IN2012DN00446A - - Google Patents
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- Publication number
- IN2012DN00446A IN2012DN00446A IN446DEN2012A IN2012DN00446A IN 2012DN00446 A IN2012DN00446 A IN 2012DN00446A IN 446DEN2012 A IN446DEN2012 A IN 446DEN2012A IN 2012DN00446 A IN2012DN00446 A IN 2012DN00446A
- Authority
- IN
- India
- Prior art keywords
- immunogens
- compositions
- tau
- medicine
- treatment
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present disclosure relates to immunogens and compositions comprising an antigenic tau peptide, preferably linked to an immunogenic carrier for use in the treatment of tau-related neurological disorders. The disclosure further relates to methods for production of these immunogens and compositions and their use in medicine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22986009P | 2009-07-30 | 2009-07-30 | |
| PCT/IB2010/053313 WO2011013034A1 (en) | 2009-07-30 | 2010-07-20 | Antigenic tau peptides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN00446A true IN2012DN00446A (en) | 2015-05-15 |
Family
ID=42941871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN446DEN2012 IN2012DN00446A (en) | 2009-07-30 | 2010-07-20 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20110177109A1 (en) |
| EP (1) | EP2459214A1 (en) |
| JP (1) | JP2013500326A (en) |
| KR (2) | KR20120049900A (en) |
| CN (1) | CN102596236B (en) |
| AR (1) | AR078085A1 (en) |
| AU (1) | AU2010277254B2 (en) |
| CA (1) | CA2768346A1 (en) |
| CO (1) | CO6612199A2 (en) |
| IN (1) | IN2012DN00446A (en) |
| MX (1) | MX2012001194A (en) |
| NZ (2) | NZ618391A (en) |
| PE (1) | PE20120817A1 (en) |
| RU (2) | RU2518291C2 (en) |
| SG (1) | SG177637A1 (en) |
| TW (2) | TWI461209B (en) |
| WO (1) | WO2011013034A1 (en) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG171829A1 (en) | 2008-12-09 | 2011-07-28 | Coley Pharm Group Inc | Immunostimulatory oligonucleotides |
| US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
| UA107571C2 (en) | 2009-04-03 | 2015-01-26 | PHARMACEUTICAL COMPOSITION | |
| CA3239368A1 (en) | 2009-06-10 | 2010-12-16 | New York University | Immunological targeting of pathological tau proteins |
| AU2013205313B2 (en) * | 2010-10-07 | 2016-05-19 | Ac Immune S.A. | Phosphospecific antibodies recognising tau |
| RU2603078C2 (en) * | 2010-10-07 | 2016-11-20 | Ац Иммуне С.А. | Pharmaceutical composition |
| US20120244174A1 (en) | 2011-01-31 | 2012-09-27 | Intellect Neurosciences Inc. | Treatment of tauopathies |
| MX339762B (en) | 2011-09-28 | 2016-05-27 | Univ Autonoma Del Estado De Morelos | Immunomodulator metallopeptides (immps) and compositions containing same. |
| AR092779A1 (en) | 2011-10-07 | 2015-05-06 | Ac Immune Sa | PHARMACEUTICAL COMPOSITION THAT INCLUDES ANTIBODIES THAT JOIN TAU PROTEIN CONFORMERS |
| US9657091B2 (en) | 2012-04-05 | 2017-05-23 | Ac Immune S.A. | Humanized tau antibody |
| KR102494798B1 (en) * | 2012-07-03 | 2023-02-06 | 워싱턴 유니버시티 | Antibodies to tau |
| HUE048780T2 (en) | 2012-08-16 | 2020-09-28 | Ipierian Inc | Methods for treating tauopathy |
| US8980270B2 (en) | 2013-01-18 | 2015-03-17 | Ipierian, Inc. | Methods of treating a tauopathy |
| US9598485B2 (en) | 2013-03-15 | 2017-03-21 | Ac Immune S.A. | Anti-tau antibodies and methods of use |
| US10195257B2 (en) * | 2013-07-28 | 2019-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations comprising quillaja desacylsaponins and beta amyloid peptides or tau protein to induce a Th2 immune response |
| US10400018B2 (en) | 2014-02-14 | 2019-09-03 | Ipierian, Inc. | Tau peptides, anti-tau antibodies, and methods of use thereof |
| TW202136296A (en) | 2014-06-27 | 2021-10-01 | 美商C2N醫療診斷有限責任公司 | Humanized anti-tau antibodies |
