IL81569A - 2-substituted quinoline dioic acids and pharmaceutical compositions containing them - Google Patents
2-substituted quinoline dioic acids and pharmaceutical compositions containing themInfo
- Publication number
- IL81569A IL81569A IL81569A IL8156987A IL81569A IL 81569 A IL81569 A IL 81569A IL 81569 A IL81569 A IL 81569A IL 8156987 A IL8156987 A IL 8156987A IL 81569 A IL81569 A IL 81569A
- Authority
- IL
- Israel
- Prior art keywords
- substd
- opt
- alkyl
- benzyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA501932 | 1986-02-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL81569A0 IL81569A0 (en) | 1987-09-16 |
IL81569A true IL81569A (en) | 1991-11-21 |
Family
ID=4132478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL81569A IL81569A (en) | 1986-02-14 | 1987-02-13 | 2-substituted quinoline dioic acids and pharmaceutical compositions containing them |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0233763B1 (ko) |
JP (1) | JPH0686432B2 (ko) |
KR (1) | KR870007920A (ko) |
AT (1) | ATE60584T1 (ko) |
AU (1) | AU595286B2 (ko) |
DE (1) | DE3767730D1 (ko) |
DK (1) | DK168534B1 (ko) |
ES (1) | ES2031498T3 (ko) |
GR (1) | GR3001474T3 (ko) |
IE (1) | IE59889B1 (ko) |
IL (1) | IL81569A (ko) |
NZ (1) | NZ219249A (ko) |
PT (1) | PT84287B (ko) |
ZA (1) | ZA871064B (ko) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0271287A3 (en) * | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Quinoline dioic acids and amides |
US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920130A (en) * | 1987-11-02 | 1990-04-24 | Rorer Pharamceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US4920131A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
US5204358A (en) * | 1987-11-25 | 1993-04-20 | Merck Frosst Canada, Inc. | Hetaryl styryl quinolines as leukotriene inhibitors |
US5104882A (en) * | 1987-11-25 | 1992-04-14 | Merck Frosst Canada, Inc. | Diarylstrylquinoline diacids and pharmaceutical compositions thereof |
EP0318093A3 (en) * | 1987-11-25 | 1990-12-05 | Merck Frosst Canada Inc. | Diarylquinoline diacids and their use as medicaments |
CA1322004C (en) * | 1987-11-25 | 1993-09-07 | Merck Frosst Canada Incorporated | Pyridyl styrene dialkanoic acids |
AU617386B2 (en) * | 1987-12-01 | 1991-11-28 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Substituted quinolines |
GB8728051D0 (en) * | 1987-12-01 | 1988-01-06 | Leo Pharm Prod Ltd | Chemical compounds |
US4883878A (en) * | 1988-02-08 | 1989-11-28 | Merck & Co. Inc. | Process for unsymmetrical dithioacetals and dithioketals |
EP0349062A1 (en) * | 1988-06-27 | 1990-01-03 | Merck Frosst Canada Inc. | Quinoline ether alkanoic acid |
US5070022A (en) * | 1988-12-22 | 1991-12-03 | Merck & Co., Inc. | Enzymic process for preparing leukotriene antagonists |
NZ233752A (en) * | 1989-05-24 | 1993-05-26 | Merck Frosst Canada Inc | Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof |
US4996214A (en) * | 1990-06-28 | 1991-02-26 | Smithkline Beecham Corporation | Quinolinyl substituted phenyl/thioalkanoic acid substituted propionic acids and leucotriene antagonist use thereof |
US5428033A (en) * | 1990-10-12 | 1995-06-27 | Merck Frosst Canada, Inc. | Saturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5266568A (en) * | 1990-10-12 | 1993-11-30 | Merck Frosst Canada, Inc. | Hydroxyalkylquinoline ether acids as leukotriene antagonists |
ATE128969T1 (de) * | 1990-10-12 | 1995-10-15 | Merck Frosst Canada Inc | Hydroxyalkylchinolin äther säure als leukotrien- antagoniste. |
DK0480717T3 (da) * | 1990-10-12 | 1999-02-08 | Merck Frosst Canada Inc | Umættede hydroxyalkylquinolinsyrer som leukotrienantagonister |
US5856322A (en) * | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
US5212180A (en) * | 1991-02-21 | 1993-05-18 | Merck Frosst Canada, Inc. | Quinoline-containing ketoacids as leukotriene antagonists |
IE920499A1 (en) * | 1991-02-21 | 1992-08-26 | Merck Frosst Canada Inc | Quinoline-containing ketoacids as leukotriene antagonists |
US5276044A (en) * | 1991-08-14 | 1994-01-04 | Allergan, Inc. | Leukotriene receptor antagonist and antihistamine complex pharmaceutical compositions |
US5270324A (en) * | 1992-04-10 | 1993-12-14 | Merck Frosst Canada, Inc. | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
AU4413893A (en) * | 1992-06-22 | 1994-01-24 | Merck Frosst Canada Inc. | Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes |
US5964261A (en) * | 1996-05-29 | 1999-10-12 | Baxter International Inc. | Implantation assembly |
