IL99068A0 - Non-nucleotide linker reagents for oligomers - Google Patents

Non-nucleotide linker reagents for oligomers

Info

Publication number
IL99068A0
IL99068A0 IL99068A IL9906891A IL99068A0 IL 99068 A0 IL99068 A0 IL 99068A0 IL 99068 A IL99068 A IL 99068A IL 9906891 A IL9906891 A IL 9906891A IL 99068 A0 IL99068 A0 IL 99068A0
Authority
IL
Israel
Prior art keywords
oligomers
nucleotide linker
linker reagents
reagents
nucleotide
Prior art date
Application number
IL99068A
Other versions
IL99068A (en
Original Assignee
Genta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genta Inc filed Critical Genta Inc
Publication of IL99068A0 publication Critical patent/IL99068A0/en
Publication of IL99068A publication Critical patent/IL99068A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/26—Amides of acids of phosphorus containing P-halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL99068A 1990-08-09 1991-08-02 Non-nucleotide linker reagent for oligomers IL99068A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56530790A 1990-08-09 1990-08-09

Publications (2)

Publication Number Publication Date
IL99068A0 true IL99068A0 (en) 1992-07-15
IL99068A IL99068A (en) 1998-01-04

Family

ID=24258038

Family Applications (1)

Application Number Title Priority Date Filing Date
IL99068A IL99068A (en) 1990-08-09 1991-08-02 Non-nucleotide linker reagent for oligomers

Country Status (9)

Country Link
EP (1) EP0542928A4 (en)
JP (1) JPH05507419A (en)
KR (1) KR930701468A (en)
AU (1) AU664542B2 (en)
CA (1) CA2089087A1 (en)
IE (1) IE912805A1 (en)
IL (1) IL99068A (en)
NZ (1) NZ239250A (en)
WO (1) WO1992002532A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL99069A (en) * 1990-08-09 1998-08-16 Genta Inc Psoralen conjugated methylphosphonate oligonucleotides
DE4239531A1 (en) * 1992-11-25 1994-05-26 Gabor Dr Igloi Reagent for coupling various substances to nucleic acids and process for its production
WO1994027615A1 (en) * 1993-05-26 1994-12-08 Genta Incorporated Oligomer conjugates and their use
EP0735899A4 (en) * 1993-11-16 1998-10-21 Genta Inc Synthetic oligomers having phosphonate internucleosidyl linkages of undefined chirality mixed with non-phosphonate internucleosidyl linkages
US5955597A (en) * 1993-11-16 1999-09-21 Genta, Incorporated Chirally enriched synthetic phosphate oligomers
CA2176372A1 (en) * 1993-11-16 1995-05-26 Lyle John Arnold, Jr. Chirally enriched synthetic phosphonate oligomers
CA2176256A1 (en) * 1993-11-16 1995-05-26 Lyle John Arnold, Jr. Synthetic oligomers having chirally pure phosphonate internucleosidyl linkages mixed with non-phosphonate internucleosidyl linkages
US6184389B1 (en) 1994-01-11 2001-02-06 Isis Pharmaceuticals, Inc. Combinatorial libraries having aminodiol monomer subunits
US6448373B1 (en) 1994-01-11 2002-09-10 Isis Pharmaceuticals, Inc. Phosphate linked oligomers formed of monomeric diols and processes for preparing same
US5886177A (en) * 1994-01-11 1999-03-23 Isis Pharmaceuticals, Inc. Phosphate linked oligomers
US6828427B1 (en) 1994-01-11 2004-12-07 Isis Pharmaceuticals, Inc. Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
US5854410A (en) * 1994-03-31 1998-12-29 Genta Incorporated Oligonucleoside cleavage compounds and therapies
IT1270694B (en) * 1994-11-15 1997-05-07 Italfarmaco Spa FLUORENYL-HYDROXAMIC DERIVATIVES FOR IMMUNOSOPPRESSIVE AND ANTI-INFLAMMATORY ACTIVITIES
US5919965A (en) * 1995-01-18 1999-07-06 Genzyme Corporation Non-nucleotide phosphorus ester oligomers
US6211354B1 (en) * 1998-05-06 2001-04-03 Tosch Corporation Optically active DNA probe having phosphonic diester linkage
EP2544688B1 (en) 2010-03-02 2016-09-07 President and Fellows of Harvard College Methods and compositions for treatment of angelman syndrome
JP6081995B2 (en) 2011-06-17 2017-02-15 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Frizzled2 as a target for therapeutic antibodies in the treatment of cancer
EP2724156B1 (en) 2011-06-27 2017-08-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
US20140178877A1 (en) * 2012-12-20 2014-06-26 Roche Molecular Systems, Inc. Labeled Oligonucleotide Probes Used for Nucleic Acid Sequence Analysis
CA2908379C (en) 2013-03-28 2021-03-30 Japan Advanced Institute Of Science And Technology Photoresponsive nucleotide analogue having photocrosslinking ability
JP6920689B2 (en) 2017-07-26 2021-08-18 日華化学株式会社 Photoreactive nucleotide analogs that can be photocrosslinked in the visible light region
WO2019022158A1 (en) 2017-07-26 2019-01-31 国立大学法人北陸先端科学技術大学院大学 Photoresponsive nucleotide analog capable of photocrosslinking in visible light region

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3440190A (en) * 1965-09-08 1969-04-22 Du Pont Oligonucleotide compositions and the process for the preparation thereof
FR2565996B1 (en) * 1984-06-15 1988-01-22 Inst Nat Sante Rech Med CHEMICALLY MARKED NUCLEIC ACIDS, THEIR USE AND THE NECESSARY FOR ITS IMPLEMENTATION
US4757141A (en) * 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
KR970005898B1 (en) * 1987-09-21 1997-04-21 젠- 프로우브 인코퍼레이티드 Non-nucleotide linking reagents for nucleotide rpobes
FR2642074B1 (en) * 1989-01-20 1994-04-29 Oris Ind POLYHYDROXYLATED MOLECULE DERIVATIVES FOR THE INTRODUCTION OF AT LEAST ONE BRANCH INTO AN OLIGONUCLEOTIDE

Also Published As

Publication number Publication date
WO1992002532A1 (en) 1992-02-20
NZ239250A (en) 1993-12-23
IL99068A (en) 1998-01-04
AU664542B2 (en) 1995-11-23
JPH05507419A (en) 1993-10-28
IE912805A1 (en) 1992-02-12
CA2089087A1 (en) 1992-02-10
EP0542928A1 (en) 1993-05-26
AU9071091A (en) 1992-03-02
KR930701468A (en) 1993-06-11
EP0542928A4 (en) 1994-07-27

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Legal Events

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