IL83586A - Acylated aminoalkyl and hydroxyalkyl substituted spirocondensed hexahydroarylquinolizines and peripheral alpha2 adrenoceptor antagonist pharmaceutical compositions containing them - Google Patents

Acylated aminoalkyl and hydroxyalkyl substituted spirocondensed hexahydroarylquinolizines and peripheral alpha2 adrenoceptor antagonist pharmaceutical compositions containing them

Info

Publication number
IL83586A
IL83586A IL83586A IL8358687A IL83586A IL 83586 A IL83586 A IL 83586A IL 83586 A IL83586 A IL 83586A IL 8358687 A IL8358687 A IL 8358687A IL 83586 A IL83586 A IL 83586A
Authority
IL
Israel
Prior art keywords
hexahydroarylquinolizines
spirocondensed
peripheral
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL83586A
Other versions
IL83586A0 (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IL83586A0 publication Critical patent/IL83586A0/en
Publication of IL83586A publication Critical patent/IL83586A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Certain substituted hexahydroarylquinolizines and pharmaceutically acceptable salts thereof are peripherally selective alpha 2-adrenoceptor antagonists. The compounds are adapted to be employed for the treatment of certain pathological disorders such as hypertension, diabetes, disorders involving platelet aggregation and the like without side effects attributable to effect on the central nervous system.
IL83586A 1986-08-28 1987-08-19 Acylated aminoalkyl and hydroxyalkyl substituted spirocondensed hexahydroarylquinolizines and peripheral alpha2 adrenoceptor antagonist pharmaceutical compositions containing them IL83586A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90148586A 1986-08-28 1986-08-28

Publications (2)

Publication Number Publication Date
IL83586A0 IL83586A0 (en) 1988-01-31
IL83586A true IL83586A (en) 1991-12-15

Family

ID=25414273

Family Applications (1)

Application Number Title Priority Date Filing Date
IL83586A IL83586A (en) 1986-08-28 1987-08-19 Acylated aminoalkyl and hydroxyalkyl substituted spirocondensed hexahydroarylquinolizines and peripheral alpha2 adrenoceptor antagonist pharmaceutical compositions containing them

Country Status (14)

Country Link
EP (1) EP0259092B1 (en)
JP (1) JP2582799B2 (en)
KR (1) KR880002869A (en)
AT (1) ATE78482T1 (en)
AU (1) AU597412B2 (en)
CA (1) CA1288435C (en)
DE (1) DE3780542T2 (en)
DK (1) DK447387A (en)
ES (1) ES2044944T3 (en)
GR (1) GR3005537T3 (en)
IL (1) IL83586A (en)
NZ (1) NZ221485A (en)
PT (1) PT85593B (en)
ZA (1) ZA876400B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4942235A (en) * 1989-03-16 1990-07-17 Merck & Co., Inc. Process for certain (2R-trans)hexahydroaroquinolizines
US5229387A (en) * 1991-09-20 1993-07-20 Syntex (U.S.A.) Inc. Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo [2,3-e]quinolizine derivatives
FR2744451B1 (en) * 1996-02-01 1998-04-24 Pf Medicament NOVEL IMIDAZOLIDINONES, PYRIMIDINONES, AND 1,3-DIAZEPIN-2 -ONES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS
US6141745A (en) * 1998-04-30 2000-10-31 Advanced Micro Devices, Inc. Functional bit identifying a prefix byte via a particular state regardless of type of instruction
FI126838B (en) 2014-12-16 2017-06-15 Vetcare Oy Process for preparation of spirocyclic substituted benzofuroquinolizines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1435573A (en) * 1973-05-25 1976-05-12 Wyeth John & Brother Ltd Indoloquinolizines
GB2106909B (en) * 1981-10-07 1984-09-19 Wyeth John & Brother Ltd Benzoquinolizines
IE57014B1 (en) * 1983-03-25 1992-03-11 Wyeth John & Brother Ltd Benzoquinolizines
GR850211B (en) * 1984-02-02 1985-05-24 Merck & Co Inc
NZ216283A (en) * 1985-06-03 1989-10-27 Merck & Co Inc Hexahydro arylquinolizine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
PT85593B (en) 1990-05-31
AU7720587A (en) 1988-03-03
ZA876400B (en) 1988-02-25
EP0259092B1 (en) 1992-07-22
DE3780542D1 (en) 1992-08-27
DK447387D0 (en) 1987-08-27
JP2582799B2 (en) 1997-02-19
DK447387A (en) 1988-02-29
EP0259092A1 (en) 1988-03-09
NZ221485A (en) 1991-04-26
IL83586A0 (en) 1988-01-31
JPS63139183A (en) 1988-06-10
GR3005537T3 (en) 1993-06-07
AU597412B2 (en) 1990-05-31
KR880002869A (en) 1988-05-12
CA1288435C (en) 1991-09-03
DE3780542T2 (en) 1993-01-07
ES2044944T3 (en) 1994-01-16
PT85593A (en) 1987-09-01
ATE78482T1 (en) 1992-08-15

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Legal Events

Date Code Title Description
RH Patent void