IL64822A - Process for the preparation of carnitin amide in the form of its chloride - Google Patents
Process for the preparation of carnitin amide in the form of its chlorideInfo
- Publication number
- IL64822A IL64822A IL64822A IL6482282A IL64822A IL 64822 A IL64822 A IL 64822A IL 64822 A IL64822 A IL 64822A IL 6482282 A IL6482282 A IL 6482282A IL 64822 A IL64822 A IL 64822A
- Authority
- IL
- Israel
- Prior art keywords
- ethyl ester
- chloride
- amide
- carnitine
- pressure
- Prior art date
Links
- KWIXGIMKELMNGH-UHFFFAOYSA-O carnitinamide Chemical compound C[N+](C)(C)CC(O)CC(N)=O KWIXGIMKELMNGH-UHFFFAOYSA-O 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 title 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 229960004203 carnitine Drugs 0.000 abstract 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 229940095054 ammoniac Drugs 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001805 chlorine compounds Chemical class 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- OHLRLMWUFVDREV-UHFFFAOYSA-N ethyl 4-chloro-3-oxobutanoate Chemical compound CCOC(=O)CC(=O)CCl OHLRLMWUFVDREV-UHFFFAOYSA-N 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH363/81A CH648287A5 (de) | 1981-01-21 | 1981-01-21 | Verfahren zur herstellung von carnitinamid. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL64822A0 IL64822A0 (en) | 1982-03-31 |
| IL64822A true IL64822A (en) | 1986-01-31 |
Family
ID=4185314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL64822A IL64822A (en) | 1981-01-21 | 1982-01-20 | Process for the preparation of carnitin amide in the form of its chloride |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4443627A (xx) |
| EP (1) | EP0056615B1 (xx) |
| JP (1) | JPS57140749A (xx) |
| AT (1) | ATE7899T1 (xx) |
| CA (1) | CA1189535A (xx) |
| CH (1) | CH648287A5 (xx) |
| CS (1) | CS223900B2 (xx) |
| DD (1) | DD202003A5 (xx) |
| DE (1) | DE3260254D1 (xx) |
| ES (1) | ES8300683A1 (xx) |
| HU (1) | HU191813B (xx) |
| IL (1) | IL64822A (xx) |
| SU (1) | SU1149872A3 (xx) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3420391C1 (de) * | 1984-06-01 | 1985-08-14 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von D,L-Carnitinamidchlorid |
| US5258552A (en) * | 1986-06-04 | 1993-11-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | N-alkylamides of d(+)-carnitine having antibacterial activity, process for their preparation and pharmaceutical and cosmetic compositions containing same |
| EP2216321A1 (en) * | 2009-02-05 | 2010-08-11 | Lonza Ltd. | Process for the production of a fatty acid/carnitine derivative |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2087565A (en) * | 1931-06-24 | 1937-07-20 | Gen Aniline Works Inc | Quaternary ammonium compounds and a process of preparing them |
| US3072722A (en) * | 1955-07-21 | 1963-01-08 | Upjohn Co | Preparation of amides of 4-tertiary amino-lower 4-alkylbutyric acids |
| US3096244A (en) * | 1956-11-06 | 1963-07-02 | Hoechst Ag | Substituted butyric acid amide and analgesia |
| US3155658A (en) * | 1960-12-21 | 1964-11-03 | Gen Mills Inc | Aminohydroxy fatty amides |
| BE661015A (xx) * | 1965-03-12 | 1965-09-13 | ||
| CH596147A5 (xx) * | 1974-09-25 | 1978-02-28 | Lonza Ag | |
| IT1156852B (it) * | 1978-07-10 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni |
-
1981
- 1981-01-21 CH CH363/81A patent/CH648287A5/de not_active IP Right Cessation
-
1982
- 1982-01-13 EP EP82100196A patent/EP0056615B1/de not_active Expired
- 1982-01-13 DE DE8282100196T patent/DE3260254D1/de not_active Expired
- 1982-01-13 AT AT82100196T patent/ATE7899T1/de not_active IP Right Cessation
- 1982-01-19 JP JP57006718A patent/JPS57140749A/ja active Pending
- 1982-01-20 DD DD82236881A patent/DD202003A5/de unknown
- 1982-01-20 US US06/341,009 patent/US4443627A/en not_active Expired - Fee Related
- 1982-01-20 SU SU823431252A patent/SU1149872A3/ru active
- 1982-01-20 ES ES508889A patent/ES8300683A1/es not_active Expired
- 1982-01-20 CS CS82402A patent/CS223900B2/cs unknown
- 1982-01-20 IL IL64822A patent/IL64822A/xx unknown
- 1982-01-21 CA CA000394670A patent/CA1189535A/en not_active Expired
- 1982-01-21 HU HU82171A patent/HU191813B/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES508889A0 (es) | 1982-11-01 |
| ES8300683A1 (es) | 1982-11-01 |
| HU191813B (en) | 1987-04-28 |
| EP0056615A2 (de) | 1982-07-28 |
| CS223900B2 (en) | 1983-11-25 |
| IL64822A0 (en) | 1982-03-31 |
| US4443627A (en) | 1984-04-17 |
| ATE7899T1 (de) | 1984-06-15 |
| JPS57140749A (en) | 1982-08-31 |
| CH648287A5 (de) | 1985-03-15 |
| DE3260254D1 (en) | 1984-07-19 |
| DD202003A5 (de) | 1983-08-24 |
| EP0056615A3 (en) | 1982-08-11 |
| CA1189535A (en) | 1985-06-25 |
| SU1149872A3 (en) | 1985-04-07 |
| EP0056615B1 (de) | 1984-06-13 |
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