IT1270694B - FLUORENYL-HYDROXAMIC DERIVATIVES FOR IMMUNOSOPPRESSIVE AND ANTI-INFLAMMATORY ACTIVITIES - Google Patents

FLUORENYL-HYDROXAMIC DERIVATIVES FOR IMMUNOSOPPRESSIVE AND ANTI-INFLAMMATORY ACTIVITIES

Info

Publication number
IT1270694B
IT1270694B ITMI942304A ITMI942304A IT1270694B IT 1270694 B IT1270694 B IT 1270694B IT MI942304 A ITMI942304 A IT MI942304A IT MI942304 A ITMI942304 A IT MI942304A IT 1270694 B IT1270694 B IT 1270694B
Authority
IT
Italy
Prior art keywords
immunosoppressive
fluorenyl
inflammatory activities
hydroxamic derivatives
hydroxamic
Prior art date
Application number
ITMI942304A
Other languages
Italian (it)
Inventor
Giorgio Bertolini
Mario Aquino
Francesca Chiaffarino
Gianni Gromo
Alberto Sala
Marinella Valtolina
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Priority to ITMI942304A priority Critical patent/IT1270694B/en
Publication of ITMI942304A0 publication Critical patent/ITMI942304A0/en
Priority to PCT/EP1995/004388 priority patent/WO1996015105A1/en
Priority to AU39276/95A priority patent/AU3927695A/en
Priority to IL11599695A priority patent/IL115996A0/en
Priority to ZA959666A priority patent/ZA959666B/en
Publication of ITMI942304A1 publication Critical patent/ITMI942304A1/en
Application granted granted Critical
Publication of IT1270694B publication Critical patent/IT1270694B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Abstract

Derivati idrossammici di fluorenilamminoacidi di formula I (FORMULA I) dove n = O-3; R1 e R2 sono indipendentemente idrogeno, alchile, alogeno, idrossi, idrossialchile o alcossi; A è alchilidene, fenilachilidene, fenilene o naftilene; sono utili come agenti immunosoppressori ed antiinfiammatori.Hydroxamic derivatives of fluorenylaminoacids of formula I (FORMULA I) where n = O-3; R1 and R2 are independently hydrogen, alkyl, halogen, hydroxy, hydroxyalkyl or alkoxy; A is alkylidene, phenylachylidene, phenylene or naphthylene; they are useful as immunosuppressive and anti-inflammatory agents.

ITMI942304A 1994-11-15 1994-11-15 FLUORENYL-HYDROXAMIC DERIVATIVES FOR IMMUNOSOPPRESSIVE AND ANTI-INFLAMMATORY ACTIVITIES IT1270694B (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ITMI942304A IT1270694B (en) 1994-11-15 1994-11-15 FLUORENYL-HYDROXAMIC DERIVATIVES FOR IMMUNOSOPPRESSIVE AND ANTI-INFLAMMATORY ACTIVITIES
PCT/EP1995/004388 WO1996015105A1 (en) 1994-11-15 1995-11-08 Fluorenyl-hydroxamic derivatives endowed with immunosuppressive and anti-inflammatory activity
AU39276/95A AU3927695A (en) 1994-11-15 1995-11-08 Fluorenyl-hydroxamic derivatives endowed with immunosuppressive and anti-inflammatory activity
IL11599695A IL115996A0 (en) 1994-11-15 1995-11-14 Fluorenyl-hydroxamic derivatives endowed with immunosuppresive and anti-inflammatory activity
ZA959666A ZA959666B (en) 1994-11-15 1995-11-14 Fluorenyl-hydroxamic derivatives endowed with immuno-suppressive and entinflammatory activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI942304A IT1270694B (en) 1994-11-15 1994-11-15 FLUORENYL-HYDROXAMIC DERIVATIVES FOR IMMUNOSOPPRESSIVE AND ANTI-INFLAMMATORY ACTIVITIES

Publications (3)

Publication Number Publication Date
ITMI942304A0 ITMI942304A0 (en) 1994-11-15
ITMI942304A1 ITMI942304A1 (en) 1996-05-15
IT1270694B true IT1270694B (en) 1997-05-07

Family

ID=11369849

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI942304A IT1270694B (en) 1994-11-15 1994-11-15 FLUORENYL-HYDROXAMIC DERIVATIVES FOR IMMUNOSOPPRESSIVE AND ANTI-INFLAMMATORY ACTIVITIES

Country Status (5)

Country Link
AU (1) AU3927695A (en)
IL (1) IL115996A0 (en)
IT (1) IT1270694B (en)
WO (1) WO1996015105A1 (en)
ZA (1) ZA959666B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20030025A1 (en) 2003-01-10 2004-07-11 Italfarmaco Spa HYDROXAMIC ACID DERIVATIVES FOR ANTI-INFLAMMATORY ACTIVITY.
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0129075A3 (en) * 1983-05-20 1985-08-28 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Protected amino acid derivatives and their preparation
US5079260A (en) * 1989-06-22 1992-01-07 Nova Pharmaceutical Corporation Method for treating inflammation and compounds and compositions suitable for use therein
NZ239250A (en) * 1990-08-09 1993-12-23 Genta Inc Chirally pure non-nucleotide reagents for use in preparing

Also Published As

Publication number Publication date
ZA959666B (en) 1996-05-29
ITMI942304A0 (en) 1994-11-15
IL115996A0 (en) 1996-01-31
WO1996015105A1 (en) 1996-05-23
AU3927695A (en) 1996-06-06
ITMI942304A1 (en) 1996-05-15

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971126