IL71960A - Fused tricyclic derivatives of naphthyridinone,pyrido(2,3-b)pyrazinone and quinolone and the corresponding thiones,their preparation and pharmaceutical compositions containing them - Google Patents
Fused tricyclic derivatives of naphthyridinone,pyrido(2,3-b)pyrazinone and quinolone and the corresponding thiones,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL71960A IL71960A IL71960A IL7196084A IL71960A IL 71960 A IL71960 A IL 71960A IL 71960 A IL71960 A IL 71960A IL 7196084 A IL7196084 A IL 7196084A IL 71960 A IL71960 A IL 71960A
- Authority
- IL
- Israel
- Prior art keywords
- naphthyridinone
- pyrazinone
- quinolone
- pyrido
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49958483A | 1983-05-31 | 1983-05-31 | |
US06/597,887 US4680298A (en) | 1983-05-31 | 1984-04-09 | Tricyclic anti-allergy and use as anti-inflammatory agents |
Publications (2)
Publication Number | Publication Date |
---|---|
IL71960A0 IL71960A0 (en) | 1984-09-30 |
IL71960A true IL71960A (en) | 1988-07-31 |
Family
ID=27053194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL71960A IL71960A (en) | 1983-05-31 | 1984-05-29 | Fused tricyclic derivatives of naphthyridinone,pyrido(2,3-b)pyrazinone and quinolone and the corresponding thiones,their preparation and pharmaceutical compositions containing them |
Country Status (14)
Country | Link |
---|---|
US (1) | US4680298A (xx) |
EP (1) | EP0127135B1 (xx) |
JP (1) | JPH0747590B2 (xx) |
AU (1) | AU559754B2 (xx) |
CA (1) | CA1251208A (xx) |
DE (1) | DE3483064D1 (xx) |
DK (1) | DK160557C (xx) |
GB (1) | GB2142013B (xx) |
GR (1) | GR81552B (xx) |
HK (1) | HK8092A (xx) |
IL (1) | IL71960A (xx) |
NZ (1) | NZ208310A (xx) |
PH (1) | PH22970A (xx) |
SG (1) | SG83890G (xx) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK127086A (da) * | 1985-03-25 | 1986-09-26 | Schering Corp | Substituerede 1,8-naphthyridoner, fremgangsmaader til deres fremstilling og farmaceutiske kompositioner, der indeholder disse forbindelser |
US4596809A (en) * | 1985-03-25 | 1986-06-24 | Schering Corporation | Substituted 1,8-naphthyridinones, useful as anti-allergic agents |
US4988705A (en) * | 1985-06-13 | 1991-01-29 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
IE60420B1 (en) * | 1985-06-13 | 1994-07-13 | Schering Corp | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
US4810708A (en) * | 1986-05-15 | 1989-03-07 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
US5126352A (en) * | 1985-06-13 | 1992-06-30 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
DE3669656D1 (de) * | 1985-06-18 | 1990-04-26 | Schering Corp | Azanaphthalene enthaltende arzneimittelzusammensetzungen. |
US4801589A (en) * | 1986-06-12 | 1989-01-31 | Schering Corporation | Method for suppressing the immune response |
US4882332A (en) * | 1986-10-20 | 1989-11-21 | Schering Corporation | Immune suppression method employing arly-substituted naphthyridine and pyridopyrazine derivatives |
IL82150A0 (en) * | 1986-04-11 | 1987-10-30 | Schering Corp | Aryl-substituted naphthyridine and pyridopyrazine derivatives and pharmaceutical compositions containing them |
US4760073A (en) * | 1986-04-11 | 1988-07-26 | Schering Corporation | Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents |
US5011860A (en) * | 1986-04-11 | 1991-04-30 | Schering Corporation | Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases |
US5037826A (en) * | 1986-10-15 | 1991-08-06 | Schering Corporation | 1-substituted naphthyridine and pyridopyrazine derivatives |
US5045542A (en) * | 1986-10-20 | 1991-09-03 | Schering Corporation | Immune suppression method employing aryl-substituted naphthyridine and pyridopyrazine derivatives |
CA1309658C (en) * | 1986-12-05 | 1992-11-03 | David J. Blythin | Pharmaceutical compositions for treatment of hyperproliferate skin disease |
US5350755A (en) * | 1986-12-05 | 1994-09-27 | Schering Corporation | Compounds and methods for treating hyperproliferative skin disease |
US4740511A (en) * | 1987-02-18 | 1988-04-26 | Schering Corporation | Method of treating hyperproliferative skin disease |
WO1989000561A1 (en) * | 1987-07-15 | 1989-01-26 | Schering Corporation | Fused benzazepines |
US4897487A (en) * | 1988-04-06 | 1990-01-30 | Schering Corporation | Process for preparing intermediates for pharmaceutically useful bicyclic compounds |
MX13270A (es) * | 1987-10-05 | 1993-06-01 | Pfizer | Procedimiento para la preparacion de derivados de 4-aminopiridina |
US5202440A (en) * | 1987-10-05 | 1993-04-13 | Pfizer Inc. | Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines |
US4859669A (en) * | 1987-12-23 | 1989-08-22 | Schering Corporation | Antiinflammatory and anti-hyperproliferative naphthyridin-4-ones |
US5079360A (en) * | 1988-04-06 | 1992-01-07 | Schering Corporation | Processes for preparing bicyclic compounds and intermediates thereof |
US5180823A (en) * | 1988-04-06 | 1993-01-19 | Schering Corporation | Processes for preparing bicyclic compounds |
US4996212A (en) * | 1989-12-21 | 1991-02-26 | Schering Corporation | Antiinflammatory and anti-hyperproliferative compounds |
US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
AU2009333653B2 (en) * | 2008-12-17 | 2015-09-10 | Merck Patent Gmbh | C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof |
DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
CN113943288A (zh) * | 2020-07-17 | 2022-01-18 | 微境生物医药科技(上海)有限公司 | 5,6-二氢吡嗪并[2,3-c]异喹啉化合物 |
CN115611896A (zh) * | 2021-07-16 | 2023-01-17 | 中国药科大学 | 含四氢萘啶酮或四氢吡啶并嘧啶酮骨架的化合物及其制备方法与制药用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB855022A (en) * | 1957-08-06 | 1960-11-30 | Geigy Ag J R | Improvements in and relating to carbostyril derivatives |
IT1054655B (it) * | 1975-08-27 | 1981-11-30 | Lepetit Spa | Derivati condensati del l isochinolina |
JPS5854152B2 (ja) * | 1976-03-25 | 1983-12-02 | 久光製薬株式会社 | 新規なナフチリジン誘導体 |
EP0005745B1 (en) * | 1978-05-26 | 1982-07-14 | Gruppo Lepetit S.P.A. | Pyrazolo (3,4-c) and thiazolo (5,4-c) isoquinolines, methods for preparing them, these compounds for use as antiinflammatory, cns-depressant and anti-anxiety agents and pharmaceutical compositions thereof |
NL89090C (xx) * | 1978-06-05 | |||
US4452800A (en) * | 1982-04-26 | 1984-06-05 | Schering Corporation | Salts of 3(n-butyl)-4-hydroxy-1-phenyl-1,8-naphthyridine-2(1H)-one and their use in treating chronic obstructive lung diseases |
DE3368929D1 (de) * | 1982-04-26 | 1987-02-12 | Schering Corp | 1,8-naphthyridine and 1,5,8-azanaphthyridine derivatives |
-
1984
- 1984-04-09 US US06/597,887 patent/US4680298A/en not_active Expired - Lifetime
- 1984-05-24 DE DE8484105923T patent/DE3483064D1/de not_active Expired - Fee Related
- 1984-05-24 EP EP84105923A patent/EP0127135B1/en not_active Expired - Lifetime
- 1984-05-29 IL IL71960A patent/IL71960A/xx unknown
- 1984-05-29 PH PH30728A patent/PH22970A/en unknown
- 1984-05-29 GB GB08413582A patent/GB2142013B/en not_active Expired
- 1984-05-29 DK DK264784A patent/DK160557C/da not_active IP Right Cessation
- 1984-05-29 AU AU28824/84A patent/AU559754B2/en not_active Ceased
- 1984-05-29 NZ NZ208310A patent/NZ208310A/en unknown
- 1984-05-29 GR GR74858A patent/GR81552B/el unknown
- 1984-05-30 CA CA000455491A patent/CA1251208A/en not_active Expired
- 1984-05-30 JP JP59110656A patent/JPH0747590B2/ja not_active Expired - Lifetime
-
1990
- 1990-10-15 SG SG838/90A patent/SG83890G/en unknown
-
1992
- 1992-01-23 HK HK80/92A patent/HK8092A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US4680298A (en) | 1987-07-14 |
EP0127135A2 (en) | 1984-12-05 |
DK160557B (da) | 1991-03-25 |
DK264784A (da) | 1984-12-01 |
HK8092A (en) | 1992-01-31 |
SG83890G (en) | 1990-11-23 |
AU559754B2 (en) | 1987-03-19 |
AU2882484A (en) | 1984-12-06 |
GB8413582D0 (en) | 1984-07-04 |
GB2142013B (en) | 1987-01-21 |
GB2142013A (en) | 1985-01-09 |
IL71960A0 (en) | 1984-09-30 |
DK160557C (da) | 1991-09-09 |
CA1251208A (en) | 1989-03-14 |
DE3483064D1 (de) | 1990-10-04 |
EP0127135A3 (en) | 1985-08-21 |
DK264784D0 (da) | 1984-05-29 |
EP0127135B1 (en) | 1990-08-29 |
JPS6034967A (ja) | 1985-02-22 |
JPH0747590B2 (ja) | 1995-05-24 |
GR81552B (xx) | 1984-12-11 |
PH22970A (en) | 1989-02-10 |
NZ208310A (en) | 1986-11-12 |
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