IL99877A - Process for cleavage of esters during the production of cephalosporins - Google Patents
Process for cleavage of esters during the production of cephalosporinsInfo
- Publication number
- IL99877A IL99877A IL99877A IL9987791A IL99877A IL 99877 A IL99877 A IL 99877A IL 99877 A IL99877 A IL 99877A IL 9987791 A IL9987791 A IL 9987791A IL 99877 A IL99877 A IL 99877A
- Authority
- IL
- Israel
- Prior art keywords
- amino
- formula
- hydrogen
- alkyl
- alkoxy
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
- 238000003776 cleavage reaction Methods 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 230000007017 scission Effects 0.000 title 1
- -1 cyano, carboxy Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/608,772 US5095107A (en) | 1990-11-05 | 1990-11-05 | Process for cleavage of esters during the production of cephalosporins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL99877A0 IL99877A0 (en) | 1992-08-18 |
| IL99877A true IL99877A (en) | 1997-04-15 |
Family
ID=24437931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL99877A IL99877A (en) | 1990-11-05 | 1991-10-28 | Process for cleavage of esters during the production of cephalosporins |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5095107A (index.php) |
| EP (1) | EP0485103A3 (index.php) |
| JP (1) | JPH04273875A (index.php) |
| KR (1) | KR920009821A (index.php) |
| BR (1) | BR9104802A (index.php) |
| CA (1) | CA2054451A1 (index.php) |
| HU (1) | HU209303B (index.php) |
| IE (1) | IE913846A1 (index.php) |
| IL (1) | IL99877A (index.php) |
| MX (1) | MX9101921A (index.php) |
| TW (1) | TW238310B (index.php) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5239068A (en) * | 1987-07-31 | 1993-08-24 | Eli Lilly And Company | Bicyclic β-lactam antibiotics |
| US5142039A (en) * | 1987-07-31 | 1992-08-25 | Eli Lilly And Company | β-lactam antibiotics |
| US5302711A (en) * | 1992-02-18 | 1994-04-12 | Eli Lilly And Company | Ester cleavage process for use with β-lactams |
| US5521307A (en) * | 1992-02-18 | 1996-05-28 | Eli Lilly And Company | Methods and compounds for the preparation of carbacephems |
| IT1271404B (it) * | 1993-08-09 | 1997-05-28 | Hi Chem S P A | Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico |
| US5604222A (en) | 1993-12-27 | 1997-02-18 | Lupin Laboratories, Ltd. | Method for the preparation of 2-chloro sulfinyl azetidinones |
| US5578721A (en) | 1994-07-11 | 1996-11-26 | Lupin Laboratories Limited | Process for preparation of 3-exomethylene cepham sulfoxide esters |
| WO1995035020A2 (en) * | 1994-07-22 | 1995-12-28 | Antibioticos S.P.A. | Glutaryl 7-aca derivatives and processes for obtaining them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1546757A (en) * | 1975-04-10 | 1979-05-31 | Lilly Industries Ltd | Crystalline cephalosporin salts |
| US5043439A (en) * | 1990-03-08 | 1991-08-27 | Bristol-Myers Squibb Company | Process for production of cephalosporins |
-
1990
- 1990-11-05 US US07/608,772 patent/US5095107A/en not_active Expired - Fee Related
-
1991
- 1991-10-28 TW TW080108437A patent/TW238310B/zh active
- 1991-10-28 IL IL99877A patent/IL99877A/xx not_active IP Right Cessation
- 1991-10-29 EP EP19910309991 patent/EP0485103A3/en not_active Withdrawn
- 1991-10-29 CA CA002054451A patent/CA2054451A1/en not_active Abandoned
- 1991-10-30 JP JP3284287A patent/JPH04273875A/ja active Pending
- 1991-11-01 KR KR1019910019398A patent/KR920009821A/ko not_active Abandoned
- 1991-11-04 HU HU913464A patent/HU209303B/hu not_active IP Right Cessation
- 1991-11-04 IE IE384691A patent/IE913846A1/en not_active Application Discontinuation
- 1991-11-04 BR BR919104802A patent/BR9104802A/pt not_active Application Discontinuation
- 1991-11-05 MX MX9101921A patent/MX9101921A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU209303B (en) | 1994-04-28 |
| KR920009821A (ko) | 1992-06-25 |
| MX9101921A (es) | 1992-07-08 |
| US5095107A (en) | 1992-03-10 |
| HUT59686A (en) | 1992-06-29 |
| IL99877A0 (en) | 1992-08-18 |
| CA2054451A1 (en) | 1992-05-06 |
| BR9104802A (pt) | 1992-09-15 |
| HU913464D0 (en) | 1992-01-28 |
| EP0485103A2 (en) | 1992-05-13 |
| TW238310B (index.php) | 1995-01-11 |
| IE913846A1 (en) | 1992-05-22 |
| JPH04273875A (ja) | 1992-09-30 |
| EP0485103A3 (en) | 1992-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |