IN2012DN00042A - - Google Patents

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Publication number
IN2012DN00042A
IN2012DN00042A IN42DEN2012A IN2012DN00042A IN 2012DN00042 A IN2012DN00042 A IN 2012DN00042A IN 42DEN2012 A IN42DEN2012 A IN 42DEN2012A IN 2012DN00042 A IN2012DN00042 A IN 2012DN00042A
Authority
IN
India
Prior art keywords
multidrug resistant
antibiotic
bacterium
resistant bacterium
provides
Prior art date
Application number
Inventor
Edvar Onsoyen
Rolf Myrvold
Arne Dessen
David Thomas
Timothy Walsh
Original Assignee
Algipharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0909557A external-priority patent/GB0909557D0/en
Priority claimed from GB0913829A external-priority patent/GB0913829D0/en
Priority claimed from GB0917995A external-priority patent/GB0917995D0/en
Application filed by Algipharma As filed Critical Algipharma As
Publication of IN2012DN00042A publication Critical patent/IN2012DN00042A/en

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Classifications

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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/734—Alginic acid
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    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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Abstract

The invention provides a method of overcoming resistance to at least one antibiotic in a multidrug resistant bacterium, said method comprising contacting said bacterium with an alginate oligomer together with the antibiotic. The multidrug resistant bacterium may be on an animate or inanimate surface and both medical and nonmedical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with a multidrug resistant bacterium to overcome resistance to the antibiotic in said multidrug resistant bacterium. In another aspect the method can be used to combat contamination of a site with multidrug resistant bacteria, e.g. for disinfection and cleaning purposes.
IN42DEN2012 2009-06-03 2010-06-03 IN2012DN00042A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0909557A GB0909557D0 (en) 2009-06-03 2009-06-03 Anti-microbial alginate oligomers
GB0913829A GB0913829D0 (en) 2009-08-07 2009-08-07 Treatment of acinetobacter with alginate oligomers and macrolide antibiotics
GB0917995A GB0917995D0 (en) 2009-10-14 2009-10-14 Alginate oligomers for use in overcoming multidrug resistance in bacteria
PCT/GB2010/001097 WO2010139957A1 (en) 2009-06-03 2010-06-03 Alginate oligomers for use in overcoming multidrug resistance in bacteria

