IL67219A - Direct method for the preparation of 1-formyl congeners of indole-dihydroindole dimers present in an unseparated vinca rosea extract - Google Patents
Direct method for the preparation of 1-formyl congeners of indole-dihydroindole dimers present in an unseparated vinca rosea extractInfo
- Publication number
- IL67219A IL67219A IL67219A IL6721982A IL67219A IL 67219 A IL67219 A IL 67219A IL 67219 A IL67219 A IL 67219A IL 6721982 A IL6721982 A IL 6721982A IL 67219 A IL67219 A IL 67219A
- Authority
- IL
- Israel
- Prior art keywords
- unseparated
- indole
- preparation
- direct method
- rosea extract
- Prior art date
Links
- UKTNDLHXQNQKBH-UHFFFAOYSA-N 2,3-dihydro-1h-indole;1h-indole Chemical class C1=CC=C2NCCC2=C1.C1=CC=C2NC=CC2=C1 UKTNDLHXQNQKBH-UHFFFAOYSA-N 0.000 title 1
- 240000001829 Catharanthus roseus Species 0.000 title 1
- 239000000039 congener Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/321,662 US4375432A (en) | 1981-05-12 | 1981-11-16 | Method of preparing vincristine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL67219A true IL67219A (en) | 1985-09-29 |
Family
ID=23251481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL67219A IL67219A (en) | 1981-11-16 | 1982-11-10 | Direct method for the preparation of 1-formyl congeners of indole-dihydroindole dimers present in an unseparated vinca rosea extract |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4375432A (OSRAM) |
| EP (1) | EP0079785B1 (OSRAM) |
| JP (1) | JPS5890591A (OSRAM) |
| KR (1) | KR860000488B1 (OSRAM) |
| CA (1) | CA1180328A (OSRAM) |
| DE (1) | DE3277200D1 (OSRAM) |
| DK (1) | DK161254C (OSRAM) |
| GB (1) | GB2109378B (OSRAM) |
| GR (1) | GR77791B (OSRAM) |
| HU (1) | HU189620B (OSRAM) |
| IE (1) | IE54172B1 (OSRAM) |
| IL (1) | IL67219A (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU190219B (en) * | 1984-01-06 | 1986-08-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing in 3",7'-position cyclized dimer-cinca-alkaloid-derivatives |
| FR2582651B1 (fr) * | 1985-06-03 | 1987-08-28 | Pf Medicament | Procede de preparation de vincristine |
| WO2001024763A2 (en) | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| EP1235598A2 (en) * | 1999-11-12 | 2002-09-04 | Angiotech Pharmaceuticals, Inc. | Compositions of a combination of radioactive therapy and cell-cycle inhibitors |
| CA2511521C (en) | 2002-12-30 | 2012-02-07 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| CN115540503B (zh) * | 2022-10-28 | 2024-04-23 | 广州白云山汉方现代药业有限公司 | 一种硫酸长春新碱三元溶剂体系下的程序性干燥方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354163A (en) * | 1966-12-15 | 1967-11-21 | Eli Lillty And Company | Nu-desmethylvinblastine |
| GB1382460A (en) * | 1972-12-04 | 1975-01-29 | Richter Gedeon Vegyeszet | Vincristine separation process |
| US3899493A (en) * | 1972-12-29 | 1975-08-12 | Richter Gedeon Vegyeszet | Chromic acid oxidation of vinblastine sulfate to form vincristine |
| US4110330A (en) * | 1977-05-27 | 1978-08-29 | Eli Lilly And Company | 5'-Acetonylvincristine and related compounds |
| US4195022A (en) * | 1978-03-27 | 1980-03-25 | Eli Lilly And Company | 4-Desacetoxy-4α-hydroxyvinblastine and related compounds |
| HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
| HU183385B (en) * | 1980-04-02 | 1984-04-28 | Lilly Co Eli | Process for preparing vinca dimer derivatives |
| JPS57188596A (en) * | 1981-05-12 | 1982-11-19 | Lilly Co Eli | Manufacture of vinca dimer |
-
1981
- 1981-11-16 US US06/321,662 patent/US4375432A/en not_active Expired - Lifetime
-
1982
- 1982-11-10 IL IL67219A patent/IL67219A/xx not_active IP Right Cessation
- 1982-11-11 GR GR69790A patent/GR77791B/el unknown
- 1982-11-12 CA CA000415468A patent/CA1180328A/en not_active Expired
- 1982-11-12 JP JP57199652A patent/JPS5890591A/ja active Granted
- 1982-11-12 DK DK504882A patent/DK161254C/da not_active IP Right Cessation
- 1982-11-15 DE DE8282306057T patent/DE3277200D1/de not_active Expired
- 1982-11-15 IE IE2714/82A patent/IE54172B1/en not_active IP Right Cessation
- 1982-11-15 EP EP82306057A patent/EP0079785B1/en not_active Expired
- 1982-11-15 GB GB08232561A patent/GB2109378B/en not_active Expired
- 1982-11-16 HU HU823674A patent/HU189620B/hu unknown
- 1982-11-16 KR KR8205165A patent/KR860000488B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1180328A (en) | 1985-01-02 |
| JPH049792B2 (OSRAM) | 1992-02-21 |
| GB2109378B (en) | 1985-07-17 |
| DK161254C (da) | 1991-12-02 |
| GB2109378A (en) | 1983-06-02 |
| DK161254B (da) | 1991-06-17 |
| JPS5890591A (ja) | 1983-05-30 |
| EP0079785A2 (en) | 1983-05-25 |
| KR840002399A (ko) | 1984-07-02 |
| HU189620B (en) | 1986-07-28 |
| US4375432A (en) | 1983-03-01 |
| DE3277200D1 (en) | 1987-10-15 |
| EP0079785B1 (en) | 1987-09-09 |
| DK504882A (da) | 1983-05-17 |
| IE822714L (en) | 1983-05-16 |
| GR77791B (OSRAM) | 1984-09-25 |
| EP0079785A3 (en) | 1984-03-28 |
| IE54172B1 (en) | 1989-07-05 |
| KR860000488B1 (ko) | 1986-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXP | Patent expired |