IL65915A - Methods for producing a purified immunologically active tryptic peptide and for producing mono-specific antibodies to peptides prepared thereby - Google Patents
Methods for producing a purified immunologically active tryptic peptide and for producing mono-specific antibodies to peptides prepared therebyInfo
- Publication number
- IL65915A IL65915A IL65915A IL6591582A IL65915A IL 65915 A IL65915 A IL 65915A IL 65915 A IL65915 A IL 65915A IL 6591582 A IL6591582 A IL 6591582A IL 65915 A IL65915 A IL 65915A
- Authority
- IL
- Israel
- Prior art keywords
- producing
- tryptic peptide
- methods
- specific antibodies
- immunologically active
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57446—Specifically defined cancers of stomach or intestine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/269,115 US4468457A (en) | 1981-06-01 | 1981-06-01 | Method for producing a CSAp tryptic peptide and anti-CSAp antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
IL65915A0 IL65915A0 (en) | 1982-08-31 |
IL65915A true IL65915A (en) | 1985-07-31 |
Family
ID=23025864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL65915A IL65915A (en) | 1981-06-01 | 1982-05-31 | Methods for producing a purified immunologically active tryptic peptide and for producing mono-specific antibodies to peptides prepared thereby |
Country Status (9)
Country | Link |
---|---|
US (1) | US4468457A (de) |
EP (1) | EP0066786B1 (de) |
JP (1) | JPS58501355A (de) |
AT (1) | ATE19792T1 (de) |
AU (1) | AU550306B2 (de) |
CA (1) | CA1183451A (de) |
DE (1) | DE3271119D1 (de) |
IL (1) | IL65915A (de) |
WO (1) | WO1982004263A1 (de) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
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US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4454106A (en) * | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
DE3432714A1 (de) * | 1984-09-06 | 1986-04-24 | Behringwerke Ag, 3550 Marburg | Tumortherapeutikum und verfahren zu seiner herstellung |
US4962187A (en) * | 1984-11-28 | 1990-10-09 | Cota Biotech | Common antigen for colorectal and mucinous ovarian tumors and process for isolating the same |
ES8800604A1 (es) * | 1985-04-22 | 1987-11-16 | Hybritech Inc | Un metodo para producir anticuerpos monoclonales |
DK172686A (da) * | 1985-04-22 | 1986-10-23 | Hybritech Inc | Antigen opnaaet ud fra humant vaev, fremgangsmaade til under anvendelse af antigenet at fremstille monoklonale antistoffer til diagnose og behandling af cancer, fremgangsmaade til paavisning af cancer, samt antistoffer mod antigenet |
US5776093A (en) * | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
DK169987D0 (da) * | 1987-04-03 | 1987-04-03 | Jens Christian Jensenius | Human tumor-associated antigen, ca-ou1 |
CA1329119C (en) * | 1988-03-29 | 1994-05-03 | Milton David Goldenberg | Cytotoxic therapy |
US5925362A (en) * | 1993-08-11 | 1999-07-20 | Jenner Technologies | Method to elicit an antitumor response with human prostate-specific antigen |
US7011812B1 (en) | 1996-05-03 | 2006-03-14 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer and infectious diseases |
US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
ATE473242T1 (de) | 1998-05-20 | 2010-07-15 | Immunomedics Inc | Therapeutische mittel welche einen bispezifischen anti-hla class ii invariant chain x anti-pathogen antikörper enthalten |
US7138103B2 (en) * | 1998-06-22 | 2006-11-21 | Immunomedics, Inc. | Use of bi-specific antibodies for pre-targeting diagnosis and therapy |
US7405320B2 (en) | 1998-06-22 | 2008-07-29 | Immunomedics, Inc. | Therapeutic and diagnostic conjugates for use with multispecific antibodies |
US7833528B2 (en) * | 1998-06-22 | 2010-11-16 | Immunomedics, Inc. | Use of multispecific, non-covalent complexes for targeted delivery of therapeutics |
US6962702B2 (en) * | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