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11672818B2 (en) 2018-03-06 2023-06-13 The University Of North Carolina At Chapel Hill Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
US11697693B2 (en) 2017-01-03 2023-07-11 The University Of North Carolina At Chapel Hill Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101917850B (en) 2007-10-25 2016-01-13 森普拉制药公司 The preparation method of macrolide antibacterial agents
CA2706637C (en) * 2007-11-27 2016-11-29 Algipharma Ipr As Use of alginate oligomers in combating biofilms
CN102344898B (en) * 2011-10-19 2013-03-13 黑龙江大学 Klebsiella variicola strain
US10039777B2 (en) 2012-03-20 2018-08-07 Neuro-Lm Sas Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
KR20140139083A (en) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. Parenteral formulations for administering macrolide antibiotics
KR101438969B1 (en) * 2012-12-27 2014-09-11 현대자동차주식회사 Pseudomonas nitroreducens for Odorless Bioflim-Coated Evaporator Core and uses thereof
US9993497B2 (en) 2012-12-30 2018-06-12 Hadasit Medical Research Services And Development Ltd. Use of alginate compositions in preventing or reducing liver damage caused by a hepatotoxic agent
JP2016521752A (en) * 2013-06-13 2016-07-25 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル Compositions and methods for the treatment of Burkholderia infections
KR101502773B1 (en) * 2013-07-25 2015-03-24 조선대학교산학협력단 A novel bifunctional peptide and its use with antimicrobial activity and anti inflammatory action from Bacillus strain
GB201322777D0 (en) 2013-12-20 2014-02-05 Algipharma As Use of alginate oligomers as blood anticoagulants
EP3110426A1 (en) * 2014-02-28 2017-01-04 Algipharma As Use of alginate oligomers in the treatment of cystic fibrosis and other conditions associated with defective cftr ion channel function
GB201415381D0 (en) * 2014-08-29 2014-10-15 Algipharma As Inhalable powder formulations of alginate oligomers
GB201504878D0 (en) 2015-03-23 2015-05-06 Algipharma As Use of alginate oligomers and CFTR modulators in the treatment of conditions associated with CFTR dysfuntion
JP2017055716A (en) * 2015-09-17 2017-03-23 国立大学法人名古屋大学 Plate for screening multidrug-resistant bacteria, method for detecting multidrug-resistant bacteria, kit for detecting multidrug-resistant bacteria, and liquid medium for screening multidrug-resistant bacteria
GB201517639D0 (en) 2015-10-06 2015-11-18 Algipharma As Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract
WO2017066719A2 (en) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents
RU2631106C1 (en) * 2016-05-06 2017-09-18 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Method for removable prostheses manufacture
US10201518B2 (en) 2016-09-28 2019-02-12 The University Of Hong Kong Bismuth(III) compounds and methods thereof
GB2555391B (en) * 2016-10-21 2019-06-26 Algipharma As Bacitracin-alginate oligomer conjugates
KR20190072579A (en) * 2016-10-21 2019-06-25 알지파마 에이에스 Polymyxin-Alginate Oligomer Conjugate
EP3592364A1 (en) * 2017-03-07 2020-01-15 Cempra Pharmaceuticals, Inc. Compositions and methods for treating dry eye diseases
EP3600338A4 (en) 2017-03-28 2020-10-28 The University of North Carolina at Chapel Hill Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto
FR3072246B1 (en) * 2017-10-13 2020-06-12 Biodesiv Efnium ANTIMICROBIAL POLYMER FOR ANIMAL SEEDS
CN108948005A (en) * 2018-07-03 2018-12-07 湖南华腾制药有限公司 Polyethyleneglycol modified Enoxacin and application
GB201812473D0 (en) 2018-07-31 2018-09-12 Algipharma As Method for the qualitative and quantitative detection of alginate oligomers in body fluids
CN108863618A (en) * 2018-09-19 2018-11-23 贵州大学 A kind of tea tree selenium-rich liquid bacterial manure and the preparation method and application thereof
CA3124673A1 (en) 2018-12-28 2020-07-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto
CN111218464A (en) * 2019-07-01 2020-06-02 中国科学院海洋研究所 Kelp mannuronic acid C5-isomerase gene and application thereof
CN110499353B (en) * 2019-08-09 2023-11-07 佛山市第四人民医院(佛山市结核病防治所) Microbial marker for tuberculosis drug resistance diagnosis and application thereof
CN111172144A (en) * 2019-12-27 2020-05-19 华南农业大学 Microbial agent for efficiently degrading tetracycline antibiotics and application of microbial agent in soil pollution remediation
WO2022147148A1 (en) * 2020-12-30 2022-07-07 Trellis Bioscience, Inc. Therapeutic protein formulations comprising anti-dnabii antibodies and uses thereof
CN114410693B (en) * 2021-12-08 2023-08-04 中南大学 Biological iron-manganese oxide, preparation method thereof and application thereof in simultaneous removal of arsenic and antimony in wastewater
WO2023129726A2 (en) * 2021-12-30 2023-07-06 Sigilon Therapeutics, Inc. Modified polysaccharide polymers and related compositions and methods thereof
CN114349174B (en) * 2022-01-17 2022-10-04 大连理工大学 Method for removing tetracycline based on algae-bacteria complex
CN117185499B (en) * 2023-11-08 2024-01-30 北京大学 Synechocystis PCC 6803 capable of tolerating sulfonamide antibiotics and application thereof
CN117838672B (en) * 2024-03-07 2024-05-10 山东第二医科大学 Tilmicosin/G-type brown alginate oligosaccharide aerosol inhalation nanometer suspension and preparation method thereof

