IL86418A0 - Cell lines expressing an indicator gene product under the regulations of a specific regulatory protein and their use for screening agents which inhibit the function of said regulatory protein - Google Patents

Cell lines expressing an indicator gene product under the regulations of a specific regulatory protein and their use for screening agents which inhibit the function of said regulatory protein

Info

Publication number
IL86418A0
IL86418A0 IL86418A IL8641888A IL86418A0 IL 86418 A0 IL86418 A0 IL 86418A0 IL 86418 A IL86418 A IL 86418A IL 8641888 A IL8641888 A IL 8641888A IL 86418 A0 IL86418 A0 IL 86418A0
Authority
IL
Israel
Prior art keywords
regulatory protein
regulations
inhibit
cell lines
function
Prior art date
Application number
IL86418A
Other languages
English (en)
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of IL86418A0 publication Critical patent/IL86418A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL86418A 1987-05-19 1988-05-18 Cell lines expressing an indicator gene product under the regulations of a specific regulatory protein and their use for screening agents which inhibit the function of said regulatory protein IL86418A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5197087A 1987-05-19 1987-05-19

Publications (1)

Publication Number Publication Date
IL86418A0 true IL86418A0 (en) 1988-11-15

Family

ID=21974555

Family Applications (1)

Application Number Title Priority Date Filing Date
IL86418A IL86418A0 (en) 1987-05-19 1988-05-18 Cell lines expressing an indicator gene product under the regulations of a specific regulatory protein and their use for screening agents which inhibit the function of said regulatory protein

Country Status (8)

Country Link
EP (1) EP0291893A1 (xx)
JP (1) JPS63309185A (xx)
KR (1) KR910004101B1 (xx)
AU (1) AU1632788A (xx)
DK (1) DK271688A (xx)
IL (1) IL86418A0 (xx)
NZ (1) NZ224667A (xx)
ZA (1) ZA883529B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0391911A4 (en) * 1987-09-21 1990-12-05 Amrad Corporation Limited Regulation of expression of gm-csf gene
DE68929343T2 (de) * 1988-02-16 2002-09-12 Greatbatch Gen-Aid, Ltd. Modifizierte Zellen mit Resistenz gegen Retroviralinfektionen
US5070012A (en) * 1988-03-30 1991-12-03 The Board Of Trustees Of The Leland Stanford Junior University Monitoring of cells and trans-activating transcription elements
AU3756789A (en) * 1988-06-16 1990-01-12 St. Louis University Antagonists of viral transactivating proteins
US5278042A (en) * 1989-02-06 1994-01-11 The United States Of America As Represented By The Department Of Health & Human Services Method for detecting inhibitors of tat protein
US5871958A (en) * 1989-05-25 1999-02-16 Duke University Mutant rev genes encoding transdominant repressors of HIV replication
US6251675B1 (en) 1989-05-25 2001-06-26 Duke University Methods utilizing mutant rev genes encoding transdominant repressors of HIV replication
FR2651005B1 (fr) * 1989-08-17 1992-01-03 Pasteur Institut Lignees de cellules infectables par un retrovirus et contenant un marqueur activable a l'occasion de l'infection
GB9003010D0 (en) * 1990-02-09 1990-04-04 Glaxo Group Ltd Gene expression in yeast cells
IT1241123B (it) * 1990-04-19 1993-12-29 Consiglio Nazionale Ricerche Cellule umane per l'elevata espressione di geni inseriti in dna ricombinanti episomiali,loro preparazione e loro impiego
DE4036784A1 (de) * 1990-11-17 1992-05-21 Behringwerke Ag Antivirale aktivitaet des vom adeno-assoziierten virus typ 2 codierten rep-gens
GB9114437D0 (en) * 1991-07-03 1991-08-21 Health Lab Service Board Recombinant adenoviruses and the use thereof for detecting the presence in eukaryotic cells of the expression products of specific genes
ATE192499T1 (de) * 1992-03-13 2000-05-15 Monsanto Co Herstellung rekombinanter proteine unter verwendung von herpes-virus-promotoren und vp16- transaktivatoren
ATE447621T1 (de) * 1996-01-29 2009-11-15 Monogram Biosciences Inc Verfahren zur bestimmung antiviraler wirkstoff suszeptibilität und resistenz sowie antivirales wirkstoff-screening
US6242187B1 (en) 1996-01-29 2001-06-05 Virologic, Inc. Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening
US5928888A (en) * 1996-09-26 1999-07-27 Aurora Biosciences Corporation Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
EP1012334A4 (en) * 1997-07-30 2004-12-29 Virologic Inc COMPOSITIONS AND METHODS FOR DETERMINING SENSITIVITY AND RESISTANCE TO ANTIVIRAL DRUGS, AND SCREENING FOR ANTIVIRAL DRUGS
EP1002089A1 (en) * 1997-08-15 2000-05-24 E.I. Du Pont De Nemours And Company Plant genes encoding dr1 and drap1, a global repressor complex of transcription

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4738922A (en) * 1984-05-25 1988-04-19 Dana Farber Cancer Institute Trans-acting transcriptional factors

Also Published As

Publication number Publication date
NZ224667A (en) 1990-03-27
EP0291893A1 (en) 1988-11-23
DK271688A (da) 1988-11-20
KR910004101B1 (ko) 1991-06-22
DK271688D0 (da) 1988-05-18
ZA883529B (en) 1990-01-31
AU1632788A (en) 1988-11-24
JPS63309185A (ja) 1988-12-16
KR880014097A (ko) 1988-12-22

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