US7387772B1 (en) * | 1999-06-22 | 2008-06-17 | Immunimedics, Inc. | Chimeric, human and humanized anti-CSAP monoclonal antibodies |
US6361774B1 (en) | 1999-09-17 | 2002-03-26 | Immunomedics, Inc. | Methods and compositions for increasing the target-specific toxicity of a chemotherapy drug |
DE60040556D1 (de) | 1999-12-06 | 2008-11-27 | Univ Illinois | Hochaffine t-zellrezeptorproteine und verfahren |
US7897140B2 (en) | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
DE60129741T2 (de) * | 2000-06-20 | 2008-04-30 | Immunomedics, Inc. | Zielgerichtete kombinationsimmuntherapie für krebs und infektionskrankheiten |
US20020165149A1 (en) * | 2000-12-08 | 2002-11-07 | Kranz David M. | Mutated class II major histocompatibility proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
AU2002303181A1 (en) * | 2001-03-30 | 2002-10-15 | University Of Massachusetts | Morpholino imaging and therapy |
US8877901B2 (en) | 2002-12-13 | 2014-11-04 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
US7591994B2 (en) | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
EP1517684B1 (de) | 2002-06-27 | 2009-07-22 | Health Research, Inc. | Fluorinierte chlorin und bacteriochlorin photosensitizer für fotodynamische therapie |
AU2003249742A1 (en) | 2002-07-02 | 2004-01-23 | Health Research, Inc. | Efficient synthesis of pyropheophorbide a and its derivatives |
US20060024289A1 (en) * | 2002-10-02 | 2006-02-02 | Ruggles Sandra W | Cleavage of VEGF and VEGF receptor by wild-type and mutant proteases |
US7939304B2 (en) * | 2002-10-02 | 2011-05-10 | Catalyst Biosciences, Inc. | Mutant MT-SP1 proteases with altered substrate specificity or activity |
MXPA05008222A (es) | 2003-01-31 | 2005-10-05 | Immunomedics Inc | Metodos y composiciones para administrar agentes terapeuticos y de diagnostico. |
US7057100B2 (en) * | 2003-06-26 | 2006-06-06 | The J.C. Robinson Seed Co. | Inbred corn line W23129 |
EP1660519B1 (de) * | 2003-07-29 | 2014-05-14 | Immunomedics, Inc. | Konjugate von 2-[18F]Fluor-2-desoxy-D-glucose und einem Peptid-Molekül |
EP1733056B1 (de) | 2004-03-31 | 2013-05-22 | The General Hospital Corporation | Verfahren zur bestimmung des ansprechens eines tumors auf behandlungen mit dem epidermalen wachstumsfaktor-rezeptor als target |
CA2562729C (en) | 2004-04-12 | 2013-11-12 | Sandra Waugh Ruggles | Cleavage of vegf and vegf receptor by wildtype and mutant mt-sp1 |
US20050260131A1 (en) * | 2004-05-20 | 2005-11-24 | General Electric Company | Pharmaceuticals for enhanced delivery to disease targets |
PT2298815E (pt) | 2005-07-25 | 2015-07-16 | Emergent Product Dev Seattle | Moléculas de ligaçao especificas para cd37 e especificas para cd20 |
EP2674440B1 (de) | 2005-12-16 | 2019-07-03 | IBC Pharmaceuticals, Inc. | Polyvalente bioaktive anordnungen auf immunglobulinbasis |
MX2008015524A (es) | 2006-06-12 | 2009-01-13 | Trubion Pharmaceuticals Inc | Proteinas de union multivalentes monocatenarias con funcion efectora. |
KR101476458B1 (ko) | 2006-07-05 | 2015-01-05 | 카탈리스트 바이오사이언시즈, 인코포레이티드 | 프로테아제 스크리닝 방법 및 이에 의해 확인된 프로테아제 |
WO2009126944A1 (en) | 2008-04-11 | 2009-10-15 | Trubion Pharmaceuticals, Inc. | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
CN102448494B (zh) | 2009-02-13 | 2016-02-03 | 免疫医疗公司 | 具有胞内可裂解的键的免疫共轭物 |
US8012770B2 (en) | 2009-07-31 | 2011-09-06 | Invisible Sentinel, Inc. | Device for detection of antigens and uses thereof |
US10464987B2 (en) | 2009-10-06 | 2019-11-05 | Abbvie Inc. | Human single-chain T cell receptors |
MX2012004105A (es) | 2009-10-09 | 2012-09-07 | Invisible Sentinel Inc | Dispositivo para deteccion de antigenos y usos del mismo. |
EP2668501B1 (de) | 2011-01-27 | 2019-06-12 | Invisible Sentinel, Inc. | Analytnachweisvorrichtungen, multiplex- und tischplattenvorrichtungen für den nachweis von analyten und verwendungen davon |
WO2013096455A1 (en) | 2011-12-20 | 2013-06-27 | Dana-Farber Cancer Institute, Inc. | Methods for diagnosing and treating oncogenic kras-associated cancer |