US20030216571A1 (en) * | 1999-12-28 | 2003-11-20 | Yoshiaki Kuroki | Tricyclic compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
US4625034A (en) * | 1985-02-04 | 1986-11-25 | Usv Pharmaceutical Corp. | 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives |
ES8801209A1 (es) * | 1985-06-18 | 1988-01-01 | Merck Frosst Canada Inc | Un procedimiento para la preparacion de quinolinas 2-sustituidas. |
-
1987
- 1987-02-09 IE IE33487A patent/IE59889B1/en not_active IP Right Cessation
- 1987-02-12 AU AU68717/87A patent/AU595286B2/en not_active Ceased
- 1987-02-12 NZ NZ219249A patent/NZ219249A/xx unknown
- 1987-02-13 PT PT84287A patent/PT84287B/pt not_active IP Right Cessation
- 1987-02-13 AT AT87301256T patent/ATE60584T1/de not_active IP Right Cessation
- 1987-02-13 KR KR870001190A patent/KR870007920A/ko not_active Application Discontinuation
- 1987-02-13 DE DE8787301256T patent/DE3767730D1/de not_active Expired - Lifetime
- 1987-02-13 EP EP87301256A patent/EP0233763B1/en not_active Expired - Lifetime
- 1987-02-13 ZA ZA871064A patent/ZA871064B/xx unknown
- 1987-02-13 ES ES198787301256T patent/ES2031498T3/es not_active Expired - Lifetime
- 1987-02-13 DK DK072287A patent/DK168534B1/da not_active IP Right Cessation
- 1987-02-13 IL IL81569A patent/IL81569A/xx not_active IP Right Cessation
- 1987-02-14 JP JP62032282A patent/JPH0686432B2/ja not_active Expired - Fee Related
-
1991
- 1991-02-13 GR GR91400190T patent/GR3001474T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPS62258363A (ja) | 1987-11-10 |
PT84287B (pt) | 1989-09-14 |
ZA871064B (en) | 1987-10-28 |
ES2031498T3 (es) | 1992-12-16 |
NZ219249A (en) | 1990-07-26 |
DK72287A (da) | 1987-08-15 |
AU595286B2 (en) | 1990-03-29 |
AU6871787A (en) | 1987-08-20 |
EP0233763A3 (en) | 1988-10-19 |
IE870334L (en) | 1987-08-14 |
EP0233763A2 (en) | 1987-08-26 |
DE3767730D1 (de) | 1991-03-07 |
GR3001474T3 (en) | 1992-10-08 |
JPH0686432B2 (ja) | 1994-11-02 |
ATE60584T1 (de) | 1991-02-15 |
DK168534B1 (da) | 1994-04-18 |
IL81569A0 (en) | 1987-09-16 |
EP0233763B1 (en) | 1991-01-30 |
IE59889B1 (en) | 1994-04-20 |
KR870007920A (ko) | 1987-09-22 |
DK72287D0 (da) | 1987-02-13 |
PT84287A (en) | 1987-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL81569A (en) | 2-substituted quinoline dioic acids and pharmaceutical compositions containing them | |
DK0382450T3 (da) | Fremgangsmåde til fremstilling af mono- eller dicarboxylsyrematerialer substituerede med langkædet hydrocarbyl | |
AT348681B (de) | Reinigungsmittel fuer zahnprothesen | |
DK207175A (da) | Fremgangsmade til fremstilling af cephalosporiner med alfa-acylaminoeddikesyresidekede | |
IT1032781B (it) | Procedimento per la costruzione di denti artificiali | |
SE392526B (sv) | Automatisk anordoing for indikering av sprickor i svetsfogar | |
BE834055A (fr) | Raccord adaptateur perfectionne pour catheter | |
FR2340717A1 (fr) | Procede pour remineraliser et immuniser l'email dentaire | |
IT8324409A0 (it) | Sali di metallo alcalino di acidi procedimento per la preparazione di polietossicarbossilici. | |
BE837505A (fr) | Procede pour la sequestration de l'oxygene dissous dans l'eau et compositions utilisables a cet effet | |
BE828957A (fr) | Joint perfectionne pour turbo-machines | |
IT1036231B (it) | Procedimento ed apparecchio per l introduzione di additivi in una forma di colata | |
FR2279509A1 (fr) | Metal d'apport pour soudures | |
IT1007331B (it) | Chiusura meccanica per fessure di giunzioni | |
IT1048158B (it) | Procedimento per preparare anidridin carbossiliche di amminoacidi | |
IT942592B (it) | Procedimento ed apparecchio per determinare la posizione di una conduttura subacquea durante il suo interramento | |
IT1003700B (it) | Giunto per unire elementi girevoli | |
IT986994B (it) | Procedimento per la preparazione di sali di addizione con acidi inorganici della urea | |
IT1025674B (it) | Procedimento per determinare il tenore di ossido in bagni fusi salini | |
IT8148730A0 (it) | Composizioni farmaceutiche antibroncospastiche idrosolubili costituite da sali della teofillina con aminoacidi basici | |
GB1304174A (ko) | ||
FR2280475A1 (fr) | Metal d'apport pour soudure | |
BE834823A (fr) | Raccord de filtres en particulier pour installations de traitement d'eau | |
IT1001989B (it) | Procedimento per la preparazione di lattici stabili ai sali e lattici cosi prodotti | |
IT1040561B (it) | Procedimento ed apparecchiatura per la depurazione spinta di soluzioni acquose di sali metallici |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
HS | Change of address for service | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |