IN2013MU02527A - - Google Patents
Info
- Publication number
- IN2013MU02527A IN2013MU02527A IN2527MU2013A IN2013MU02527A IN 2013MU02527 A IN2013MU02527 A IN 2013MU02527A IN 2527MU2013 A IN2527MU2013 A IN 2527MU2013A IN 2013MU02527 A IN2013MU02527 A IN 2013MU02527A
- Authority
- IN
- India
- Prior art keywords
- nucleotide sequence
- insulin
- leader peptide
- sequence encoding
- terminal end
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 6
- 239000002773 nucleotide Substances 0.000 abstract 5
- 125000003729 nucleotide group Chemical group 0.000 abstract 5
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2527MU2013 IN2013MU02527A (enrdf_load_html_response) | 2013-07-31 | 2014-07-31 | |
| US14/908,854 US10000544B2 (en) | 2013-07-31 | 2014-07-31 | Process for production of insulin and insulin analogues |
| SG11201600684XA SG11201600684XA (en) | 2013-07-31 | 2014-07-31 | Process for production of insulin and insulin analogues |
| EP14789420.8A EP3027645A2 (en) | 2013-07-31 | 2014-07-31 | Process for production of insulin and insulin analogues |
| PCT/IN2014/000506 WO2015015518A2 (en) | 2013-07-31 | 2014-07-31 | Process for production of insulin and insulin analogues |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2527MU2013 IN2013MU02527A (enrdf_load_html_response) | 2013-07-31 | 2014-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2013MU02527A true IN2013MU02527A (enrdf_load_html_response) | 2015-06-26 |
Family
ID=51794935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2527MU2013 IN2013MU02527A (enrdf_load_html_response) | 2013-07-31 | 2014-07-31 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10000544B2 (enrdf_load_html_response) |
| EP (1) | EP3027645A2 (enrdf_load_html_response) |
| IN (1) | IN2013MU02527A (enrdf_load_html_response) |
| SG (1) | SG11201600684XA (enrdf_load_html_response) |
| WO (1) | WO2015015518A2 (enrdf_load_html_response) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115716876A (zh) * | 2022-07-04 | 2023-02-28 | 北京惠之衡生物科技有限公司 | 一种融合蛋白及其应用 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3027643A2 (en) | 2013-07-31 | 2016-06-08 | Biogenomics Limited | Expression vector for production of recombinant proteins in prokaryotic host cells |
| MX2020001058A (es) * | 2017-07-28 | 2020-08-06 | Univ Princeton | Marcadores de fusión para expresión de proteínas recombinantes. |
| WO2020026045A2 (en) * | 2018-06-18 | 2020-02-06 | Unichem Laboratories Ltd | Leader sequence for higher expression of recombinant proteins |
| CN112584853B (zh) * | 2018-09-12 | 2021-12-10 | 美药星（南京）制药有限公司 | 一种新型门冬胰岛素原的结构和制备门冬胰岛素的方法 |
| US10799564B1 (en) | 2019-05-06 | 2020-10-13 | Baxter International Inc. | Insulin premix formulation and product, methods of preparing same, and methods of using same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004085472A1 (en) * | 2003-03-27 | 2004-10-07 | Novo Nordisk A/S | Method for making human insulin precursors and human insulin |
-
2014
- 2014-07-31 IN IN2527MU2013 patent/IN2013MU02527A/en unknown
- 2014-07-31 US US14/908,854 patent/US10000544B2/en active Active
- 2014-07-31 WO PCT/IN2014/000506 patent/WO2015015518A2/en active Application Filing
- 2014-07-31 SG SG11201600684XA patent/SG11201600684XA/en unknown
- 2014-07-31 EP EP14789420.8A patent/EP3027645A2/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115716876A (zh) * | 2022-07-04 | 2023-02-28 | 北京惠之衡生物科技有限公司 | 一种融合蛋白及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US10000544B2 (en) | 2018-06-19 |
| EP3027645A2 (en) | 2016-06-08 |
| US20160168226A1 (en) | 2016-06-16 |
| SG11201600684XA (en) | 2016-02-26 |
| WO2015015518A3 (en) | 2015-04-16 |
| WO2015015518A2 (en) | 2015-02-05 |
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