IL82717A - Peptides that inhibit von willebrand factor binding to platelets,heparin and collagen - Google Patents

Peptides that inhibit von willebrand factor binding to platelets,heparin and collagen

Info

Publication number
IL82717A
IL82717A IL82717A IL8271787A IL82717A IL 82717 A IL82717 A IL 82717A IL 82717 A IL82717 A IL 82717A IL 8271787 A IL8271787 A IL 8271787A IL 82717 A IL82717 A IL 82717A
Authority
IL
Israel
Prior art keywords
peptides
platelets
heparin
collagen
von willebrand
Prior art date
Application number
IL82717A
Other languages
English (en)
Other versions
IL82717A0 (en
Inventor
Theodore S Zimmerman
Yoshihiro Fujimura
Richard A Houghten
Zaverio M Ruggeri
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of IL82717A0 publication Critical patent/IL82717A0/xx
Publication of IL82717A publication Critical patent/IL82717A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL82717A 1986-05-30 1987-05-29 Peptides that inhibit von willebrand factor binding to platelets,heparin and collagen IL82717A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86918886A 1986-05-30 1986-05-30

Publications (2)

Publication Number Publication Date
IL82717A0 IL82717A0 (en) 1987-11-30
IL82717A true IL82717A (en) 1992-03-29

Family

ID=25353087

Family Applications (1)

Application Number Title Priority Date Filing Date
IL82717A IL82717A (en) 1986-05-30 1987-05-29 Peptides that inhibit von willebrand factor binding to platelets,heparin and collagen

Country Status (9)

Country Link
EP (1) EP0255206B1 (ja)
JP (2) JP2742925B2 (ja)
AT (1) ATE120206T1 (ja)
AU (1) AU617981B2 (ja)
CA (1) CA1340187C (ja)
DE (1) DE3751179T2 (ja)
ES (1) ES2070116T3 (ja)
IL (1) IL82717A (ja)
NZ (1) NZ220526A (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5900476A (en) * 1986-05-30 1999-05-04 The Scripps Research Institute Therapeutic domains of van Willebrand factor
ZA884504B (en) * 1987-06-29 1989-03-29 Merrell Dow Pharma Immunosuppressant peptides
EP0426857A4 (en) * 1989-02-08 1991-10-16 Kuraray Co. Ltd. Peptide and adsorbent comprising same immobilized on carrier
US5332726A (en) * 1989-09-29 1994-07-26 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antithrombotic peptides and pseudopeptides
NZ237244A (en) * 1990-03-02 1992-10-28 Bio Technology General Corp Cloning and production of human von willebrand factor analogues and compositions thereof
US6008193A (en) * 1990-03-02 1999-12-28 Bio-Technology General Corp. Methods of using human von Willebrand factor GPIb binding domain polypeptides
US5849536A (en) * 1990-03-02 1998-12-15 Bio-Technology General Corp. Cloning and production of human von willebrand factor GPIb binding domain polypeptides and methods of using same
US5064814A (en) * 1990-04-05 1991-11-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptide and pseudopeptide derivatives
US5597799A (en) * 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
US5278144A (en) * 1990-09-04 1994-01-11 Cor Therapeutics, Inc. Antithrombosis agents
US5321127A (en) * 1991-03-18 1994-06-14 Brigham And Women's Hospital Antiplatelet and antithrombotic activity of platelet glycoprotein Ib receptor fragments
MX9203011A (es) * 1991-06-20 1993-08-01 Rhone Poulenc Rorer Int Procedimiento para preparar una solucion acuosa de fragmento de factor de von willebrand alterado con cisteina y solucion terapeutica fundida mediante el mismo
US5847086A (en) * 1991-06-20 1998-12-08 Centeon L.L.C. Therapeutic fragments of von Willebrand factor
AU2865692A (en) * 1991-10-04 1993-05-03 Virginia Commonwealth University Von willebrand factor-specific heparin fractions
FR2686901A1 (fr) * 1992-01-31 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
JPH08512291A (ja) * 1993-04-23 1996-12-24 バイオ−テクノロジー・ジェネラル・コーポレーション 血栓溶解の増強方法
JP3742429B2 (ja) * 1993-07-01 2006-02-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング コラーゲン刺激血小板凝集の阻害剤
US6387663B1 (en) * 1998-07-31 2002-05-14 University Of Southern California Targeting pharmaceutical agents to injured tissues
GB0031448D0 (en) 2000-12-22 2001-02-07 Leuven K U Res & Dev Inhibition of the vWF-collagen interaction by anti-human vWF monoclonal antibody (82D6A3) results in abolition of in vivo arterial platelet thrombus formation
US7691839B2 (en) 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20080015145A1 (en) 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
CA2600220C (en) * 2006-09-07 2014-12-09 Canadian Blood Services Surface cross-linked lipidic particles, methods of production and uses therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666884A (en) * 1984-04-10 1987-05-19 New England Deaconess Hospital Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
IL88309A0 (en) * 1987-11-17 1989-06-30 Scripps Clinic Res Peptides for use in the purification of factor viii

Also Published As

Publication number Publication date
CA1340187C (en) 1998-12-15
JP2742925B2 (ja) 1998-04-22
EP0255206B1 (en) 1995-03-22
DE3751179D1 (de) 1995-04-27
EP0255206A2 (en) 1988-02-03
AU617981B2 (en) 1991-12-12
ES2070116T3 (es) 1995-06-01
JPS63152396A (ja) 1988-06-24
AU7371587A (en) 1987-12-03
NZ220526A (en) 1989-08-29
EP0255206A3 (en) 1989-11-23
DE3751179T2 (de) 1995-07-27
ATE120206T1 (de) 1995-04-15
JP2939557B2 (ja) 1999-08-25
JPH08337596A (ja) 1996-12-24
IL82717A0 (en) 1987-11-30

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