| EP3166688B1 (en) | 2014-07-08 | 2024-08-21 | New York University | Tau imaging ligands and their uses in the diagnosis and treatment of tauopathy |
| US20180050097A1 (en) * | 2015-03-25 | 2018-02-22 | Stc. Unm | Immunotherapy compositions and methods for treatment of tauopathy and transgenic mouse |
| MA42380A (en) | 2015-07-06 | 2018-05-16 | Ucb Biopharma Sprl | ANTIBODIES BONDING TO TAU |
| EP3334453A4 (en) | 2015-08-13 | 2019-02-06 | New York University | SPECIFIC ANTIBODY MOLECULES OF THE ASP421 EPITOPE TRUNCATED FROM THE TAU PROTEIN AND THEIR USES IN THE DIAGNOSIS AND TREATMENT OF TAUOPATHY |
| EP3519425B1 (en) | 2016-09-29 | 2024-02-28 | Indi Molecular, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same |
| GB201700487D0 (en) | 2017-01-11 | 2017-02-22 | Hermon-Taylor John | Diagnostic |
| EA202091012A1 (en) | 2017-10-25 | 2020-08-27 | Янссен Фармасьютикалз, Инк. | COMPOSITIONS OF PHOSPHORYLATED TAU PEPTIDES AND THEIR APPLICATION |
| SG11202003624SA (en) * | 2017-10-27 | 2020-05-28 | United Neuroscience | Tau peptide immunogen constructs |
| CN109870581B (en) * | 2017-12-04 | 2021-05-04 | 厦门万泰凯瑞生物技术有限公司 | A kind of kit and method for quantitative detection of HBsAg |
| CN108314737B (en) * | 2018-01-25 | 2021-03-16 | 中国科学院过程工程研究所 | Recombinant protein and preparation method and application thereof |
| CN110548135B (en) | 2018-05-31 | 2023-06-06 | 长春百克生物科技股份公司 | Phosphorylated polypeptide antigen vaccine and its preparation method and application |
| GB201811382D0 (en) | 2018-07-11 | 2018-08-29 | Taylor John Hermon | Vaccine |
| AU2019356804B2 (en) * | 2018-10-07 | 2025-05-29 | Promis Neurosciences, Inc. | Conformation-specific epitopes in alpha-synuclein, antibodies thereto and methods related thereof |
| JP7681316B2 (en) * | 2019-02-08 | 2025-05-22 | プロセナ バイオサイエンシーズ リミテッド | Antibodies that recognize tau |
| KR20210125048A (en) | 2019-02-08 | 2021-10-15 | 에이씨 이뮨 에스.에이. | Safe Administration of Phosphorylated Tau Peptide Vaccine |
| US20200291391A1 (en) * | 2019-03-12 | 2020-09-17 | Indi Molecular, Inc. | Cross-linked epitopes and methods of use thereof |
| US12201679B2 (en) | 2019-04-05 | 2025-01-21 | Institute For Systems Biology | Epitope-targeted peptide immunostimulants |
| US11155609B2 (en) | 2019-04-05 | 2021-10-26 | TauC3 Biologies Limited | Anti-TAUC3 antibodies and uses thereof |
| JP7617852B2 (en) | 2019-04-24 | 2025-01-20 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | Heterologous administration of tau vaccine |
| WO2020236969A1 (en) | 2019-05-20 | 2020-11-26 | Indi Molecular, Inc. | Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1) |
| KR20220034733A (en) * | 2019-05-27 | 2022-03-18 | 더 유니버시티 오브 브리티쉬 콜롬비아 | Conformation-specific epitopes of tau, antibodies thereto, and methods related thereto |
| GB2585252A (en) * | 2019-07-05 | 2021-01-06 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
| US12209142B2 (en) | 2020-05-29 | 2025-01-28 | Institute For Systems Biology | SARS-CoV-2 epitope-targeted peptide immunostimulants |
| JP2023536746A (en) * | 2020-08-07 | 2023-08-29 | プロシーナ バイオサイエンシーズ リミテッド | Tau vaccine for treatment of Alzheimer's disease |
| JP7687699B2 (en) * | 2020-09-08 | 2025-06-03 | 国立大学法人大阪大学 | Immunogenic compositions targeting phosphorylated tau protein |
| IL311337A (en) * | 2021-09-08 | 2024-05-01 | Joint Stock Company «Biocad» | Bispecific antibody comprising a heterodimer based on mhc proteins |
| KR20240082368A (en) * | 2021-09-29 | 2024-06-10 | 얀센 파마슈티칼즈, 인코포레이티드 | Methods for Safe Administration of Tau Phosphopeptide Conjugates |
