IL73826A0 - Improved method of preparing 2-fluoro-17beta-estradiol - Google Patents

Improved method of preparing 2-fluoro-17beta-estradiol

Info

Publication number
IL73826A0
IL73826A0 IL73826A IL7382684A IL73826A0 IL 73826 A0 IL73826 A0 IL 73826A0 IL 73826 A IL73826 A IL 73826A IL 7382684 A IL7382684 A IL 7382684A IL 73826 A0 IL73826 A0 IL 73826A0
Authority
IL
Israel
Prior art keywords
17beta
estradiol
fluoro
preparing
improved method
Prior art date
Application number
IL73826A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL73826A0 publication Critical patent/IL73826A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
IL73826A 1983-12-22 1984-12-14 Improved method of preparing 2-fluoro-17beta-estradiol IL73826A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/564,595 US4522758A (en) 1983-12-22 1983-12-22 Method of preparing 2-fluoro-17β-estradiol

Publications (1)

Publication Number Publication Date
IL73826A0 true IL73826A0 (en) 1985-03-31

Family

ID=24255123

Family Applications (1)

Application Number Title Priority Date Filing Date
IL73826A IL73826A0 (en) 1983-12-22 1984-12-14 Improved method of preparing 2-fluoro-17beta-estradiol

Country Status (9)

Country Link
US (1) US4522758A (de)
EP (1) EP0147155A3 (de)
JP (1) JPS60226894A (de)
KR (1) KR860001284B1 (de)
CA (1) CA1213881A (de)
DK (1) DK606084A (de)
GR (1) GR82481B (de)
HU (1) HU192654B (de)
IL (1) IL73826A0 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668668A (en) * 1984-03-20 1987-05-26 Wayne State University Compositions inhibiting murine MXT ductal carcinoma
US4676932A (en) * 1984-04-09 1987-06-30 The University Of New Mexico Synthesis of 1-haloestradiols
US5504074A (en) * 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
US6908910B2 (en) * 1993-08-06 2005-06-21 The Children's Medical Center Corporation Estrogenic compounds as anti-mitotic agents
US20040214807A1 (en) * 1993-08-06 2004-10-28 D'amato Robert J. Estrogenic compounds as anti-mitotic agents
WO1997008187A1 (en) * 1995-08-30 1997-03-06 Eli Lilly And Company N-butylsulfonate esters of estrogens
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US20020002294A1 (en) * 1997-09-24 2002-01-03 D' Amato Robert J. Estrogenic compounds as antiangiogenic agents
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
DE69922684T2 (de) 1998-08-11 2005-10-06 Entremed, Inc. Verwendung von 2-methoxyestradiol als fungizide
US7087592B1 (en) * 1999-08-23 2006-08-08 Entre Med, Inc. Compositions comprising purified 2-methoxyestradiol and methods of producing same
US6995278B2 (en) * 2000-08-18 2006-02-07 Entre Med, Inc. Antiangiogenic agents
US20050192258A1 (en) * 2000-08-18 2005-09-01 Agoston Gregory E. Antiangiogenic agents
US7135581B2 (en) 2000-08-18 2006-11-14 Entremed, Inc. Antiangiogenic agents
US20030187076A1 (en) * 2002-01-30 2003-10-02 Agoston Gregory E. Non-steroidal analogs of 2-methoxyestradiol
EP1633367A2 (de) * 2003-05-28 2006-03-15 EntreMed, Inc. Antiangiogene mittel
EP1756139A4 (de) 2004-03-12 2009-07-29 Entremed Inc Antiangiogene mittel
US20070004689A1 (en) * 2004-03-12 2007-01-04 Agoston Gregory E Antiangiogenic agents
CA2587448A1 (en) * 2004-11-29 2006-06-01 Entremed, Inc. A method of administering anti-angiogenic agents and a method of treating disease using same
US20070185069A1 (en) * 2005-11-14 2007-08-09 Plum Stacy M Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
US20070176403A1 (en) * 2006-02-01 2007-08-02 Dennis Calderone Air adjustable seat
EP2001482B1 (de) * 2006-03-20 2016-08-24 CASI Pharmaceuticals, Inc. Krankheitsmodifizierende antiarthritische wirkung von 2-methoxyestradiol
US20080234243A1 (en) * 2007-01-31 2008-09-25 Lavallee Theresa M Method of treating amyloidosis mediated diseases
RU2418000C1 (ru) * 2009-11-26 2011-05-10 Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет 3-МЕТОКСИ-2-ФТОР-18-ЭТИЛ-8α-ГОНА-1,3,5( 10 )-ТРИЕНЫ, ОБЛАДАЮЩИЕ ОСТЕОПРОТЕКТОРНОЙ И ГИПОХОЛЕСТЕРИНЕМИЧЕСКОЙ АКТИВНОСТЬЮ
RU2436792C1 (ru) * 2010-05-27 2011-12-20 Федеральное государственное образовательное учреждение высшего профессионального образования Санкт-Петербургский государственный университет Метиловый эфир 16,16-диметил-2-фтор-d-гомо-8альфа-эстрона, обладающий гиполипидемической и кардиопротекторной активностью
US9446050B2 (en) 2011-10-24 2016-09-20 The Brigham And Women's Hospital, Inc. Method for treatment of mesothelioma

Also Published As

Publication number Publication date
EP0147155A3 (de) 1985-10-30
HU192654B (en) 1987-06-29
DK606084D0 (da) 1984-12-18
HUT36841A (en) 1985-10-28
US4522758A (en) 1985-06-11
EP0147155A2 (de) 1985-07-03
DK606084A (da) 1985-06-23
GR82481B (en) 1985-04-18
KR860001284B1 (ko) 1986-09-05
JPS60226894A (ja) 1985-11-12
CA1213881A (en) 1986-11-12
KR850004500A (ko) 1985-07-15

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