TW201611832A - Icaritin compound and application thereof - Google Patents

Icaritin compound and application thereof

Info

Publication number
TW201611832A
TW201611832A TW104130599A TW104130599A TW201611832A TW 201611832 A TW201611832 A TW 201611832A TW 104130599 A TW104130599 A TW 104130599A TW 104130599 A TW104130599 A TW 104130599A TW 201611832 A TW201611832 A TW 201611832A
Authority
TW
Taiwan
Prior art keywords
icaritin
compound
application
provides
present
Prior art date
Application number
TW104130599A
Other languages
Chinese (zh)
Other versions
TWI632907B (en
Inventor
Kun Meng
Bo Zhang
Cheng Tang
xian-da Yuan
Original Assignee
Beijing Shenogen Pharma Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Shenogen Pharma Group Ltd filed Critical Beijing Shenogen Pharma Group Ltd
Publication of TW201611832A publication Critical patent/TW201611832A/en
Application granted granted Critical
Publication of TWI632907B publication Critical patent/TWI632907B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention provides an icaritin compound. The icaritin compound is an icaritin hydrate, preparable by simple and efficient crystallication with a crystallization yield up to 95%. Therefore, the present invention provides a broad perspective in the application of icaratin.
TW104130599A 2014-09-16 2015-09-16 Icaritin compound crystal form and application thereof TWI632907B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
??201410472018.1 2014-09-16
CN201410472018.1A CN104230870A (en) 2014-09-16 2014-09-16 Icaritin compound and application thereof
CN201510419782.7A CN104945364B (en) 2014-09-16 2015-07-16 A kind of A Kela determines the purposes of compound and the compound
??201510419782.7 2015-07-16

Publications (2)

Publication Number Publication Date
TW201611832A true TW201611832A (en) 2016-04-01
TWI632907B TWI632907B (en) 2018-08-21

Family

ID=52219873

Family Applications (1)

Application Number Title Priority Date Filing Date
TW104130599A TWI632907B (en) 2014-09-16 2015-09-16 Icaritin compound crystal form and application thereof

Country Status (2)

Country Link
CN (2) CN104230870A (en)
TW (1) TWI632907B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105476957B (en) * 2014-12-18 2021-04-20 北京珅奥基医药科技有限公司 Acoradine injection and preparation method and application thereof
CN110699263B (en) * 2019-10-29 2021-05-11 浙江工业大学 Aspergillus niger YH-6 and application thereof in improving content of icaritin in epimedium

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101302548B (en) * 2007-05-09 2011-04-13 北京珅奥基医药科技有限公司 Preparation of icaritin
CN101200743B (en) * 2007-12-17 2010-12-15 北京珅奥基医药科技有限公司 Method for preparing hydrated icaritin
CN102038673B (en) * 2009-10-20 2012-07-25 北京珅奥基医药科技有限公司 Application of hydroxyl benzopyrone compound for preparing medicament for treating leukemia
CN103936705B (en) * 2014-05-05 2015-10-21 北京盛诺基医药科技有限公司 The crystal formation of A Kelading compound, the medicine containing this crystal formation and purposes

Also Published As

Publication number Publication date
CN104945364B (en) 2017-03-08
CN104945364A (en) 2015-09-30
TWI632907B (en) 2018-08-21
CN104230870A (en) 2014-12-24

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