IN2013DE03197A - - Google Patents

Info

Publication number
IN2013DE03197A
IN2013DE03197A IN3197DE2013A IN2013DE03197A IN 2013DE03197 A IN2013DE03197 A IN 2013DE03197A IN 3197DE2013 A IN3197DE2013 A IN 3197DE2013A IN 2013DE03197 A IN2013DE03197 A IN 2013DE03197A
Authority
IN
India
Prior art keywords
venlafaxine
synthesis
short
isomer
yield
Prior art date
Application number
Inventor
Prataprao Chavan Subhash
Pralhad Pawar Kailash
Original Assignee
Council Scient Ind Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council Scient Ind Res filed Critical Council Scient Ind Res
Priority to PCT/IN2014/000687 priority Critical patent/WO2015063791A1/en
Priority to IN3197DE2013 priority patent/IN2013DE03197A/en
Priority to US15/033,506 priority patent/US9527800B2/en
Publication of IN2013DE03197A publication Critical patent/IN2013DE03197A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
    • C07C67/42—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester by oxidation of secondary alcohols or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

There is a need for short, resolution free asymmetric process for synthesis of one isomer of venlafaxine, (-)-venlafaxine. The invention provides a novel, short process of synthesis of (-)-venlafaxine, with yield greater than 50% and ee> 99%. This process can be used for racemic synthesis of venlafaxine with overall yield 65%.
IN3197DE2013 2013-10-29 2014-10-29 IN2013DE03197A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/IN2014/000687 WO2015063791A1 (en) 2013-10-29 2014-10-29 Novel process for total synthesis of venlafaxine
IN3197DE2013 IN2013DE03197A (en) 2013-10-29 2014-10-29
US15/033,506 US9527800B2 (en) 2013-10-29 2014-10-29 Process for total synthesis of venlafaxine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3197DE2013 IN2013DE03197A (en) 2013-10-29 2014-10-29

Publications (1)

Publication Number Publication Date
IN2013DE03197A true IN2013DE03197A (en) 2015-05-01

Family

ID=52144797

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3197DE2013 IN2013DE03197A (en) 2013-10-29 2014-10-29

Country Status (3)

Country Link
US (1) US9527800B2 (en)
IN (1) IN2013DE03197A (en)
WO (1) WO2015063791A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015063791A1 (en) 2013-10-29 2015-05-07 Council Of Scientific And Industrial Research Novel process for total synthesis of venlafaxine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56324B1 (en) * 1982-12-13 1991-06-19 American Home Prod Phenethylamine derivatives and intermediates therefor
DE60136263D1 (en) 2001-04-10 2008-12-04 Alembic Ltd Intermediate for the preparation of 1-Ä2-dimethylamino-1- (4-methoxyphenyl) -ethyl-ω-cyclohexanol
JP2009518407A (en) 2005-12-05 2009-05-07 ワイス Method for the selective synthesis of substituted 1- (2-amino-1-phenyl-ethyl) -cyclohexanol enantiomers
WO2010046808A2 (en) 2008-10-21 2010-04-29 Alembic Limited A process for the preparation of venlafaxine hydrochloride
WO2015063791A1 (en) 2013-10-29 2015-05-07 Council Of Scientific And Industrial Research Novel process for total synthesis of venlafaxine

Also Published As

Publication number Publication date
WO2015063791A1 (en) 2015-05-07
US20160272573A1 (en) 2016-09-22
US9527800B2 (en) 2016-12-27

Similar Documents

Publication Publication Date Title
MX2018011139A (en) Acrylic acid, and methods of producing thereof.
CL2017002854A1 (en) S-ketamine salt (s), s-ketamine salt (r) salt and processes for the preparation of s-ketamin
MX2017015133A (en) Processes to produce brivaracetam.
MX2016007297A (en) Process for purifying 2,5-dichlorophenol.
MX369501B (en) Process for the preparation of 5-fluoro-1h-pyrazoles starting from hexafluoropropene.
IN2013MU00646A (en)
BR112016015218A2 (en) microorganism with improved l-threonine production capacity and method to produce l-threonine using this
MX2016015543A (en) Process for the preparation of 5-fluoro-1h-pyrazoles starting from hexafluoropropene.
IN2013MU03070A (en)
MX2015013589A (en) Process and intermediates for the preparation of pregabalin.
IN2013CH05455A (en)
BR112016014000A2 (en) SYNTHESIS OF PROGESTERONE ENANTIOMER AND INTERMEDIATES THEREOF
MX2016009073A (en) (s)-3'-methyl-abscisic acid and esters thereof.
IN2013DE03197A (en)
MX2015015746A (en) Process for preparation of arformoterol of salt thereof.
SA518392272B1 (en) Semifinished Product, Method of Production and Use Thereof
MX2018014918A (en) Tetrahydropyranyl lower alkyl esters and the production of same using a ketene compound.
PH12016502592A1 (en) 3'-substituted-abscisic acid derivatives
MX2015011881A (en) Process for the preparation of 3,7-dimethylnonan-1-ol.
TW201611832A (en) Icaritin compound and application thereof
BR112016028698A2 (en) piperidine-4-carbothioamide preparation
BR112015028751A2 (en) Process for the preparation of 3,5-bis (fluoralkyl) pyrazole derivatives from alpha, alpha-dihaloamines
ZA201806301B (en) Process for converting s-enantiomer to its racemic form
MY187078A (en) Process of production of 7,8-dihydro-c15-aldehyde
IN2013MU01501A (en)