IL94867A - Metallic-complex pharmaceutical preparations that dissolve in water - Google Patents
Metallic-complex pharmaceutical preparations that dissolve in waterInfo
- Publication number
- IL94867A IL94867A IL9486790A IL9486790A IL94867A IL 94867 A IL94867 A IL 94867A IL 9486790 A IL9486790 A IL 9486790A IL 9486790 A IL9486790 A IL 9486790A IL 94867 A IL94867 A IL 94867A
- Authority
- IL
- Israel
- Prior art keywords
- water
- weight
- composition according
- metallocene complex
- polyol
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 229920005862 polyol Polymers 0.000 claims abstract description 15
- 150000003077 polyols Chemical class 0.000 claims abstract description 15
- 239000000654 additive Substances 0.000 claims abstract description 10
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 3
- 235000014633 carbohydrates Nutrition 0.000 claims abstract description 3
- 150000002334 glycols Chemical class 0.000 claims abstract description 3
- 150000005846 sugar alcohols Chemical class 0.000 claims abstract description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 9
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 9
- MKNXBRLZBFVUPV-UHFFFAOYSA-L cyclopenta-1,3-diene;dichlorotitanium Chemical compound Cl[Ti]Cl.C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 MKNXBRLZBFVUPV-UHFFFAOYSA-L 0.000 claims description 9
- 238000004108 freeze drying Methods 0.000 claims description 9
- 239000000600 sorbitol Substances 0.000 claims description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- YXQWGVLNDXNSJJ-UHFFFAOYSA-N cyclopenta-1,3-diene;vanadium(2+) Chemical class [V+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 YXQWGVLNDXNSJJ-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000006184 cosolvent Substances 0.000 claims description 6
- 229960001760 dimethyl sulfoxide Drugs 0.000 claims description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 5
- 229960004793 sucrose Drugs 0.000 claims description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- 150000001450 anions Chemical class 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- KOMDZQSPRDYARS-UHFFFAOYSA-N cyclopenta-1,3-diene titanium Chemical compound [Ti].C1C=CC=C1.C1C=CC=C1 KOMDZQSPRDYARS-UHFFFAOYSA-N 0.000 claims description 4
- ZSWFCLXCOIISFI-UHFFFAOYSA-N endo-cyclopentadiene Natural products C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- ALQSHHUCVQOPAS-UHFFFAOYSA-N Pentane-1,5-diol Chemical compound OCCCCCO ALQSHHUCVQOPAS-UHFFFAOYSA-N 0.000 claims description 2
- 229920001400 block copolymer Polymers 0.000 claims description 2
- -1 cyclopentadienyl anion Chemical class 0.000 claims description 2
- 235000013681 dietary sucrose Nutrition 0.000 claims description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 2
- 229910052723 transition metal Inorganic materials 0.000 claims description 2
- 150000003624 transition metals Chemical class 0.000 claims description 2
- 229940043375 1,5-pentanediol Drugs 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 abstract description 4
- 230000001085 cytostatic effect Effects 0.000 abstract description 4
- 239000000243 solution Substances 0.000 description 25
- 239000007864 aqueous solution Substances 0.000 description 8
- 238000004090 dissolution Methods 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000007911 parenteral administration Methods 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 238000011275 oncology therapy Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000009210 therapy by ultrasound Methods 0.000 description 3
- KJXKHGDHXCOQTK-UHFFFAOYSA-L cyclopenta-1,3-diene;molybdenum(4+);dichloride Chemical compound [Cl-].[Cl-].[Mo+4].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KJXKHGDHXCOQTK-UHFFFAOYSA-L 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000010981 drying operation Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- RDUAXDDQRLRHQZ-UHFFFAOYSA-N 2-hydroxypropane-1,1,1-tricarboxylic acid Chemical compound CC(O)C(C(O)=O)(C(O)=O)C(O)=O RDUAXDDQRLRHQZ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 101100010166 Mus musculus Dok3 gene Proteins 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- CSEGCHWAMVIXSA-UHFFFAOYSA-L cyclopenta-1,3-diene;hafnium(4+);dichloride Chemical compound [Cl-].[Cl-].[Hf+4].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 CSEGCHWAMVIXSA-UHFFFAOYSA-L 0.000 description 1
