IN2014DN06772A - - Google Patents

Info

Publication number
IN2014DN06772A
IN2014DN06772A IN6772DEN2014A IN2014DN06772A IN 2014DN06772 A IN2014DN06772 A IN 2014DN06772A IN 6772DEN2014 A IN6772DEN2014 A IN 6772DEN2014A IN 2014DN06772 A IN2014DN06772 A IN 2014DN06772A
Authority
IN
India
Prior art keywords
hematocrit
marker
fluorescent
markers
subjects
Prior art date
Application number
Inventor
Daniel Meier
Bruce Molitoris
Erinn Sheridan
Ruben Sandoval
Original Assignee
Pharmacophotonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacophotonics Inc filed Critical Pharmacophotonics Inc
Publication of IN2014DN06772A publication Critical patent/IN2014DN06772A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14535—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring haematocrit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
    • A61B5/201—Assessing renal or kidney functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions

Abstract

Methods of measurement of biometric indicators in a mammalian subject are described. Biometric indicators of interest include hematocrit plasma volume volume of distribution and glomerular filtration rate. The methods are especially applicable to subjects with rapid blood loss and to subjects with unstable hematocrits. Hematocrit may be measured by administering an injectate with a dynamic fluorescent marker and a static fluorescent marker or a single static marker with two fluorescent tags into the vascular system of the subject and monitoring the emission intensities of the markers or fluorescent tags over a period of time. Hematocrit may then be calculated using a calibrated spectrometric analyzer by determining the raw ratio of the markers at T0 calculating the apparent hematocrit and applying a correction factor.
IN6772DEN2014 2012-02-17 2013-02-15 IN2014DN06772A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261600182P 2012-02-17 2012-02-17
PCT/US2013/026277 WO2013123285A1 (en) 2012-02-17 2013-02-15 Compositions and methods for monitoring biometric indicators

Publications (1)

Publication Number Publication Date
IN2014DN06772A true IN2014DN06772A (en) 2015-05-22

Family

ID=48984726

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6772DEN2014 IN2014DN06772A (en) 2012-02-17 2013-02-15

Country Status (8)

Country Link
US (2) US20140369936A1 (en)
EP (2) EP3207873A1 (en)
JP (3) JP2015510436A (en)
CN (2) CN104244826A (en)
AU (1) AU2013221451A1 (en)
CA (1) CA2863788A1 (en)
IN (1) IN2014DN06772A (en)
WO (1) WO2013123285A1 (en)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
WO2013123285A1 (en) * 2012-02-17 2013-08-22 Pharmacophotonics, Inc. Compositions and methods for monitoring biometric indicators
WO2015061680A1 (en) 2013-10-24 2015-04-30 Pharmacophotonics, Inc. D/B/A Fast Biomedical Compositions and methods for optimizing the detection of fluorescent signals from biomarkers
EP3313286B1 (en) * 2015-06-24 2021-09-15 Pharmacophotonics, Inc. D/B/A Fast Biomedical Substance for use in determining biometric indicators using multiple fluorescent markers
WO2019143676A1 (en) * 2018-01-16 2019-07-25 Mayo Foundation For Medical Education And Research System and method for rapid assessment of renal function
CA3102965A1 (en) 2018-06-08 2019-12-12 Perkinelmer Health Sciences, Inc. Calibration of multispectral analysis systems
EP4269987A3 (en) * 2018-06-28 2024-01-03 Becton Dickinson and Company Systems and methods for normalizing signals in blood culture measurement systems
JP2022504413A (en) * 2018-10-05 2022-01-13 ファーマコフォトニクス，インコーポレイティド，ディー／ビー／エー ファスト バイオメディカル Methods and devices for determining gap volume

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US20060178556A1 (en) * 2001-06-29 2006-08-10 Intuitive Surgical, Inc. Articulate and swapable endoscope for a surgical robot
JP4347692B2 (en) * 2001-09-12 2009-10-21 テルモ株式会社 Drug container and drug injection device using the same
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US7796243B2 (en) * 2004-06-09 2010-09-14 National Research Council Of Canada Detection and monitoring of changes in mineralized tissues or calcified deposits by optical coherence tomography and Raman spectroscopy
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JP5033789B2 (en) * 2005-04-19 2012-09-26 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション Method for kidney function analysis
US7386333B1 (en) * 2005-04-29 2008-06-10 Henryk Birecki Test subject monitoring device
GB0718291D0 (en) * 2007-09-19 2007-10-31 King S College London Imaging apparatus and method
WO2009061769A1 (en) * 2007-11-06 2009-05-14 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern Califorina Measurement of hematocrit and cardiac output from optical transmission and reflection changes
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JP2011521899A (en) * 2008-04-18 2011-07-28 ファーマコフォトニクス，インコーポレイティド Method and apparatus for analyzing renal function
US8591865B2 (en) * 2008-04-18 2013-11-26 Pharmacophotonics, Inc. Renal function analysis method and apparatus
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AU2010242959B2 (en) * 2009-04-30 2016-06-02 Pharmacophotonics, Inc. Measurement of body fluid volumes
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WO2013123285A1 (en) * 2012-02-17 2013-08-22 Pharmacophotonics, Inc. Compositions and methods for monitoring biometric indicators

Also Published As

Publication number Publication date
EP2814393A1 (en) 2014-12-24
JP2015510436A (en) 2015-04-09
US20180256755A9 (en) 2018-09-13
CN108261183A (en) 2018-07-10
JP2020163170A (en) 2020-10-08
US20180147302A1 (en) 2018-05-31
CA2863788A1 (en) 2013-08-22
EP3207873A1 (en) 2017-08-23
WO2013123285A1 (en) 2013-08-22
CN104244826A (en) 2014-12-24
EP2814393A4 (en) 2015-10-14
AU2013221451A1 (en) 2014-08-21
JP2018102959A (en) 2018-07-05
EP2814393B1 (en) 2017-04-05
US20140369936A1 (en) 2014-12-18

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