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297511A (en) 1956-12-20
FR7576M (en) 1968-03-27 1970-01-05
HU172831B (en) 1976-03-31 1978-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing complex compounds of oligo- and polygalacturonic acids with essential metal ions
NZ196348A (en) * 1980-03-07 1984-08-24 Interx Research Corp Enhancement of absorption rate of orally administered antibiotics
DD268865A1 (en) 1987-01-16 1989-06-14 Adw Ddr PROCESS FOR PREPARING A PHARMACEUTICAL PREPARATORY
US4898852A (en) 1987-06-02 1990-02-06 Walsh William E Cyclopolgalcturonic acid composition and treatment
US4855128A (en) 1988-01-14 1989-08-08 Warner-Lambert Company Saccharide inhibition of dental plaque
GB8803157D0 (en) 1988-02-11 1988-03-09 Nat Res Dev Denture protection
WO1991011205A1 (en) 1990-01-23 1991-08-08 Trancel Corporation Mannuronic acid containing alginate wound healing composition and method
US5169840A (en) 1991-03-27 1992-12-08 Nobipols Forskningsstiftelse Diequatorially bound β-1, 4 polyuronates and use of same for cytokine stimulation
US5166137A (en) 1991-03-27 1992-11-24 Nobipols Forskningsstiftelse Guluronic acid polymers and use of same for inhibition of cytokine production
JPH05252970A (en) 1991-10-04 1993-10-05 Maruha Corp Production of alginic acid oligosaccharide having bacteriostatic action and bacteriostatic agent containing the substance as active component
CA2106609A1 (en) 1992-09-28 1994-03-29 Irene Yeatman Aldridge Proteases to inhibit and remove biofilm
GB9221163D0 (en) 1992-10-08 1992-11-25 Nobipol And Protan Biopolymer Dna compounds
DE4330773A1 (en) 1993-09-10 1995-03-16 Laevosan Gmbh & Co Kg Blocking the attachment of germs to human cells
AUPM322393A0 (en) 1993-12-24 1994-01-27 Austin Research Institute, The Mucin carbohydrate compounds and their use in immunotherapy
DE69637625D1 (en) 1995-10-19 2008-09-18 Bio Origyn Llc METHODS AND COMPOSITIONS THAT IMPROVE THE SURVIVAL AND FUNCTION OF GERMAN CELLS AND EMBRYOS
JP3512553B2 (en) 1996-01-30 2004-03-29 ポーラ化成工業株式会社 Constipation inhibitor and composition containing it
NO305441B1 (en) 1996-07-12 1999-05-31 Norsk Hydro As Use of G-block polysaccharides
CN1197584C (en) 1997-04-30 2005-04-20 雷克特本克斯尔保健(英国)有限公司 Pourable alginate compositions
NO305033B1 (en) 1997-05-09 1999-03-22 Algipharma As Process for the preparation of uric acid blocks from alginate
GB2325233B (en) 1997-05-16 2001-07-18 Norsk Hydro As Substrates having bound polysaccharides and bacterial nucleic acids
US6339075B1 (en) 1997-06-30 2002-01-15 The University Of British Columbia Use of dextran and other polysaccharides to improve mucus clearance
KR100322511B1 (en) 1998-11-13 2002-10-25 한국해양연구원 Red tide remover and remedy for disease of fishes using alginate polygalacturonite oligomer derivatives
US20040224922A1 (en) 1999-08-26 2004-11-11 Malcolm King Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
EP1212047A2 (en) 1999-08-26 2002-06-12 The Governors Of The University Of Alberta Use of charged dextran as a mucoactive agent and methods and pharmaceutical compositions relating thereto
AU7434200A (en) 1999-09-23 2001-04-24 Reckitt Benckiser (Uk) Limited Method for combating hard water and scale by using algins
RU2167654C1 (en) * 2000-02-15 2001-05-27 Башкирский государственный университет Method of enhancement of antibiotic therapy effectiveness
DE10006989A1 (en) 2000-02-16 2001-08-23 Nutricia Nv Pharmaceutical or dietetic preparation for preventing cellular adhesion of pathogens, e.g. in treatment of infections, comprising carbohydrate having double bond-containing terminal uronic acid unit