CN104919055B (zh) | 2012-03-09 | 2018-06-19 | 因威瑟堡善迪诺有限公司 | 用单一信号检测多种分析物的方法和组合物 |
US10138479B2 (en) | 2012-05-24 | 2018-11-27 | Dana-Farber Cancer Institute, Inc. | Targeting the glutamine to pyruvate pathway for treatment of oncogenic Kras-associated cancer |
US20150285802A1 (en) | 2012-07-18 | 2015-10-08 | Dana-Farber Cancer Institute, Inc. | Methods for treating, preventing and predicting risk of developing breast cancer |
NZ704157A (en) | 2012-07-27 | 2018-08-31 | Univ Illinois | Engineering t-cell receptors |
CA2874864C (en) | 2012-08-14 | 2023-02-21 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
PL2900277T3 (pl) | 2012-12-13 | 2022-05-16 | Immunomedics, Inc. | Dawkowanie immunokoniugatów przeciwciał i sn-38 dla poprawy skuteczności i zmniejszenia toksyczności |
WO2017004144A1 (en) | 2015-07-01 | 2017-01-05 | Immunomedics, Inc. | Antibody-sn-38 immunoconjugates with a cl2a linker |
US9931412B2 (en) | 2013-02-08 | 2018-04-03 | The Regents Of The University Of Michigan | Targeted theranostics |
US20150050697A1 (en) | 2013-08-19 | 2015-02-19 | Abbott Molecular Inc. | Nucleotide analogs |
US10130590B2 (en) | 2013-10-01 | 2018-11-20 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancer with atovaquone-related compounds |
CN105873945B (zh) | 2013-11-22 | 2020-07-17 | 伊利诺伊州大学理事会 | 工程化的高亲和力人类t细胞受体 |
US10350264B2 (en) | 2014-03-27 | 2019-07-16 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin |
US10555926B2 (en) | 2015-02-17 | 2020-02-11 | Erasmus University Medical Center Rotterdam | Use of cabazitaxel in the treatment of prostate cancer |
MY197562A (en) | 2015-09-21 | 2023-06-23 | Aptevo Res & Development Llc | Cd3 binding polypeptides |
WO2017151836A1 (en) | 2016-03-04 | 2017-09-08 | East Carolina University | J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders |
WO2018035281A1 (en) | 2016-08-17 | 2018-02-22 | North Carolina State University | Northern-southern route to synthesis of bacteriochlorins |
US10836774B2 (en) | 2016-11-30 | 2020-11-17 | North Carolina State University | Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds |
EP4265257A1 (de) | 2017-09-01 | 2023-10-25 | East Carolina University | Kombination eines prostaglandin-ethanolamids der j-serie und eines checkpoint-inhibitors zur verwendung bei der behandlung von krebs |
CN114222803A (zh) | 2019-05-20 | 2022-03-22 | 尼尔瓦纳科学股份有限公司 | 窄发射染料、包含其的组合物以及制备和使用其的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2719102A (en) * | 1949-10-28 | 1955-09-27 | Corn States Serum Company | Clostridium perfringens toxoid and process of making the same |
US4086217A (en) * | 1976-03-03 | 1978-04-25 | Hoffmann-La Roche Inc. | Carcinoembryonic antigens |
US4228236A (en) * | 1978-05-15 | 1980-10-14 | Northwestern University | Process of producing carcinoembryonic antigen |
-
1981
- 1981-06-01 US US06/269,115 patent/US4468457A/en not_active Expired - Fee Related
-
1982
- 1982-05-27 EP EP82104604A patent/EP0066786B1/de not_active Expired
- 1982-05-27 DE DE8282104604T patent/DE3271119D1/de not_active Expired
- 1982-05-27 AT AT82104604T patent/ATE19792T1/de not_active IP Right Cessation
- 1982-05-31 CA CA000404077A patent/CA1183451A/en not_active Expired
- 1982-05-31 IL IL65915A patent/IL65915A/xx unknown
- 1982-06-01 WO PCT/US1982/000746 patent/WO1982004263A1/en unknown
- 1982-06-01 AU AU87318/82A patent/AU550306B2/en not_active Ceased
- 1982-06-01 JP JP57502209A patent/JPS58501355A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA1183451A (en) | 1985-03-05 |
IL65915A0 (en) | 1982-08-31 |
EP0066786A2 (de) | 1982-12-15 |
DE3271119D1 (en) | 1986-06-19 |
WO1982004263A1 (en) | 1982-12-09 |
ATE19792T1 (de) | 1986-05-15 |
AU8731882A (en) | 1982-12-07 |
JPS58501355A (ja) | 1983-08-18 |
EP0066786B1 (de) | 1986-05-14 |
US4468457A (en) | 1984-08-28 |
AU550306B2 (en) | 1986-03-13 |
EP0066786A3 (en) | 1983-07-20 |
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