IN2014DN00137A - - Google Patents

Download PDF

Info

Publication number
IN2014DN00137A
IN2014DN00137A IN137DEN2014A IN2014DN00137A IN 2014DN00137 A IN2014DN00137 A IN 2014DN00137A IN 137DEN2014 A IN137DEN2014 A IN 137DEN2014A IN 2014DN00137 A IN2014DN00137 A IN 2014DN00137A
Authority
IN
India
Prior art keywords
useful
intermediates
preparation
present processes
processes
Prior art date
Application number
Other languages
English (en)
Inventor
Roland E Dolle
Bourdonnec Bertrand Le
Pierre Martin
Christian Steffen Moessner
Felix Herbert Spindler
Dirk Jost Spielvogel
Original Assignee
Adolor Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adolor Corp filed Critical Adolor Corp
Publication of IN2014DN00137A publication Critical patent/IN2014DN00137A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IN137DEN2014 2011-07-18 2012-07-17 IN2014DN00137A (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161508817P 2011-07-18 2011-07-18
PCT/US2012/047082 WO2013012871A1 (en) 2011-07-18 2012-07-17 Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto

Publications (1)

Publication Number Publication Date
IN2014DN00137A true IN2014DN00137A (cs) 2015-05-22

Family

ID=47558430

Family Applications (1)

Application Number Title Priority Date Filing Date
IN137DEN2014 IN2014DN00137A (cs) 2011-07-18 2012-07-17

Country Status (9)

Country Link
US (1) US20150045556A1 (cs)
EP (1) EP2734041A4 (cs)
CN (1) CN103917096A (cs)
AU (1) AU2012284127A1 (cs)
CA (1) CA2842183A1 (cs)
HK (1) HK1199794A1 (cs)
IL (1) IL230506A0 (cs)
IN (1) IN2014DN00137A (cs)
WO (1) WO2013012871A1 (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103804431A (zh) * 2014-02-25 2014-05-21 中国人民解放军第四军医大学 一种手性二茂铁双膦配体及其制备方法
EP3421455B1 (en) * 2017-06-29 2019-03-27 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib
CN111051280B (zh) 2017-08-02 2023-12-22 弗特克斯药品有限公司 制备吡咯烷化合物的方法
JP7245834B2 (ja) 2017-12-08 2023-03-24 バーテックス ファーマシューティカルズ インコーポレイテッド 嚢胞性線維症膜コンダクタンス制御因子のモジュレーターを作成するためのプロセス

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2058265T3 (es) * 1987-04-16 1994-11-01 Lilly Co Eli Piperidinas antagonistas de opiaceos.
US5536858A (en) * 1994-02-12 1996-07-16 Hoffmann-La Roche Inc. Tetrasulfonated diphosphine compounds and metal complexes thereof for asymmetric catalytic reactions
US5553858A (en) * 1995-06-28 1996-09-10 Mckoon; Carl T. Golf putter
US6057456A (en) * 1997-10-16 2000-05-02 Yale University Transition metal-catalyzed process for preparing alpha-arylated carbonyl-containing compounds
US6900228B1 (en) * 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
TWI254043B (en) * 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
US6794510B2 (en) * 2002-08-08 2004-09-21 Adolor Corporation Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
RU2512285C2 (ru) * 2008-12-18 2014-04-10 Ф. Хоффманн-Ля Рош Аг Способ синтеза производных амино-метилтетралина

Also Published As

Publication number Publication date
WO2013012871A1 (en) 2013-01-24
EP2734041A4 (en) 2015-03-25
CN103917096A (zh) 2014-07-09
EP2734041A1 (en) 2014-05-28
AU2012284127A1 (en) 2013-05-02
US20150045556A1 (en) 2015-02-12
HK1199794A1 (en) 2015-07-24
IL230506A0 (en) 2014-03-31
CA2842183A1 (en) 2013-01-24

Similar Documents

Publication Publication Date Title
EP2590649A4 (en) PROCESS FOR SYNTHESIS OF SUBSTITUTED MORPHINANES
MY175272A (en) Novel benzimidazole derivatives as ep4 antagonists
MX350211B (es) Proceso para la preparacion del etil-ester del acido n- (4-ciclohexil-3-trifluoro-metil-benciloxi) -acetimidico.
TN2012000506A1 (en) Process for the preparation of pleuromutilins
EP2755955A4 (en) METHOD FOR PRODUCING SUBSTITUTED 3'-HYDRAZIN BIPHENYL-3-CARBOXYLIC ACID COMPOUNDS
PH12014501195A1 (en) Novel 2h-indazoles as ep2, receptor antagonists
WO2012061754A3 (en) Compounds and methods for treating autoimmune diseases
EP2632879A4 (en) PROCESS FOR PRODUCING PURIFIED XYLENE ISOMERS
WO2012015999A3 (en) Process for the preparation of imatinib mesylate
WO2004014310A3 (en) Novel processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
IN2014DN00144A (cs)
MX2014014138A (es) Procedimiento nuevo para la preparacion de acido 2-ciclopentil-6-metoxi-isonicotinico.
IN2014DN00137A (cs)
WO2010004578A3 (en) Novel and improved processes for the preparation of paliperidone
IN2015MN00013A (cs)
MX2012002818A (es) Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable.
WO2011004387A3 (en) Process for the preparation of dexlansoprazole polymorphic forms
WO2014087208A3 (en) A process of preparing alcaftadine
MX2014004688A (es) Proceso de obtencion de acidos isoxazolil-metoxi-nicotinicos.
TN2014000329A1 (en) Method for preparing compound by novel michael addition reaction using water or various acids as additive
WO2011157670A3 (en) Process for the preparation of benzamide derivatives
WO2012052939A3 (en) Preparation of bicyclo[2.2.2]octan-2-one compounds
MX2013004425A (es) Preparacion diastereoselectiva de los compuestos de biciclo [2.2.2] octan-2-ona.
MX2010006056A (es) Proceso para preparar ranitidina clorhidrato forma 2.
MX2013002656A (es) Nuevo proceso.