IN2012DN02337A - - Google Patents

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Publication number
IN2012DN02337A
IN2012DN02337A IN2337DEN2012A IN2012DN02337A IN 2012DN02337 A IN2012DN02337 A IN 2012DN02337A IN 2337DEN2012 A IN2337DEN2012 A IN 2337DEN2012A IN 2012DN02337 A IN2012DN02337 A IN 2012DN02337A
Authority
IN
India
Prior art keywords
images
contrast
combined
produce images
tissue sections
Prior art date
Application number
Inventor
Garsha Karl
Pestano Gary
Otter Michael
Dea Nagy Alexandra
B Nagle Ray
Miller Phillip
Froehlich Jan
Day William
Original Assignee
Ventana Med Syst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ventana Med Syst Inc filed Critical Ventana Med Syst Inc
Publication of IN2012DN02337A publication Critical patent/IN2012DN02337A/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Multiple modality contrast can be used to produce images that can be combined and rendered to produce images similar to those produced with wavelength absorbing stains viewed under transmitted white light illumination. Images obtained with other complementary contrast modalities can be presented using engineered color schemes based on classical contrast methods used to reveal the same anatomical structures and histochemistry, thereby providing relevance to medical training and experience. Dark-field contrast images derived from refractive index and fluorescent DAPI counterstain images are combined to produce images similar to those obtained with conventional H&E staining for pathology interpretation. Such multi-modal image data can be streamed for live navigation of histological samples, and can be combined with molecular localizations of genetic DNA probes (FISH), sites of mRNA expression (mRNA-ISH), and immunohistochemical (IHC) probes localized on the same tissue sections, used to evaluate and map tissue sections prepared for imaging mass spectrometry.
IN2337DEN2012 2009-10-12 2010-10-07 IN2012DN02337A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25080909P 2009-10-12 2009-10-12
US27893609P 2009-10-13 2009-10-13
PCT/US2010/051857 WO2011046807A2 (en) 2009-10-12 2010-10-07 Multi-modality contrast and brightfield context rendering for enhanced pathology determination and multi-analyte detection in tissue

Publications (1)

Publication Number Publication Date
IN2012DN02337A true IN2012DN02337A (en) 2015-08-21

Family

ID=43876802

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2337DEN2012 IN2012DN02337A (en) 2009-10-12 2010-10-07

Country Status (10)

Country Link
US (1) US9310302B2 (en)
EP (1) EP2488860A4 (en)
JP (1) JP5540102B2 (en)
KR (1) KR101388291B1 (en)
CN (1) CN102667473B (en)
AU (1) AU2010307140B2 (en)
CA (1) CA2774422C (en)
IL (1) IL218553B (en)
IN (1) IN2012DN02337A (en)
WO (1) WO2011046807A2 (en)

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Also Published As

Publication number Publication date
WO2011046807A3 (en) 2011-09-01
WO2011046807A2 (en) 2011-04-21
EP2488860A2 (en) 2012-08-22
AU2010307140A1 (en) 2012-04-05
CA2774422C (en) 2017-08-29
JP2013507612A (en) 2013-03-04
US20120200694A1 (en) 2012-08-09
KR20120066654A (en) 2012-06-22
CA2774422A1 (en) 2011-04-21
AU2010307140B2 (en) 2014-05-15
IL218553A0 (en) 2012-05-31
CN102667473A (en) 2012-09-12
CN102667473B (en) 2016-06-08
JP5540102B2 (en) 2014-07-02
EP2488860A4 (en) 2015-12-16
KR101388291B1 (en) 2014-04-22
US9310302B2 (en) 2016-04-12
IL218553B (en) 2018-01-31

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