- 230000001779 embryotoxic effect Effects 0.000 description 1
- 231100000238 embryotoxicity Toxicity 0.000 description 1
- 230000005496 eutectics Effects 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 150000004820 halides Chemical group 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- QMBQEXOLIRBNPN-UHFFFAOYSA-L zirconocene dichloride Chemical compound [Cl-].[Cl-].[Zr+4].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 QMBQEXOLIRBNPN-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3923270A DE3923270A1 (de) | 1989-07-14 | 1989-07-14 | Wasserloesliche pharmazeutische metallocen-komplex-zusammensetzung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL94867A0 IL94867A0 (en) | 1991-04-15 |
| IL94867A true IL94867A (en) | 1995-01-24 |
Family
ID=6385007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9486790A IL94867A (en) | 1989-07-14 | 1990-06-26 | Metallic-complex pharmaceutical preparations that dissolve in water |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5296237A (fi) |
| EP (1) | EP0407804B1 (fi) |
| JP (1) | JPH03128319A (fi) |
| KR (1) | KR0165676B1 (fi) |
| AT (1) | ATE96665T1 (fi) |
| AU (1) | AU624006B2 (fi) |
| CZ (1) | CZ279046B6 (fi) |
| DD (1) | DD296417A5 (fi) |
| DE (2) | DE3923270A1 (fi) |
| DK (1) | DK0407804T3 (fi) |
| ES (1) | ES2059899T3 (fi) |
| FI (1) | FI95870C (fi) |
| HU (1) | HU208073B (fi) |
| IL (1) | IL94867A (fi) |
| SK (1) | SK278731B6 (fi) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4135291A1 (de) * | 1991-10-25 | 1993-04-29 | Koepf Maier Petra | Cytostatisch wirksame ionische metallocen-komplexe und diese komplexe enthaltende arzneimittel |
| EP0633027B1 (en) * | 1992-10-30 | 2001-10-24 | MARKOV, Gennady Alexandrovich | Compound for the biological stimulation and correction of the phenotype of an organism and a process for producing the same |
| HU212105B (en) * | 1993-03-19 | 1996-02-28 | Nitrokemia Ipartelepek | Process for producing titanium compounds of antitumor activiti and pharmaceutical compositions containing them |
| WO2000035930A1 (en) * | 1998-01-20 | 2000-06-22 | Parker Hughes Institute | Vanadium compounds for treating cancer |
| US6051603A (en) | 1998-01-20 | 2000-04-18 | Wayne Hughes Institute | Vanadium (IV) metallocene complexes having sperm motility inhibiting activity |
| US6432941B1 (en) | 1998-01-20 | 2002-08-13 | Parker Hughes Institute | Vanadium compounds for treating cancer |
| US6245808B1 (en) | 1998-11-05 | 2001-06-12 | Parker Hughes Institute | Oxy-vanadium (IV) complexes having spermicidal activity |
| JPH11214927A (ja) | 1998-01-29 | 1999-08-06 | Murata Mfg Co Ltd | 高周波モジュール |
| KR20020048494A (ko) * | 2000-12-18 | 2002-06-24 | 신형인 | 내 컷팅 및 칩핑성이 향상된 고무조성물 |
| ATE369909T1 (de) * | 2001-06-13 | 2007-09-15 | Beta Technologie Ag | Massenpolymerisation-reaktoren und verfahren zur polymerisation |
| RU2197499C2 (ru) * | 2001-08-23 | 2003-01-27 | Бокованов Владимир Евгеньевич | Металлоценовые производные сахаров и содержащее их средство для активации киллинга микроорганизмов, локализованных внутриклеточно |
| DE10151467A1 (de) | 2001-10-18 | 2003-05-08 | Bayerische Motoren Werke Ag | Schaltgetriebe mit Verriegelungseinrichtung zur Verriegelung einzelner Gänge |
| US20040052690A1 (en) * | 2002-09-12 | 2004-03-18 | Eaton Gerald B. | Polymerization reactant injection system |
| DE102006053690A1 (de) * | 2006-11-13 | 2008-05-15 | Westfälische-Wilhelms Universität Münster | Anionische Cyclopentadienyl-Kohlenhydratverbindungen |
| CA2838387A1 (en) | 2011-06-06 | 2012-12-13 | Chevron Phillips Chemical Company Lp | Use of metallocene compounds for cancer treatment |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2923334C2 (de) * | 1979-06-08 | 1985-03-07 | Hartmut Prof. Dipl.-Chem. Dr. Köpf | Verwendung von Cyclopentadienylmetall-Acido-Komplexen bei der Krebsbekämpfung und diese Komplexe enthaltende Arzneipräparate |
| US4296030A (en) * | 1980-04-09 | 1981-10-20 | American Cyanamid Company | Metal chelates of 1,4-bis(substituted-amino-5,8-dihydroxy-anthraquinones |
