IL92124A - חלבונים רקומביננטיים ששונו כדי להכיל אחרי פוספורילציה שאינם מופיעים בטבע - Google Patents

חלבונים רקומביננטיים ששונו כדי להכיל אחרי פוספורילציה שאינם מופיעים בטבע

Info

Publication number
IL92124A
IL92124A IL9212489A IL9212489A IL92124A IL 92124 A IL92124 A IL 92124A IL 9212489 A IL9212489 A IL 9212489A IL 9212489 A IL9212489 A IL 9212489A IL 92124 A IL92124 A IL 92124A
Authority
IL
Israel
Prior art keywords
protein
ifn
phosphorylatable
amino acid
sequence
Prior art date
Application number
IL9212489A
Other languages
English (en)
Other versions
IL92124A0 (en
Original Assignee
Sidney Pestka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sidney Pestka filed Critical Sidney Pestka
Publication of IL92124A0 publication Critical patent/IL92124A0/xx
Publication of IL92124A publication Critical patent/IL92124A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL9212489A 1988-10-28 1989-10-26 חלבונים רקומביננטיים ששונו כדי להכיל אחרי פוספורילציה שאינם מופיעים בטבע IL92124A (he)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26427188A 1988-10-28 1988-10-28

Publications (2)

Publication Number Publication Date
IL92124A0 IL92124A0 (en) 1990-07-12
IL92124A true IL92124A (he) 1996-10-31

Family

ID=23005308

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9212489A IL92124A (he) 1988-10-28 1989-10-26 חלבונים רקומביננטיים ששונו כדי להכיל אחרי פוספורילציה שאינם מופיעים בטבע

Country Status (9)

Country Link
US (1) US6225455B1 (he)
EP (1) EP0372707B1 (he)
JP (2) JP3621948B2 (he)
AT (1) ATE135014T1 (he)
CA (1) CA2001719C (he)
DE (1) DE68925869T2 (he)
ES (1) ES2087869T3 (he)
GR (1) GR3020060T3 (he)
IL (1) IL92124A (he)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747131B1 (en) 1988-10-28 2004-06-08 Pestka Biomedical Laboratories, Inc. Phosphorylated fusion proteins
US5545723A (en) * 1994-03-15 1996-08-13 Biogen Inc. Muteins of IFN-β
US6800747B1 (en) * 1995-06-07 2004-10-05 Pestka Biomedical Laboratories, Inc. Nucleic acids encoding phosphorylated fusion proteins
US5969102A (en) 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
US8885913B2 (en) 1999-01-25 2014-11-11 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US8131053B2 (en) 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US7450229B2 (en) 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US8406498B2 (en) 1999-01-25 2013-03-26 Amnis Corporation Blood and cell analysis using an imaging flow cytometer
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
CA2410754A1 (en) * 2000-05-31 2001-12-06 Sidney Pestka Phosphorylated polypeptides and uses related thereto
US7129331B2 (en) 2000-05-31 2006-10-31 Pestka Biomedical Laboratories, Inc. Phosphorylated polypeptides and uses related thereto
DE60129719T2 (de) 2000-09-14 2008-06-05 The Mount Sinai School Of Medicine Screening-verfahren zum identifizieren von g-proteinen und anderen verbindungen,die die phosphodiesterase (pde)-aktivität beeinflussen
AU2001297843A1 (en) 2000-10-12 2002-12-23 Amnis Corporation Imaging and analyzing parameters of small moving objects such as cells
US7803982B2 (en) 2001-04-20 2010-09-28 The Mount Sinai School Of Medicine Of New York University T1R3 transgenic animals, cells and related methods
EP1800124B1 (en) 2004-03-16 2011-12-21 Amnis Corporation Image based quantitation of molecular translocation
US8953866B2 (en) 2004-03-16 2015-02-10 Amnis Corporation Method for imaging and differential analysis of cells
WO2005090945A1 (en) 2004-03-16 2005-09-29 Amnis Corporation Method for imaging and differential analysis of cells
WO2007067999A2 (en) 2005-12-09 2007-06-14 Amnis Corporation Extended depth of field imaging for high speed object analysis
US8001400B2 (en) * 2006-12-01 2011-08-16 Apple Inc. Power consumption management for functional preservation in a battery-powered electronic device
US8451524B2 (en) 2009-09-29 2013-05-28 Amnis Corporation Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile
US8817115B1 (en) 2010-05-05 2014-08-26 Amnis Corporation Spatial alignment of image data from a multichannel detector using a reference image

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7811630L (sv) 1977-11-17 1979-05-18 Welsh Nat School Med Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik
IT1167610B (it) 1982-01-19 1987-05-13 Cetus Corp Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US4591552A (en) 1982-09-29 1986-05-27 New York Blood Center, Inc. Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
US4739046A (en) 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
CA1338860C (en) * 1987-04-13 1997-01-21 Peter Parker Radiolabelling of proteins
US5001064A (en) 1988-06-20 1991-03-19 Washington University Phosphatidylinositol 4-kinase

Also Published As

Publication number Publication date
CA2001719C (en) 2002-01-15
US6225455B1 (en) 2001-05-01
ES2087869T3 (es) 1996-08-01
CA2001719A1 (en) 1990-04-28
DE68925869T2 (de) 1996-11-14
EP0372707A2 (en) 1990-06-13
EP0372707A3 (en) 1991-09-11
JP3621948B2 (ja) 2005-02-23
ATE135014T1 (de) 1996-03-15
GR3020060T3 (en) 1996-08-31
EP0372707B1 (en) 1996-03-06
DE68925869D1 (de) 1996-04-11
JPH02288900A (ja) 1990-11-28
JP2004089184A (ja) 2004-03-25
IL92124A0 (en) 1990-07-12

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