IN2013DE00680A

IN2013DE00680A -

Info

Publication number: IN2013DE00680A
Authority: IN; India
Prior art keywords: nanoformulation; developed; lcnps; hydrotrope; docetaxel
Prior art date: 2013-03-08

Application number

Other languages

English (en)

Inventor

Jain Sanyog

Bhankur Neha

Kumar Swarnakar Nitin

Thanki Kaushik

Original Assignee

Nat Inst Of Pharmaceutical Education And Res Niper

Priority date

2013-03-08

Filing date

2013-03-08

Publication date

2015-06-26

2013-03-08 Application filed by Nat Inst Of Pharmaceutical Education And Res Niper filed Critical Nat Inst Of Pharmaceutical Education And Res Niper

2013-03-08 Priority to IN680DE2013 priority Critical patent/IN2013DE00680A/en

2015-06-26 Publication of IN2013DE00680A publication Critical patent/IN2013DE00680A/en

Links

239000002246 antineoplastic agent Substances 0.000 abstract 2
OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 2
OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 abstract 1
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
230000002051 biphasic effect Effects 0.000 abstract 1
239000006184 cosolvent Substances 0.000 abstract 1
229960003668 docetaxel Drugs 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229960000304 folic acid Drugs 0.000 abstract 1
235000019152 folic acid Nutrition 0.000 abstract 1
239000011724 folic acid Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000003752 hydrotrope Substances 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000002105 nanoparticle Substances 0.000 abstract 1
QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 abstract 1