| CN115894659B (en) * | 2022-10-19 | 2023-11-10 | 上海优宁维生物科技股份有限公司 | Microtubule-associated protein Tau antigen, and preparation method and application thereof |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| AU568067B2 (en) | 1981-10-23 | 1987-12-17 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and methods of making same |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| DE3525624A1 (en) | 1985-07-18 | 1987-01-22 | Celamerck Gmbh & Co Kg | INSECTICIDALLY EFFECTIVE AGENT FOR CONTROLLING TEXTILE Pests |
| US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| GB8815795D0 (en) | 1988-07-02 | 1988-08-10 | Bkl Extrusions Ltd | Glazing bead |
| NZ230747A (en) | 1988-09-30 | 1992-05-26 | Bror Morein | Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina |
| CA2017507C (en) | 1989-05-25 | 1996-11-12 | Gary Van Nest | Adjuvant formulation comprising a submicron oil droplet emulsion |
| NZ235315A (en) | 1989-09-19 | 1991-09-25 | Wellcome Found | Chimaeric hepadnavirus core antigen proteins and their construction |
| SE466259B (en) | 1990-05-31 | 1992-01-20 | Arne Forsgren | PROTEIN D - AN IGD BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE, AND THE USE OF THIS FOR ANALYSIS, VACCINES AND PURPOSE |
| WO1992011291A1 (en) | 1990-12-20 | 1992-07-09 | Smithkline Beecham Biologicals (S.A.) | Vaccines based on hepatitis b surface antigen |
| EP2009104A1 (en) * | 1991-12-06 | 2008-12-31 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Phosphorylation epitopes of Tau protein for the diagnosis and treatment of Alzheimer's disease |
| EP0544942A1 (en) * | 1991-12-06 | 1993-06-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Novel tools for the diagnosis and treatment of Alzheimer disease |
| US7408027B1 (en) * | 1991-12-06 | 2008-08-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften | Tools for the diagnosis and treatment of Alzheimer's disease |
| SG90042A1 (en) | 1992-06-25 | 2002-07-23 | Smithkline Beecham Biolog | Vaccine composition containing adjuvants |
| BR9405957A (en) | 1993-03-23 | 1995-12-12 | Smithkline Beecham Biolog | Vaccine compositions containing 3-0 monophosphoryl deacylated lipid A |
| DE4321946A1 (en) | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonic acid esters, process for their preparation and their use |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| US5658738A (en) | 1994-05-31 | 1997-08-19 | Becton Dickinson And Company | Bi-directional oligonucleotides that bind thrombin |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| CA2560114A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| WO1996030523A2 (en) | 1995-03-31 | 1996-10-03 | Hans Wolf | Antigen presentation system based on retrovirus-like particles |
| GB9513261D0 (en) | 1995-06-29 | 1995-09-06 | Smithkline Beecham Biolog | Vaccines |
| US20020086009A1 (en) * | 1996-03-13 | 2002-07-04 | Koichi Ishiguro | Anti-phosphorylated tau protein antibodies and methods for detecting alzheimer`s disease with the use of the same |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| EP0930893B1 (en) | 1996-10-11 | 2005-04-13 | The Regents of The University of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
| WO1998022120A1 (en) * | 1996-11-19 | 1998-05-28 | The Wistar Institute Of Anatomy & Biology | Diagnostic and therapeutic reagents for alzheimer's disease |
| AUPO517897A0 (en) | 1997-02-19 | 1997-04-11 | Csl Limited | Chelating immunostimulating complexes |
| EP1039935A4 (en) | 1997-02-28 | 2005-04-27 | Univ Iowa Res Found | USE OF NUCLEIC ACIDS CONTAINING NON-METHYLIC CpG DINUCLEOTIDES IN THE TREATMENT OF LIPOPOLYSACCHARIDE ASSOCIATED DISORDERS |
| EP1005368B1 (en) | 1997-03-10 | 2009-09-02 | Ottawa Hospital Research Institute | Use of nucleic acids containing unmethylated CpG dinucleotide in combination with alum as adjuvants |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| EP0986572B2 (en) | 1997-06-06 | 2007-06-13 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| GB9717953D0 (en) | 1997-08-22 | 1997-10-29 | Smithkline Beecham Biolog | Vaccine |
| JP4426091B2 (en) | 1997-09-05 | 2010-03-03 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Oil-in-water emulsion containing saponin |
| CA2320488C (en) | 1998-02-12 | 2007-03-06 | Immune Complex, Corporation | Strategically modified hepatitis b core proteins and their derivatives |
| US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
| JP2002511423A (en) | 1998-04-09 | 2002-04-16 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | vaccine |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| EP1126876B1 (en) | 1998-10-16 | 2007-03-21 | GlaxoSmithKline Biologicals S.A. | Adjuvant systems and vaccines |
| ATE314095T1 (en) | 1998-10-21 | 2006-01-15 | Us Health | VIRUS-LIKE PARTICLES FOR INDUCING AUTOANTIBODIES |
| DE69929470T2 (en) | 1998-11-05 | 2006-08-24 | Powderject Vaccines, Inc., Madison | GENE CONSTRUCTS FOR GENIMMUNIZATION |
| EP1135162B1 (en) | 1998-11-30 | 2008-10-29 | Cytos Biotechnology AG | Ordered molecular presentation of allergens, method of preparation and use |
| AUPP807399A0 (en) | 1999-01-08 | 1999-02-04 | Csl Limited | Improved immunogenic lhrh composition and methods relating thereto |
| US7776343B1 (en) | 1999-02-17 | 2010-08-17 | Csl Limited | Immunogenic complexes and methods relating thereto |
| PL203917B1 (en) | 1999-03-19 | 2009-11-30 | Glaxosmithkline Biolog Sa | Vaccine |
| DE60014076T2 (en) | 1999-04-19 | 2005-10-13 | Glaxosmithkline Biologicals S.A. | ADJUVANS COMPOSITION, CONTAINING SAPONINE AND AN IMMUNOSTIMULATORY OLIGONUCLEOTIDE |
| BR0014282A (en) | 1999-09-24 | 2002-05-21 | Smithkline Beecham Biolog | Vaccines |
| CN1399539A (en) | 1999-09-24 | 2003-02-26 | 史密丝克莱恩比彻姆生物有限公司 | Adjuvant comprising polyxyethylene alkyl ether or ester and at least one nonionic surfactant |
| AU784345B2 (en) | 2000-04-07 | 2006-03-16 | University Of Leeds Innovations Limited | Hepatitis B core antigen fusion proteins |
| AU2001252458A1 (en) | 2000-05-05 | 2001-11-20 | Martin Bachmann | Molecular antigen arrays and vaccines |
| JP2004500868A (en) | 2000-06-22 | 2004-01-15 | セルテック ファーマスーティカルズ リミテッド | Modification of hepatitis B core antigen |
| WO2002005690A1 (en) | 2000-07-15 | 2002-01-24 | Lighthouse Display International Limited | Shelf edge display fittings |
| AUPQ912000A0 (en) | 2000-07-31 | 2000-08-24 | Crown In The Right Of The Queensland Department Of Health, The | Improved virus like particles |
| US20030138769A1 (en) | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| US7320793B2 (en) | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| WO2003102165A2 (en) | 2002-02-21 | 2003-12-11 | Apovia, Inc. | IMMUNOGENIC HBc CHIMER PARTICLES STABILIZED WITH AN N-TERMINAL CYSTEINE |
| DE60234375D1 (en) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | PACKAGING IMMUNSTIMULATING CpG IN VIRUS LIKE PARTICLES: PREPARATION METHOD AND USE |
| WO2003024480A2 (en) | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| US20040176283A1 (en) | 2002-04-01 | 2004-09-09 | Robinson John A. | Methods and compositions for the design of synthetic vaccines |
| GB0209878D0 (en) | 2002-04-30 | 2002-06-05 | Glaxosmithkline Biolog Sa | Vaccine |
| CN102061288A (en) | 2002-07-17 | 2011-05-18 | 希托斯生物技术股份公司 | Molecular antigen arrays using a virus like particle derived from the AP205 coat protein |
| MXPA05000819A (en) * | 2002-07-19 | 2005-08-29 | Cytos Biotechnology Ag | Vaccine compositions containing amyloid beta1-6 antigen arrays. |
| EP1572234B1 (en) | 2002-12-10 | 2012-02-22 | Sanofi Pasteur Biologics Co. | STABILIZED IMMUNOGENIC HBc CHIMER PARTICLES |
