IE802600L - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number
IE802600L
IE802600L IE802600A IE260080A IE802600L IE 802600 L IE802600 L IE 802600L IE 802600 A IE802600 A IE 802600A IE 260080 A IE260080 A IE 260080A IE 802600 L IE802600 L IE 802600L
Authority
IE
Ireland
Prior art keywords
piperidinyl
salts
ethyl
useful
disorders
Prior art date
Application number
IE802600A
Other versions
IE52591B1 (en
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of IE802600L publication Critical patent/IE802600L/en
Publication of IE52591B1 publication Critical patent/IE52591B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Indole derivs. of formula (I), within the general scope of the parent patent, and their acid addn. salts are new. (X is methyl and Y is 3-piperidinyl (cpd. Ia) or 1-propyl-3-piperidinyl (Ib); or X is H and Y is 1-ethyl-3-piperidinyl (Ic) or 1-ethyl-1,2,5,6-tetrahydro-3-pyridinyl (Id)). Specificed salts are the hydrochloride of (Ia); the oxalate of (Ib); the neutral fumarate of (Ic) and the phosphate of (Id). (I) are useful as dopaminergic stimulants; some also have adrenergic and serotoninergic activities. They are useful for treating extrapyramidal neurological disorders (e.g. Parkinson's disease); excessive secretion of prolactin (e.g. hypogonadism); cerebral senescence; vertebrobasal insufficiency; arterial hypertension; peripheral circulator disorders; and arteriopathy of the legs. All cpds. were tolerated at doses of 60 mg or more per kg, intraperitoneally in mice, without any deaths. [FR2492824A2]
IE2600/80A 1980-10-24 1980-12-11 New indole derivatives,process for preparing them,and pharmaceutical compositions containing them IE52591B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8022819A FR2492824A2 (en) 1980-10-24 1980-10-24 4-Piperidinyl indole derivs. - with dopaminergic activity e.g. for treating Parkinsons disease and excessive prolactin secretion

Publications (2)

Publication Number Publication Date
IE802600L true IE802600L (en) 1982-04-24
IE52591B1 IE52591B1 (en) 1987-12-23

Family

ID=9247299

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2600/80A IE52591B1 (en) 1980-10-24 1980-12-11 New indole derivatives,process for preparing them,and pharmaceutical compositions containing them

Country Status (4)

Country Link
JP (1) JPS5772980A (en)
ES (1) ES497612A0 (en)
FR (1) FR2492824A2 (en)
IE (1) IE52591B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2391211A2 (en) * 1977-05-18 1978-12-15 Roussel Uclaf Antihypertensive 2-indolyl:piperidinyl-1-benzo-dioxanyl ethanol cpds. - which are prepd. from indolyl:piperidine cpd. and oxiranyl benzodioxan
FR2458549A1 (en) * 1979-06-12 1981-01-02 Roussel Uclaf NOVEL INDOLE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS

Also Published As

Publication number Publication date
IE52591B1 (en) 1987-12-23
JPS5772980A (en) 1982-05-07
ES8204730A2 (en) 1982-05-01
ES497612A0 (en) 1982-05-01
FR2492824A2 (en) 1982-04-30
FR2492824B2 (en) 1983-01-14

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