IN2014DN08526A - - Google Patents

Info

Publication number
IN2014DN08526A
IN2014DN08526A IN8526DEN2014A IN2014DN08526A IN 2014DN08526 A IN2014DN08526 A IN 2014DN08526A IN 8526DEN2014 A IN8526DEN2014 A IN 8526DEN2014A IN 2014DN08526 A IN2014DN08526 A IN 2014DN08526A
Authority
IN
India
Application number
Other languages
English (en)
Inventor
Alex Xenopoulos
Original Assignee
Emd Millipore Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49783749&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN08526(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Emd Millipore Corp filed Critical Emd Millipore Corp
Publication of IN2014DN08526A publication Critical patent/IN2014DN08526A/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/49—Mixing systems, i.e. flow charts or diagrams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/21—Measuring
    • B01F35/2132—Concentration, pH, pOH, p(ION) or oxygen-demand
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/715—Feeding the components in several steps, e.g. successive steps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/10061—Methods of inactivation or attenuation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IN8526DEN2014 2012-06-29 2014-10-13 IN2014DN08526A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261666145P 2012-06-29 2012-06-29
PCT/US2013/045677 WO2014004103A1 (fr) 2012-06-29 2013-06-13 Méthodes permettant d'inactiver des virus lors d'un procédé de purification de protéines

Publications (1)

Publication Number Publication Date
IN2014DN08526A true IN2014DN08526A (fr) 2015-05-15

Family

ID=49783749

Family Applications (1)

Application Number Title Priority Date Filing Date
IN8526DEN2014 IN2014DN08526A (fr) 2012-06-29 2014-10-13

Country Status (8)

Country Link
US (1) US9809799B2 (fr)
EP (2) EP2867359B1 (fr)
JP (2) JP6182210B2 (fr)
CN (2) CN104411820B (fr)
ES (1) ES2895173T3 (fr)
IN (1) IN2014DN08526A (fr)
SG (1) SG11201406407TA (fr)
WO (1) WO2014004103A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2682168A1 (fr) 2012-07-02 2014-01-08 Millipore Corporation Dispositif de tirage et métier à filer
RU2662929C2 (ru) 2013-03-08 2018-07-31 Джензим Корпорейшн Интегрированное непрерывное производство терапевтических белковых лекарственных веществ
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
EP4234569A3 (fr) 2014-04-15 2023-10-18 Boehringer Ingelheim International GmbH Procédé et utilisation d'inactivation continue de virus pendant la fabrication de produit biologique
JP6521351B2 (ja) 2014-10-14 2019-05-29 テックプロジェクトサービス株式会社 ウィルス不活化およびサンプリング装置
EP3277397A1 (fr) * 2015-03-31 2018-02-07 GE Healthcare Bio-Sciences AB Système de chromatographie liquide et dispositif et procédé s'y rapportant
WO2016207328A1 (fr) * 2015-06-24 2016-12-29 Glycotope Gmbh Procédé pour la purification de polypeptides γ-carboxylés
JP7032046B2 (ja) * 2016-01-22 2022-03-08 旭化成メディカル株式会社 生理活性物質の連続的な定流速精製方法
SG11201807824UA (en) * 2016-03-11 2018-10-30 Boehringer Ingelheim Int Methods for continuously inactivating a virus during manufacture of a protein
CN105841984A (zh) * 2016-03-18 2016-08-10 中国石油天然气股份有限公司 聚合物配注工艺设备检测评价装置
WO2018039163A1 (fr) * 2016-08-23 2018-03-01 Alexion Pharmaceuticals, Inc. Procédé de purification d'une protéine hétérologue à partir d'un blanc d'œuf
CN110831682A (zh) * 2017-05-11 2020-02-21 Emd密理博公司 在连续流动体系中保持窄停留时间分布的方法
CN110891665B (zh) * 2017-05-11 2022-01-14 Emd密理博公司 在连续流动体系中保持窄停留时间分布的机械方法
JP6596043B2 (ja) 2017-07-31 2019-10-23 株式会社Ｓｕｂａｒｕ 車両の走行制御システム
GB201802593D0 (en) * 2018-02-16 2018-04-04 Fujifilm Diosynth Biotechnologies Uk Ltd Rig
EP3843869A1 (fr) 2018-08-31 2021-07-07 Genzyme Corporation Résine de chromatographie stérile et son utilisation dans des procédés de fabrication
SG11202103790WA (en) * 2018-11-15 2021-05-28 Bayer Healthcare Llc Viral inactivation methods for continuous manufacturing of antibodies
WO2020117760A1 (fr) * 2018-12-03 2020-06-11 Duke University Procédé de purification de nanoparticules et de protéines recombinantes
CN113302197A (zh) * 2019-01-23 2021-08-24 第一三共株式会社 包括使用活性炭材料的工序的纯化抗体的方法
KR20210009982A (ko) * 2019-07-18 2021-01-27 에이비온 주식회사 2당화된 인터페론-베타 단백질의 정제 방법
FR3099066B1 (fr) * 2019-07-26 2021-08-13 Novasep Process Procédé de purification d’une substance cible avec inactivation virale
WO2021197249A1 (fr) * 2020-03-30 2021-10-07 上海复宏汉霖生物技术股份有限公司 Système et procédé de purification continue de molécules cibles
AU2021293805A1 (en) 2020-06-16 2022-12-22 Boehringer Ingelheim International Gmbh A method of providing a homogeneous feed stream within a plug flow reactor
CA3230984A1 (fr) * 2021-10-07 2023-04-13 Ross BROWNE Systemes et methodes de modelisation et de regulation du ph
EP4357009A1 (fr) 2022-10-17 2024-04-24 Sartorius Stedim Biotech GmbH Procédé et appareil de fonctionnement d'un processus en aval continu

