IL94980A - History of Pentapeptide against Harpaz, with a side chain of converted aspartic acid, their preparation and pharmaceutical preparations containing them - Google Patents

History of Pentapeptide against Harpaz, with a side chain of converted aspartic acid, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL94980A
IL94980A IL9498090A IL9498090A IL94980A IL 94980 A IL94980 A IL 94980A IL 9498090 A IL9498090 A IL 9498090A IL 9498090 A IL9498090 A IL 9498090A IL 94980 A IL94980 A IL 94980A
Authority
IL
Israel
Prior art keywords
asp
alkyl
val
hydrogen
phenyl
Prior art date
Application number
IL9498090A
Other languages
English (en)
Hebrew (he)
Other versions
IL94980A0 (en
Original Assignee
Bio Mega Boehringer Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA000605091A external-priority patent/CA1340683C/fr
Priority claimed from CA002019005A external-priority patent/CA2019005C/fr
Application filed by Bio Mega Boehringer Ingelheim filed Critical Bio Mega Boehringer Ingelheim
Publication of IL94980A0 publication Critical patent/IL94980A0/xx
Publication of IL94980A publication Critical patent/IL94980A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
IL9498090A 1989-07-07 1990-07-05 History of Pentapeptide against Harpaz, with a side chain of converted aspartic acid, their preparation and pharmaceutical preparations containing them IL94980A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA000605091A CA1340683C (fr) 1989-07-07 1989-07-07 Pentapeptides antiherpetiques, a chaine laterale constituee d'acide aspartique avec substitution
CA002019005A CA2019005C (fr) 1990-06-14 1990-06-14 Derives pentapeptidiques anti-herpes ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl

Publications (2)

Publication Number Publication Date
IL94980A0 IL94980A0 (en) 1991-06-10
IL94980A true IL94980A (en) 1995-03-15

Family

ID=25672870

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9498090A IL94980A (en) 1989-07-07 1990-07-05 History of Pentapeptide against Harpaz, with a side chain of converted aspartic acid, their preparation and pharmaceutical preparations containing them

Country Status (6)

Country Link
EP (1) EP0411334B1 (fr)
JP (1) JP2877909B2 (fr)
AT (1) ATE118785T1 (fr)
DE (1) DE69017113T2 (fr)
IL (1) IL94980A (fr)
NZ (1) NZ234376A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830864A (en) * 1992-03-12 1998-11-03 Boehringer Ingelheim (Canada), Ltd. Antiherpes peptide derivatives having a ureido n-terminus
EP0560267B1 (fr) 1992-03-12 1998-08-19 Boehringer Ingelheim (Canada) Ltd. Dérivés peptidiques isostères contre l'herpès
US5846941A (en) * 1992-03-12 1998-12-08 Boehringer Ingelheim (Canada) Ltd. Isosteric antiherpes peptide derivatives II
DK0618226T3 (da) * 1993-03-03 2000-12-27 Boehringer Ingelheim Ca Ltd Inhibitorer for ibonucleotid-reduktase fra herpes-vira
CA2152541C (fr) * 1995-06-23 1998-12-15 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Inhibiteurs de la ribonucleotide reductase de l'herpes
US5948935A (en) * 1997-01-23 1999-09-07 Boehringer Ingelheim (Canada) Ltd. Process and intermediates for (s)-α-amino-1-carboxycyclopentaneacetic acid
JP5828217B2 (ja) 2011-04-15 2015-12-02 三菱マテリアル株式会社 ドリル

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795740A (en) * 1986-05-20 1989-01-03 Cohen Eric A Antiviral peptides and means for treating herpes infections
EP0292255A3 (fr) * 1987-05-22 1990-08-22 Merck & Co. Inc. Inhibiteur de ribonucléotide réductase

Also Published As

Publication number Publication date
JP2877909B2 (ja) 1999-04-05
JPH03215497A (ja) 1991-09-20
DE69017113D1 (de) 1995-03-30
NZ234376A (en) 1997-05-26
EP0411334B1 (fr) 1995-02-22
DE69017113T2 (de) 1995-08-03
ATE118785T1 (de) 1995-03-15
EP0411334A1 (fr) 1991-02-06
IL94980A0 (en) 1991-06-10

Similar Documents

Publication Publication Date Title
EP0461546B1 (fr) Dérivés de peptides anti-herpès ayant une extrémité N-terminale contenant un groupe 1,4-dioxo-C4
US6313095B1 (en) Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain
EP0411332B1 (fr) Peptides antiviraux ayant une chaîne latérale 2-cétoalkylique d'acide aminé
EP0411334B1 (fr) Dérivés pentapeptidiques antiherpès ayant une chaîne latérale d'acide aspartique substitué
US5552384A (en) Antiherpes compositions and method of use
US5502036A (en) Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain
EP0408973B1 (fr) Pentapeptides ayant une activité antiherpès
EP0411333B1 (fr) Dérivés tetrapeptidiques antiherpes ayant une chaîne latérale d'acide aspartique substituée
US5149778A (en) Cyclic peptides for treating herpes infections
US5648337A (en) Antiherpes pentapeptides
US5258493A (en) Cyclic peptides for treating herpes infections
CA2019005C (fr) Derives pentapeptidiques anti-herpes ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl
AU6151694A (en) Inhibitors of herpes viral ribonucleotide reductase
CA2019006C (fr) Derives tetrapeptidiques ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl
US5830864A (en) Antiherpes peptide derivatives having a ureido n-terminus
NZ234373A (en) Acylated n-terminal tetrapeptides having an esterified or amidified aspartic acid residue and optionally substituted at the c-terminal by 5-1h-tetrazolyl; use in treatment of herpes virus infections