 (en) 2008-02-22 2010-12-30 Cargill Incorporated Pregelatinized starches as carrier materials for liquid components
EP2261263B1 (en) 2008-03-31 2022-03-23 Asahi Kasei Kabushiki Kaisha Processed starch powder with excellent disintegration properties and manufacturing method thereof
US20110288146A1 (en) * 2008-11-19 2011-11-24 Nandu Deorkar Directly compressible granular microcrystalline cellulose based, excipient, manufacturing process and use thereof
WO2011124656A1 (en) 2010-04-07 2011-10-13 Cargill, Incorporated Process for modifying starches

Also Published As

Publication number Publication date
JPWO2013161805A1 (en) 2015-12-24
EP2842986B1 (en) 2018-12-26
MY169160A (en) 2019-02-19
IL235293A (en) 2017-02-28
WO2013161805A1 (en) 2013-10-31
KR20150013562A (en) 2015-02-05
US9642807B2 (en) 2017-05-09
US20150141525A1 (en) 2015-05-21
EP2842986A1 (en) 2015-03-04
KR101879197B1 (en) 2018-08-17
JP5879668B2 (en) 2016-03-08
EP2842986A4 (en) 2015-09-09

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