RU2274442C2 (en) 2000-03-07 2006-04-20 Раш-Презбитериан-Ст. Лук'С Медикал Сентер Compositions and methods for entrapping and inactivation of pathogenic microorganisms and spermatozoids
GB0005743D0 (en) 2000-03-10 2000-05-03 Reckitt & Colmann Prod Ltd Pharmaceutical compositions including alginates
DE10019076A1 (en) 2000-04-06 2001-10-18 Lang Christine Use of polygalacturonides as food additives
IL156596A0 (en) 2000-12-27 2004-01-04 Salus Pharma Inc Inhalable aztreonam for treatment and prevention of pulmonary bacterial infections
ITMI20010347A1 (en) 2001-02-21 2002-08-21 Grisotech S A IMMUNOGLOBULIN AND POLYSACCHARID COMPLEXES FOR ORAL ABSORPTION ETRANS-MUCOSAL
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
NO324131B1 (en) 2001-11-30 2007-09-03 Fmc Biopolymer As Process for the preparation of alginate having a high mannuronic acid content
NO326145B1 (en) 2001-11-30 2008-10-06 Fmc Biopolymer As Method of stimulating weight gain in mammals, birds and reptiles.
US6610331B1 (en) 2002-05-30 2003-08-26 Scott M. Sweazy Fertility kit
NO20023581D0 (en) 2002-07-26 2002-07-26 Fmc Biopolymer As New mutant strains of Pseudomonas fluorescence and variants thereof, methods of production and use thereof for the production of alginate
GB0300597D0 (en) 2003-01-10 2003-02-12 Microbiological Res Authority Phage biofilms
DE602004025824D1 (en) 2003-09-08 2010-04-15 Fmc Biopolymer As GEL FOAM ON BIOPOLYMER BASE
JP2005145885A (en) 2003-11-14 2005-06-09 Japan Science & Technology Agency Immunologic mechanism activator comprising alginic acid oligomer
CN101001635A (en) 2003-12-04 2007-07-18 生物膜策略公司 Methods and compositions for preventing biofilm formation, reducing existing biofilms, and for reducing populations of bacteria
JP5367266B2 (en) 2004-10-12 2013-12-11 エフエムシー バイオポリマー エイエス Self-gelling alginate system and use thereof
EP1714660A1 (en) 2005-04-21 2006-10-25 N.V. Nutricia Uronic acid and probiotics
EP1879589A2 (en) * 2005-05-13 2008-01-23 Venus Remedies Limited Treatment and control of severe infections including cystic fibrosis
EP1745705A1 (en) 2005-07-20 2007-01-24 N.V. Nutricia Process for preparing uronic acid oligosaccharides by extrusion
GB2430881B (en) 2005-10-06 2010-10-13 Ntnu Technology Transfer As Oligoelectrolyte polyols for the treatment of mucosal hyperviscosity
JP5248492B2 (en) 2006-07-14 2013-07-31 エフエムシー バイオポリマー エイエス Hydrogels containing low molecular weight alginate and biostructures made therefrom
DE102006059510A1 (en) 2006-12-14 2008-06-19 Grünenthal GmbH Coated pellets
WO2008082948A2 (en) 2006-12-29 2008-07-10 Bausch & Lomb Incorporated Ophthalmic alginate composition related methods of manufacture and methods of use
GB0707096D0 (en) 2007-04-12 2007-05-23 Ntnu Technology Transfer As Method
JP2008285431A (en) 2007-05-16 2008-11-27 Japan Science & Technology Agency Composition for preventing and treating viral infectious disease of cultured fish
US20090036554A1 (en) 2007-08-01 2009-02-05 Burke Susan E Ophthalmic compositions comprising a terpene compound
US20090036404A1 (en) 2007-08-02 2009-02-05 Macleod Steven K Ophthalmic compositions comprising a carboxyl-modified fructan or a salt thereof
CA2706637C (en) * 2007-11-27 2016-11-29 Algipharma Ipr As Use of alginate oligomers in combating biofilms

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11697693B2 (en) 2017-01-03 2023-07-11 The University Of North Carolina At Chapel Hill Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto
US11672818B2 (en) 2018-03-06 2023-06-13 The University Of North Carolina At Chapel Hill Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto

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