| DE3134709A1 (de) * | 1981-09-02 | 1983-03-10 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Antineoplastisch wirkende titanverbindung und diese enthaltende arzneimittel |
| DE3404443A1 (de) * | 1984-02-08 | 1985-08-08 | Hartmut Prof. Dr. 1000 Berlin Köpf | Metallicenium-salze und deren verwendung als cytostatica bei der krebsbekaempfung |
| JPH0662407B2 (ja) * | 1984-12-25 | 1994-08-17 | 株式会社三和化学研究所 | 安定化された３―オキシゲルミルプロピオン酸ポリマーを有効成分とする免疫調整剤 |
| DE3518447A1 (de) * | 1985-05-22 | 1986-11-27 | Hartmut Prof. Dr. 1000 Berlin Köpf | Titanocen-komplexe und deren verwendung als cytostatica bei der krebsbekaempfung |
| JPH0665648B2 (ja) * | 1985-09-25 | 1994-08-24 | 塩野義製薬株式会社 | 白金系抗癌物質の安定な凍結真空乾燥製剤 |
| JPH0269491A (ja) * | 1988-09-05 | 1990-03-08 | Sagami Chem Res Center | チタノセン（４）錯体化合物 |
-
1989
- 1989-07-14 DE DE3923270A patent/DE3923270A1/de active Granted
-
1990
- 1990-06-26 IL IL9486790A patent/IL94867A/en not_active IP Right Cessation
- 1990-06-26 AU AU57879/90A patent/AU624006B2/en not_active Ceased
- 1990-06-26 DK DK90112105.3T patent/DK0407804T3/da active
- 1990-06-26 AT AT90112105T patent/ATE96665T1/de not_active IP Right Cessation
- 1990-06-26 DE DE90112105T patent/DE59003304D1/de not_active Expired - Fee Related
- 1990-06-26 EP EP90112105A patent/EP0407804B1/de not_active Expired - Lifetime
- 1990-06-26 ES ES90112105T patent/ES2059899T3/es not_active Expired - Lifetime
- 1990-06-28 KR KR1019900009662A patent/KR0165676B1/ko not_active IP Right Cessation
- 1990-07-11 DD DD90342670A patent/DD296417A5/de not_active IP Right Cessation
- 1990-07-13 CZ CS903490A patent/CZ279046B6/cs unknown
- 1990-07-13 HU HU904199A patent/HU208073B/hu not_active IP Right Cessation
- 1990-07-13 SK SK3490-90A patent/SK278731B6/sk unknown
- 1990-07-13 JP JP2186977A patent/JPH03128319A/ja active Pending
- 1990-07-13 FI FI903573A patent/FI95870C/fi not_active IP Right Cessation
-
1991
- 1991-12-19 US US07/810,449 patent/US5296237A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE96665T1 (de) | 1993-11-15 |
| FI903573A0 (fi) | 1990-07-13 |
| HUT55224A (en) | 1991-05-28 |
| CZ279046B6 (en) | 1994-12-15 |
| IL94867A0 (en) | 1991-04-15 |
| FI95870C (fi) | 1996-04-10 |
| KR0165676B1 (ko) | 1999-01-15 |
| DK0407804T3 (da) | 1994-02-07 |
| CS349090A3 (en) | 1992-01-15 |
| AU624006B2 (en) | 1992-05-28 |
| SK278731B6 (sk) | 1998-02-04 |
| DE3923270C2 (fi) | 1991-07-25 |
| KR910002439A (ko) | 1991-02-25 |
| HU208073B (en) | 1993-08-30 |
| DE59003304D1 (de) | 1993-12-09 |
| AU5787990A (en) | 1991-01-17 |
| ES2059899T3 (es) | 1994-11-16 |
| FI95870B (fi) | 1995-12-29 |
| HU904199D0 (en) | 1990-12-28 |
| DE3923270A1 (de) | 1991-01-17 |
| EP0407804A1 (de) | 1991-01-16 |
| EP0407804B1 (de) | 1993-11-03 |
| JPH03128319A (ja) | 1991-05-31 |
| US5296237A (en) | 1994-03-22 |
| DD296417A5 (de) | 1991-12-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5296237A (en) | Water-soluble pharmaceutical metallocene-complex composition | |
| DE60132108T2 (de) | Gefriergetrocknetes pantoprazol-präparat und pantoprazol-injektion | |
| KR100810066B1 (ko) | 투명 수용성 마취제 조성물 | |
| EP0673245B1 (fr) | Composition pharmaceutique effervescente contenant de l'ibuprofene et son procede de preparation | |
| AU2002216042A1 (en) | Freeze-dried pantoprazole preparation and pantoprazole injection | |
| CA2309326A1 (en) | Pharmaceutical compositions containing cyclodextrins and taxoids | |
| US4866088A (en) | Preparation process for an aqueous pharmaceutical solution of an active principle constituted by an organic acid | |
| CA1160571A (en) | Antitumor compositions | |
| DK168655B1 (da) | Frysetørret parenteralt præparat indeholdende phenylquinolincarboxylsyrer | |
| GB1576731A (en) | Process for the preparation of sodium amoxycillin | |
| CA2021268A1 (en) | Water-soluble pharmaceutical metallocene-complex composition | |
| JPH0149693B2 (fi) | ||
| EP0318906B1 (en) | Lyophilized preparation of platinum compound | |
| US4425348A (en) | Antitumor compositions | |
| CA1292944C (en) | Preparation process for an aqueous pharmaceutical solution of an active principle constituted by an organic acid | |
| JP2018177649A (ja) | ボルテゾミブを含有する医薬組成物 | |
| GB2068729A (en) | Antitumour compositions | |
| IE45401B1 (en) | Process for the preparation of sodium amoxycillin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| RH | Patent void |