IL95052A0 - Phosphonic acid derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same - Google Patents

Phosphonic acid derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same

Info

Publication number
IL95052A0
IL95052A0 IL95052A IL9505290A IL95052A0 IL 95052 A0 IL95052 A0 IL 95052A0 IL 95052 A IL95052 A IL 95052A IL 9505290 A IL9505290 A IL 9505290A IL 95052 A0 IL95052 A0 IL 95052A0
Authority
IL
Israel
Prior art keywords
processes
preparation
same
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL95052A
Other languages
English (en)
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IL95052A0 publication Critical patent/IL95052A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • C07F9/4012Esters of acyclic acids which can have further substituents on alkyl substituted by B, Si, P or a metal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3821Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL95052A 1989-07-17 1990-07-12 Phosphonic acid derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same IL95052A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38143489A 1989-07-17 1989-07-17

Publications (1)

Publication Number Publication Date
IL95052A0 true IL95052A0 (en) 1991-06-10

Family

ID=23505003

Family Applications (1)

Application Number Title Priority Date Filing Date
IL95052A IL95052A0 (en) 1989-07-17 1990-07-12 Phosphonic acid derivatives,processes for the preparation thereof,and pharmaceutical compositions containing the same

Country Status (10)

Country Link
EP (1) EP0409181A3 (fr)
JP (1) JPH0368591A (fr)
KR (1) KR910002882A (fr)
AU (1) AU635545B2 (fr)
CA (1) CA2018470A1 (fr)
HU (1) HU210560B (fr)
IE (1) IE902578A1 (fr)
IL (1) IL95052A0 (fr)
NZ (1) NZ234502A (fr)
ZA (1) ZA905481B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506262A (en) * 1991-05-10 1996-04-09 Merck & Co., Inc. Cholesterol lowering compounds
CA2067974A1 (fr) * 1991-05-13 1992-11-14 Scott A. Biller Methode pour abaisser le taux de cholesterol grace a un phosphonomethylphosphinate, inhibiteur de la squalene synthetase
ES2080452T3 (es) * 1991-10-11 1996-02-01 Squibb & Sons Inc Uso de bifosfonatos para la fabricacion de un medicamento para el bloqueo de la transformacion neoplasica de celulas inducida por oncogenes ras.
US5278153A (en) * 1992-05-18 1994-01-11 E. R. Squibb & Sons, Inc. Aryl and heteroaryl (phosphinylmethyl)phosphonate squalene synthetase inhibitors and method
US5283256A (en) * 1992-07-22 1994-02-01 Merck & Co., Inc. Cholesterol-lowering agents
US5254544A (en) * 1992-09-25 1993-10-19 E. R. Squibb & Sons, Inc. Hydroxyphosphinyl phosphonate squalene synthetase inhibitors and method
US5332728A (en) * 1992-11-23 1994-07-26 Bristol-Myers Squibb Company Method for treating a fungal infection
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
DE69837610T2 (de) * 1997-07-31 2008-01-03 Kos Life Sciences, Inc., Weston Manteltablette enthaltend nikotinsäure oder einen stoff, der zu nikotinsäure metabolisiert wird in verzögert freigesetzter form und einen hmg-coa reduktasehemmer im mantel zur sofortigen freisetzung
BR112015023377A2 (pt) * 2013-03-15 2017-07-18 Procter & Gamble materiais funcionais insaturados e ramificados específicos para uso em produtos de consumo
US9528269B2 (en) 2014-06-09 2016-12-27 Johns Manville Roofing systems and roofing boards with non-halogenated fire retardant
US9815256B2 (en) 2014-06-09 2017-11-14 Johns Manville Foam boards including non-halogenated fire retardants
US9523195B2 (en) 2014-06-09 2016-12-20 Johns Manville Wall insulation boards with non-halogenated fire retardant and insulated wall systems
US9815966B2 (en) 2014-07-18 2017-11-14 Johns Manville Spray foams containing non-halogenated fire retardants

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE53128B1 (en) * 1981-06-19 1988-07-06 Monsanto Co Herbicidally active monoesters and diesters of n-alkyl substituted amino methyl phosphonic acid and process for preparing the diesters
FR2576024B1 (fr) * 1985-01-14 1988-01-08 Rhone Poulenc Agrochimie Herbicides de type n - (phosphonomethylglycyl) sulfonylamines
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
US4871721A (en) * 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
CA2016467A1 (fr) * 1989-06-05 1990-12-05 Martin Eisman Methode de traitement de l'atherosclerose des vaisseaux peripheriques a l'aide d'un inhibiteur de l'hmg coa reductase et (ou) d'un inhibiteur de la squalene synthetase

Also Published As

Publication number Publication date
AU5900290A (en) 1991-01-17
KR910002882A (ko) 1991-02-26
EP0409181A3 (en) 1991-04-10
NZ234502A (en) 1994-09-27
CA2018470A1 (fr) 1991-01-17
HU210560B (en) 1995-05-29
IE902578A1 (en) 1991-02-27
AU635545B2 (en) 1993-03-25
JPH0368591A (ja) 1991-03-25
HUT54378A (en) 1991-02-28
ZA905481B (en) 1991-04-24
EP0409181A2 (fr) 1991-01-23
HU904226D0 (en) 1990-12-28

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