IL90107A0 - Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one - Google Patents

Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one

Info

Publication number
IL90107A0
IL90107A0 IL90107A IL9010789A IL90107A0 IL 90107 A0 IL90107 A0 IL 90107A0 IL 90107 A IL90107 A IL 90107A IL 9010789 A IL9010789 A IL 9010789A IL 90107 A0 IL90107 A0 IL 90107A0
Authority
IL
Israel
Prior art keywords
transhexahydro
quinolizin
methano
hydroxy
carboxylic acid
Prior art date
Application number
IL90107A
Other languages
English (en)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL90107A0 publication Critical patent/IL90107A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL90107A 1988-04-29 1989-04-27 Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one IL90107A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18823288A 1988-04-29 1988-04-29

Publications (1)

Publication Number Publication Date
IL90107A0 true IL90107A0 (en) 1989-12-15

Family

ID=22692288

Family Applications (1)

Application Number Title Priority Date Filing Date
IL90107A IL90107A0 (en) 1988-04-29 1989-04-27 Process for preparing indole-3-carboxylic acid esters of transhexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one

Country Status (7)

Country Link
EP (1) EP0339669A1 (ja)
JP (1) JPH01313477A (ja)
KR (1) KR890016044A (ja)
DK (1) DK209289A (ja)
HU (1) HU201754B (ja)
IL (1) IL90107A0 (ja)
ZA (1) ZA893008B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1819705A1 (de) * 2004-11-25 2007-08-22 Cilag Ltd. Verfahren zur herstellung von estern von hexahydro-8-hydroxy-2,6-methano-2h-chinolizin-3(4h)-on
EP1904492B1 (en) * 2005-07-06 2008-10-15 Inke, S.A. Method for obtaining the pharmaceutically active compound dolasetron, synthesis intermediates thereof and methods for obtaining them
ES2264901B1 (es) 2005-07-06 2007-12-01 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo, sus intermedios de sintesis y procedimiento para la obtencion de los mismos.
US20080275241A1 (en) * 2005-12-23 2008-11-06 Tarur Venkatasubramanian Radha Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof
WO2007081890A2 (en) 2006-01-05 2007-07-19 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Production of dolasetron
US20090062546A1 (en) * 2007-07-20 2009-03-05 Janos Hajko Dolasetron trifluoroacetate, polymorphs of dolasetron trifluoroacetate and process for preparation thereof
ES2389261T3 (es) 2007-11-13 2012-10-24 Inke, S.A. Compuestos intermedios útiles para preparar dolasetrón
CN102180878B (zh) * 2010-07-02 2013-06-26 成都新恒创药业有限公司 一种多拉司琼异构体或其盐及其制备方法和其应用
CN109503580A (zh) * 2019-01-15 2019-03-22 南京恩泰医药科技有限公司 一种甲磺酸多拉司琼晶型及制备方法
CN113501820A (zh) * 2021-07-20 2021-10-15 南京恩泰医药科技有限公司 一种多拉司琼关键中间体hqo的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA878096B (en) * 1986-11-03 1988-04-26 Merrell Dow Pharmaceuticals Inc. Esters of hexahydro-8-hydroxy-2,6-methano-2h-quinolizin-3(4h)-one and related compounds

Also Published As

Publication number Publication date
JPH01313477A (ja) 1989-12-18
HUT50173A (en) 1989-12-28
KR890016044A (ko) 1989-11-28
HU201754B (en) 1990-12-28
DK209289D0 (da) 1989-04-28
ZA893008B (en) 1989-12-27
DK209289A (da) 1989-10-30
EP0339669A1 (en) 1989-11-02

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Legal Events

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Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.