IL65061A - Stable high copy number plasmids and method for increasing protein production thereby - Google Patents

Stable high copy number plasmids and method for increasing protein production thereby

Info

Publication number
IL65061A
IL65061A IL65061A IL6506182A IL65061A IL 65061 A IL65061 A IL 65061A IL 65061 A IL65061 A IL 65061A IL 6506182 A IL6506182 A IL 6506182A IL 65061 A IL65061 A IL 65061A
Authority
IL
Israel
Prior art keywords
copy number
protein production
stable high
high copy
increasing protein
Prior art date
Application number
IL65061A
Other languages
English (en)
Other versions
IL65061A0 (en
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of IL65061A0 publication Critical patent/IL65061A0/xx
Publication of IL65061A publication Critical patent/IL65061A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL65061A 1981-02-27 1982-02-19 Stable high copy number plasmids and method for increasing protein production thereby IL65061A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23916581A 1981-02-27 1981-02-27

Publications (2)

Publication Number Publication Date
IL65061A0 IL65061A0 (en) 1982-04-30
IL65061A true IL65061A (en) 1986-01-31

Family

ID=22900899

Family Applications (1)

Application Number Title Priority Date Filing Date
IL65061A IL65061A (en) 1981-02-27 1982-02-19 Stable high copy number plasmids and method for increasing protein production thereby

Country Status (11)

Country Link
EP (1) EP0060045A3 (xx)
JP (1) JPS57172000A (xx)
AU (1) AU554700B2 (xx)
BR (1) BR8201015A (xx)
CA (1) CA1198067A (xx)
DK (1) DK85682A (xx)
ES (1) ES8305415A1 (xx)
FI (1) FI820688L (xx)
IL (1) IL65061A (xx)
NO (1) NO820610L (xx)
WO (1) WO1982002901A1 (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1198069A (en) * 1982-06-08 1985-12-17 David H. Gelfand Temperature sensitive multicopy plasmids
HU201116B (en) * 1982-09-16 1990-09-28 Benzon As Alfred Process for producing plasmids having uncontrolled replication conduct under given circumstances
CA1209501A (en) * 1982-09-16 1986-08-12 Nikos Panayotatos Expression vector
NL8203716A (nl) * 1982-09-24 1984-04-16 Tno Dna en plasmiden.
GB8308236D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Dna vectors
US5670371A (en) * 1983-07-15 1997-09-23 Bio-Technology General Corp. Bacterial expression of superoxide dismutase
US4710473A (en) * 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
HU194307B (en) * 1983-09-16 1988-01-28 Richter Gedeon Vegyeszet Process for producing plasmidvectors of high copy number
DE3585170D1 (de) 1984-03-06 1992-02-27 Lilly Co Eli Expressionsvektoren fuer rinderwachstumshormonderivate.
US4753886A (en) * 1984-08-10 1988-06-28 Eli Lilly And Company Plasmid PHJL210 and related bifunctional cloning vectors for use in streptomycetes
GB2166743B (en) * 1984-11-13 1989-01-05 Solvay Process for a thermo-inducible gene expression in gram positive bacteria and bacillus subtilis strains containing plasmids which induce such an expression
US7998732B2 (en) 2004-02-04 2011-08-16 Merck Sharp & Dohme Corp. Process for large scale production of plasmid DNA by E. coli fermentation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322499A (en) * 1978-12-22 1982-03-30 The Regents Of The University Of California Adrenocorticotropin-lipotropin precursor gene
FI793884A (fi) * 1978-12-26 1980-06-27 Cetus Corp Stabila plasmider med stort kopieantal

Also Published As

Publication number Publication date
WO1982002901A1 (en) 1982-09-02
EP0060045A3 (en) 1983-08-24
BR8201015A (pt) 1983-01-04
NO820610L (no) 1982-08-30
AU554700B2 (en) 1986-08-28
FI820688L (fi) 1982-08-28
ES509946A0 (es) 1983-04-01
DK85682A (da) 1982-08-28
IL65061A0 (en) 1982-04-30
EP0060045A2 (en) 1982-09-15
AU8274782A (en) 1982-09-14
JPS57172000A (en) 1982-10-22
CA1198067A (en) 1985-12-17
ES8305415A1 (es) 1983-04-01

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