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
WO1993017724A1 (fr) * 1992-03-02 1993-09-16 Bioeng, Inc. Procede d'inactivation virale
KR960703167A (ko) 1993-06-23 1996-06-19 존 더블유. 아담슨 혈액내 바이러스 불활성화 시스템(system for viral inactivation of blood)
EP2290053A1 (fr) 1994-11-10 2011-03-02 Baxter Healthcare S.A. Procédé pour la production du virus de la grippe dans un milieu de culture céllulaire sans protéines
US6686191B1 (en) 1995-09-22 2004-02-03 Bayer Healthcare Llc Preparation of virally inactivated intravenously injectable immune serum globulin
GB9611698D0 (en) 1996-06-05 1996-08-07 Iatros Ltd Fluid processing
EP0973544B1 (fr) 1997-04-08 2001-06-27 Baxter Aktiengesellschaft Preparation immunotolerante contenant un complexe de prothrombine
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
DE19923027C2 (de) * 1999-05-19 2002-09-19 Aventis Behring Gmbh Verfahren zur Inaktivierung von Viren
WO2002092806A1 (fr) * 2001-05-15 2002-11-21 V.I. Technologies, Inc. Appareils permettant d'inactiver des pathogenes dans des fluides contenant des proteines
EP1415669A1 (fr) 2002-09-19 2004-05-06 Aventis Behring GmbH Procédé de stérilisation pour compositions biologiques comprenant des proteines
WO2004058046A2 (fr) 2002-12-20 2004-07-15 Baxter International Inc. Methode, appareil et systeme de traitement de fluides
US20040256329A1 (en) 2003-06-13 2004-12-23 Peter Meserol Photodynamic biological fluid pathogen inactivation/filtering apparatus and method
US8271139B2 (en) 2003-10-17 2012-09-18 Asahi Kasei Bioprocess, Inc. Multi-stage accurate blending system and method
WO2005090403A2 (fr) 2004-03-12 2005-09-29 Biovest International, Inc. Procede et appareil de purification de proteines
NZ562949A (en) 2005-04-11 2009-05-31 Medarex Inc Protein purification using HCIC and ion exchange chromatography
US20090149638A1 (en) 2007-10-03 2009-06-11 Ley Arthur C Systems and methods for purifying proteins
CN103396480A (zh) 2008-05-15 2013-11-20 诺沃—诺迪斯克有限公司 抗体纯化方法
TW201028433A (en) * 2008-10-20 2010-08-01 Abbott Lab Viral inactivation during purification of antibodies
WO2010141039A1 (fr) * 2008-10-20 2010-12-09 Abbott Laboratories Isolement et purification d'anticorps par chromatographie d'affinité de la protéine a
SG195555A1 (en) 2008-12-24 2013-12-30 Emd Millipore Corp Caustic stable chromatography ligands
WO2011028753A1 (fr) 2009-09-01 2011-03-10 Genentech, Inc. Purification améliorée d'une protéine grâce à une élution modifiée de la protéine a
US9527010B2 (en) 2009-09-25 2016-12-27 Ge Healthcare Bio-Sciences Corp. Separation system and method
CA2808116C (fr) * 2010-07-30 2016-06-07 Pfizer Inc. Purification en tandem de proteines
CN103379949B (zh) 2010-10-11 2016-09-14 艾伯维巴哈马有限公司 蛋白纯化方法
JP2013544524A (ja) * 2010-12-06 2013-12-19 ターポン バイオシステムズ，インコーポレイテッド 生物学的生成物の連続プロセス法
SG186552A1 (en) 2011-06-08 2013-01-30 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
EP2732021B1 (fr) * 2011-07-08 2020-05-27 EMD Millipore Corporation Filtres en profondeur jetables améliorés pour processus biotechnologiques
US9096648B2 (en) * 2011-08-19 2015-08-04 Emd Millipore Corporation Methods of reducing level of one or more impurities in a sample during protein purification
CN102492040B (zh) * 2011-12-29 2014-06-25 嘉和生物药业有限公司 一种抗her2或/和抗her3抗体蛋白的纯化方法
EP2682168A1 (fr) 2012-07-02 2014-01-08 Millipore Corporation Dispositif de tirage et métier à filer
RU2662929C2 (ru) 2013-03-08 2018-07-31 Джензим Корпорейшн Интегрированное непрерывное производство терапевтических белковых лекарственных веществ

