IN2014CN04160A - - Google Patents
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- Publication number
- IN2014CN04160A IN2014CN04160A IN4160CHN2014A IN2014CN04160A IN 2014CN04160 A IN2014CN04160 A IN 2014CN04160A IN 4160CHN2014 A IN4160CHN2014 A IN 4160CHN2014A IN 2014CN04160 A IN2014CN04160 A IN 2014CN04160A
- Authority
- IN
- India
- Prior art keywords
- synthesizing
- methods
- relates generally
- noribogaine
- addictive alkaloid
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- RAUCDOKTMDOIPF-UHFFFAOYSA-N hydroxyibogamine Natural products CCC1CC(C2)CC3C1N2CCC1=C3NC2=CC=C(O)C=C12 RAUCDOKTMDOIPF-UHFFFAOYSA-N 0.000 abstract 1
- RAUCDOKTMDOIPF-RYRUWHOVSA-N noribogaine Chemical compound N1([C@@H]2[C@H]3C[C@H](C1)C[C@@H]2CC)CCC1=C3NC2=CC=C(O)C=C12 RAUCDOKTMDOIPF-RYRUWHOVSA-N 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568568P | 2011-12-08 | 2011-12-08 | |
| PCT/US2012/067629 WO2013085850A2 (en) | 2011-12-08 | 2012-12-03 | Stereoselective total synthesis of noribogaine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN04160A true IN2014CN04160A (cs) | 2015-07-17 |
Family
ID=48575047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN4160CHN2014 IN2014CN04160A (cs) | 2011-12-08 | 2012-12-03 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8937061B2 (cs) |
| EP (1) | EP2788355A4 (cs) |
| JP (1) | JP2015509076A (cs) |
| CN (1) | CN104364256A (cs) |
| CA (2) | CA2856551C (cs) |
| HK (1) | HK1204604A1 (cs) |
| IL (1) | IL232724A (cs) |
| IN (1) | IN2014CN04160A (cs) |
| WO (1) | WO2013085850A2 (cs) |
| ZA (1) | ZA201403995B (cs) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9394294B2 (en) | 2010-05-11 | 2016-07-19 | Demerx, Inc. | Methods and compositions for preparing and purifying noribogaine |
| US9586954B2 (en) | 2010-06-22 | 2017-03-07 | Demerx, Inc. | N-substituted noribogaine prodrugs |
| US8802832B2 (en) | 2010-06-22 | 2014-08-12 | Demerx, Inc. | Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier |
| EP2595632A1 (en) | 2010-07-23 | 2013-05-29 | DemeRx, Inc. | Noribogaine compositions |
| EP2481740B1 (en) | 2011-01-26 | 2015-11-04 | DemeRx, Inc. | Methods and compositions for preparing noribogaine from voacangine |
| US9617274B1 (en) | 2011-08-26 | 2017-04-11 | Demerx, Inc. | Synthetic noribogaine |
| CN104364256A (zh) | 2011-12-08 | 2015-02-18 | 德莫科斯公司 | 降伊波加因碱的立体选择性全合成 |
| EP2807167A4 (en) * | 2012-01-25 | 2016-01-20 | Demerx Inc | INDOIND AND BENZO FURANKED ISOCHINUCLIDEN DERIVATIVES AND METHOD FOR THE MANUFACTURE THEREOF |
| WO2013112673A1 (en) * | 2012-01-25 | 2013-08-01 | Demerx, Inc. | Synthetic voacangine |
| CA2896133A1 (en) | 2012-12-20 | 2014-06-26 | Demerx, Inc. | Substituted noribogaine |
| CA3256416A1 (en) | 2013-03-15 | 2025-06-21 | Demerx Inc | Method for noribogaine treatment of addiction in patients on methadone |
| US9345711B2 (en) | 2014-02-18 | 2016-05-24 | Demerx, Inc. | Methods for acute and long-term treatment of drug addiction |
| US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
| WO2015126434A1 (en) | 2014-02-18 | 2015-08-27 | Demerx, Inc. | Methods for acute and long-term treatment of drug addiction |
| US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
| WO2015195673A2 (en) | 2014-06-18 | 2015-12-23 | Demerx, Inc. | Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them |
| US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
| PT3223906T (pt) | 2014-11-26 | 2021-05-05 | Demerx Inc | Métodos e composições para potencializar a ação de analgésicos de opioides usando alcaloides de iboga |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| WO2020212952A1 (en) | 2019-04-17 | 2020-10-22 | Compass Pathfinder Limited | Treatment of depression and other various disorders with psilocybin |
| AU2023342060A1 (en) | 2022-09-14 | 2025-04-03 | Soneira Inc., P.B.C. | Compositions of iboga alkaloids and methods of treatment |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2813873A (en) * | 1957-11-19 | Derivatives of the ibogaine alkaloids | ||
| US3639408A (en) * | 1967-06-03 | 1972-02-01 | Shionogi & Co | Process for the preparation of isoquinuclidine derivatives |
| ES2264562T3 (es) | 1994-07-25 | 2007-01-01 | Nda International, Inc. | Uso de derivados de noribogaina para tratar la dependencia quimica en mamiferos. |
| US5616575A (en) * | 1995-12-04 | 1997-04-01 | Regents Of The University Of Minnesota | Bioactive tricyclic ibogaine analogs |
| IL134796A0 (en) * | 1997-09-04 | 2001-04-30 | Novoneuron Inc | Noribogaine in the treatment of pain and drug addiction |
| US7220737B1 (en) * | 1997-09-04 | 2007-05-22 | Novoneuron, Inc | Noribogaine in the treatment of pain and drug addiction |
| CN102225937B (zh) * | 2011-05-04 | 2012-07-25 | 中国科学院昆明植物研究所 | 抗肿瘤生物碱类化合物，其药物组合物及其制备方法和应用 |
| CN104364256A (zh) | 2011-12-08 | 2015-02-18 | 德莫科斯公司 | 降伊波加因碱的立体选择性全合成 |
-
2012
- 2012-12-03 CN CN201280058362.5A patent/CN104364256A/zh active Pending
- 2012-12-03 EP EP12855135.5A patent/EP2788355A4/en not_active Withdrawn
- 2012-12-03 WO PCT/US2012/067629 patent/WO2013085850A2/en not_active Ceased
- 2012-12-03 CA CA2856551A patent/CA2856551C/en active Active
- 2012-12-03 IN IN4160CHN2014 patent/IN2014CN04160A/en unknown
- 2012-12-03 HK HK15103583.0A patent/HK1204604A1/xx unknown
- 2012-12-03 JP JP2014545969A patent/JP2015509076A/ja active Pending
- 2012-12-03 CA CA3122767A patent/CA3122767C/en active Active
- 2012-12-07 US US13/708,834 patent/US8937061B2/en active Active
-
2014
- 2014-05-20 IL IL232724A patent/IL232724A/en not_active IP Right Cessation
- 2014-05-30 ZA ZA2014/03995A patent/ZA201403995B/en unknown
- 2014-09-15 US US14/486,804 patent/US9403837B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015509076A (ja) | 2015-03-26 |
| CA3122767A1 (en) | 2013-06-13 |
| CA2856551A1 (en) | 2013-06-13 |
| HK1204604A1 (en) | 2015-11-27 |
| IL232724A (en) | 2017-07-31 |
| US20150005492A1 (en) | 2015-01-01 |
| CA2856551C (en) | 2021-06-22 |
| EP2788355A4 (en) | 2015-10-21 |
| WO2013085850A2 (en) | 2013-06-13 |
| US9403837B2 (en) | 2016-08-02 |
| EP2788355A2 (en) | 2014-10-15 |
| ZA201403995B (en) | 2016-09-28 |
| US8937061B2 (en) | 2015-01-20 |
| WO2013085850A3 (en) | 2014-12-18 |
| IL232724A0 (en) | 2014-08-03 |
| CN104364256A (zh) | 2015-02-18 |
| CA3122767C (en) | 2023-03-28 |
| US20130165647A1 (en) | 2013-06-27 |
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