| EA010060B1 (en) * | 2003-12-17 | 2008-06-30 | Вайет | Immunogenic peptide carrier conjugates and method of producing same |
| US20070129320A9 (en) | 2004-07-18 | 2007-06-07 | Coley Pharmaceutical Group, Ltd. | Methods and compositions for inducing innate immune responses |
| WO2007026190A2 (en) | 2004-07-18 | 2007-03-08 | Csl Limited | Immuno stimulating complex and oligonucleotide formulations for inducing enhanced interferon-gamma responses |
| WO2006040153A2 (en) * | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| US8012936B2 (en) * | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| ATE473758T1 (en) * | 2006-04-13 | 2010-07-15 | Bio Life Science Forschungs & Entwicklungsgesellschaft Mbh | HER-2/NEW MULTIPEPTIDE VACCINE |
| US20080166785A1 (en) | 2006-08-16 | 2008-07-10 | Monica Sala-Schaeffer | Polynucleotides allowing the expression and secretion of recombinant HBsAg virus-like particles containing a foreign peptide, their production and use |
| CA3239368A1 (en) * | 2009-06-10 | 2010-12-16 | New York University | Immunological targeting of pathological tau proteins |
| FR3058624B1 (en) | 2016-11-15 | 2018-12-07 | L'oreal | BRUSH FOR APPLYING A PRODUCT ON THE LASHES AND / OR THE EYE |
-
2010
- 2010-07-20 NZ NZ618391A patent/NZ618391A/en not_active IP Right Cessation
- 2010-07-20 JP JP2012522292A patent/JP2013500326A/en active Pending
- 2010-07-20 KR KR1020127005415A patent/KR20120049900A/en not_active Abandoned
- 2010-07-20 EP EP10739402A patent/EP2459214A1/en not_active Withdrawn
- 2010-07-20 MX MX2012001194A patent/MX2012001194A/en not_active Application Discontinuation
- 2010-07-20 RU RU2012102701/10A patent/RU2518291C2/en not_active IP Right Cessation
- 2010-07-20 PE PE2012000116A patent/PE20120817A1/en not_active Application Discontinuation
- 2010-07-20 KR KR1020137028550A patent/KR20130127547A/en not_active Ceased
- 2010-07-20 IN IN446DEN2012 patent/IN2012DN00446A/en unknown
- 2010-07-20 CA CA2768346A patent/CA2768346A1/en not_active Abandoned
- 2010-07-20 WO PCT/IB2010/053313 patent/WO2011013034A1/en active Application Filing
- 2010-07-20 SG SG2012002390A patent/SG177637A1/en unknown
- 2010-07-20 NZ NZ598356A patent/NZ598356A/en not_active IP Right Cessation
- 2010-07-20 CN CN201080040148.8A patent/CN102596236B/en not_active Expired - Fee Related
- 2010-07-20 AU AU2010277254A patent/AU2010277254B2/en not_active Ceased
- 2010-07-29 US US12/846,719 patent/US20110177109A1/en not_active Abandoned
- 2010-07-29 AR ARP100102753A patent/AR078085A1/en unknown
- 2010-07-29 TW TW099125165A patent/TWI461209B/en not_active IP Right Cessation
- 2010-07-29 TW TW103104138A patent/TW201436804A/en unknown
-
2012
- 2012-02-15 CO CO12026764A patent/CO6612199A2/en unknown
-
2014
- 2014-03-31 RU RU2014112002/10A patent/RU2014112002A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ598356A (en) | 2014-06-27 |
| AR078085A1 (en) | 2011-10-12 |
| CA2768346A1 (en) | 2011-02-03 |
| SG177637A1 (en) | 2012-03-29 |
| KR20130127547A (en) | 2013-11-22 |
| CO6612199A2 (en) | 2013-02-01 |
| PE20120817A1 (en) | 2012-07-07 |
| CN102596236A (en) | 2012-07-18 |
| US20110177109A1 (en) | 2011-07-21 |
| AU2010277254B2 (en) | 2015-05-07 |
| RU2518291C2 (en) | 2014-06-10 |
| WO2011013034A1 (en) | 2011-02-03 |
| KR20120049900A (en) | 2012-05-17 |
| WO2011013034A4 (en) | 2011-04-28 |
| TWI461209B (en) | 2014-11-21 |
| NZ618391A (en) | 2015-07-31 |
| CN102596236B (en) | 2015-06-24 |
| MX2012001194A (en) | 2012-03-07 |
| TW201436804A (en) | 2014-10-01 |
| TW201106968A (en) | 2011-03-01 |
| RU2012102701A (en) | 2013-09-10 |
| EP2459214A1 (en) | 2012-06-06 |
| AU2010277254A1 (en) | 2012-02-09 |
| JP2013500326A (en) | 2013-01-07 |
| RU2014112002A (en) | 2015-10-10 |
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