Also Published As

Publication number Publication date
CN107188926A (zh) 2017-09-22
JP6457575B2 (ja) 2019-01-23
WO2014004103A1 (fr) 2014-01-03
CN104411820B (zh) 2017-05-03
EP2867359B1 (fr) 2021-09-15
ES2895173T3 (es) 2022-02-17
JP2017148051A (ja) 2017-08-31
SG11201406407TA (en) 2014-11-27
JP6182210B2 (ja) 2017-08-16
JP2015522017A (ja) 2015-08-03
US9809799B2 (en) 2017-11-07
CN104411820A (zh) 2015-03-11
EP2867359A1 (fr) 2015-05-06
CN107188926B (zh) 2021-02-09
EP3981873A1 (fr) 2022-04-13
EP2867359A4 (fr) 2015-11-11
US20150064769A1 (en) 2015-03-05

Similar Documents

Publication Publication Date Title
BR112014025798A2 (fr)
BR112014017635A2 (fr)
BR112014017614A2 (fr)
BR112014017592A2 (fr)
BR112014017625A2 (fr)
BR112014017659A2 (fr)
BR112014017646A2 (fr)
BR112014017638A2 (fr)
BR112014017607A2 (fr)
BR112013027865A2 (fr)
BR112014017634A2 (fr)
BR112014017609A2 (fr)
BR112014017644A2 (fr)
BR112014017647A2 (fr)
BR112014017588A2 (fr)
BR112014017618A2 (fr)
BR112014013184A8 (fr)
BR112014017630A2 (fr)
BR112014017652A2 (fr)
BR112014017621A2 (fr)
BR112014017627A2 (fr)
BR112014017623A2 (fr)
BR112014017622A2 (fr)
BR112014017641A2 (fr)
BR112014017631A2 (fr)