IL76400A - 1,4-dihydro-2-6-dimethyl-4-(3-nitrophenyl)-3-alkoxycarbonyl-5-(2-(2-(1,2,3,4-(tetrahydro-isoquinolinyl)ethoxycarbonyl pyridine derivatives and pharmaceutical compositions containing them - Google Patents
1,4-dihydro-2-6-dimethyl-4-(3-nitrophenyl)-3-alkoxycarbonyl-5-(2-(2-(1,2,3,4-(tetrahydro-isoquinolinyl)ethoxycarbonyl pyridine derivatives and pharmaceutical compositions containing themInfo
- Publication number
- IL76400A IL76400A IL76400A IL7640085A IL76400A IL 76400 A IL76400 A IL 76400A IL 76400 A IL76400 A IL 76400A IL 7640085 A IL7640085 A IL 7640085A IL 76400 A IL76400 A IL 76400A
- Authority
- IL
- Israel
- Prior art keywords
- isoquinolinyl
- nitrophenyl
- alkoxycarbonyl
- tetrahydro
- dihydro
- Prior art date
Links
- -1 ethoxycarbonyl pyridine derivatives Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22898/84A IT1196272B (it) | 1984-09-28 | 1984-09-28 | Derivati di 1,4-diidropiridina e composizioni farmaceutiche che li contengono |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL76400A0 IL76400A0 (en) | 1986-01-31 |
| IL76400A true IL76400A (en) | 1988-11-15 |
Family
ID=11201669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL76400A IL76400A (en) | 1984-09-28 | 1985-09-15 | 1,4-dihydro-2-6-dimethyl-4-(3-nitrophenyl)-3-alkoxycarbonyl-5-(2-(2-(1,2,3,4-(tetrahydro-isoquinolinyl)ethoxycarbonyl pyridine derivatives and pharmaceutical compositions containing them |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4769374A (it) |
| EP (1) | EP0176053B1 (it) |
| JP (1) | JPS6187679A (it) |
| KR (1) | KR860002498A (it) |
| AT (1) | ATE40132T1 (it) |
| DE (2) | DE3567656D1 (it) |
| ES (1) | ES8606868A1 (it) |
| FI (1) | FI853584L (it) |
| IL (1) | IL76400A (it) |
| IT (1) | IT1196272B (it) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012123966A1 (en) | 2011-03-04 | 2012-09-20 | Arch Pharmalabs Limited | Process for the preparation of 4 -substituted -1, 4-dihydropyridines |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3996234A (en) * | 1972-04-18 | 1976-12-07 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters |
| JPS55301A (en) * | 1978-02-14 | 1980-01-05 | Yamanouchi Pharmaceut Co Ltd | 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its preparation |
| JPS57171968A (en) * | 1981-04-17 | 1982-10-22 | Kyowa Hakko Kogyo Co Ltd | 1,4-dihydropyridine derivative |
| WO1983003249A1 (en) * | 1982-03-17 | 1983-09-29 | Yoshitomi Pharmaceutical | 1,4-dihydropyridine-3,5-dicarboxylate derivatives |
| EP0094159B1 (en) * | 1982-05-10 | 1990-03-14 | Takeda Chemical Industries, Ltd. | Dihydropyridine derivatives, their production and use |
| US4419518A (en) * | 1982-07-26 | 1983-12-06 | Tokyo Tanabe Co. L.T.D. | 1,4-Dihydropyridine derivatives |
| US4652573A (en) * | 1985-03-14 | 1987-03-24 | Nelson Research & Development Co. | Calcium antagonist N-hetero ester 1,4-dihydropyridines |
-
1984
- 1984-09-28 IT IT22898/84A patent/IT1196272B/it active
-
1985
- 1985-09-15 IL IL76400A patent/IL76400A/xx unknown
- 1985-09-18 FI FI853584A patent/FI853584L/fi not_active Application Discontinuation
- 1985-09-20 AT AT85111946T patent/ATE40132T1/de not_active IP Right Cessation
- 1985-09-20 DE DE8585111946T patent/DE3567656D1/de not_active Expired
- 1985-09-20 EP EP85111946A patent/EP0176053B1/en not_active Expired
- 1985-09-20 DE DE198585111946T patent/DE176053T1/de active Pending
- 1985-09-23 US US06/779,243 patent/US4769374A/en not_active Expired - Fee Related
- 1985-09-26 ES ES547954A patent/ES8606868A1/es not_active Expired
- 1985-09-27 JP JP60214418A patent/JPS6187679A/ja active Pending
- 1985-09-28 KR KR1019850007194A patent/KR860002498A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FI853584L (fi) | 1986-03-29 |
| DE3567656D1 (en) | 1989-02-23 |
| IT8422898A0 (it) | 1984-09-28 |
| DE176053T1 (de) | 1986-09-04 |
| EP0176053B1 (en) | 1989-01-18 |
| FI853584A0 (fi) | 1985-09-18 |
| ES547954A0 (es) | 1986-05-16 |
| JPS6187679A (ja) | 1986-05-06 |
| US4769374A (en) | 1988-09-06 |
| ES8606868A1 (es) | 1986-05-16 |
| KR860002498A (ko) | 1986-04-26 |
| ATE40132T1 (de) | 1989-02-15 |
| IL76400A0 (en) | 1986-01-31 |
| IT1196272B (it) | 1988-11-16 |
| EP0176053A1 (en) | 1986-04-02 |
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