IN2013MU03379AIN3379MU2013AIN2013MU03379AIN 2013MU03379 AIN2013MU03379 AIN 2013MU03379AIN 3379MU2013 AIN3379MU2013 AIN 3379MU2013AIN 2013MU03379 AIN2013MU03379 AIN 2013MU03379A
Authority
IN
India
Prior art keywords
formula
reacting
compound
phosphordiamidates
sofosbuvir
Prior art date
Application number
Inventor
Shri Prakash Dhar Dwivedi
Jayprakash Ajitsingh Parihar
Piyush Rajendra Sharma
Original Assignee
Cadila Healthcare Ltd
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Publication date
Application filed by Cadila Healthcare LtdfiledCriticalCadila Healthcare Ltd
Priority to IN3379MU2013priorityCriticalpatent/IN2013MU03379A/en
Publication of IN2013MU03379ApublicationCriticalpatent/IN2013MU03379A/en
ABSTRACT NOVEL SYNTHESIS OF SOFOSBUVIR The present invention provides a process for the preparation of sofosbuvir of Formula (I-Sp), the process comprising: reacting phenyloxy-phosphodichloridate of Formula (VII) with compound of Formula (VI) to obtain compound of Formula (V); reacting compound of Formula (V) with the appropriate amino ester of Formula (IV) to produce phenyl phosphordiamidates of Formula (III); and reacting phenyl phosphordiamidates of Formula (III) with nucleoside of Formula (II) to obtain compound of Formula (I-Sp)