IL64253A - Dimeric 1,4-dihydropyridine compounds linked in the c-3 position,their production and pharmaceutical compositions containing them - Google Patents
Dimeric 1,4-dihydropyridine compounds linked in the c-3 position,their production and pharmaceutical compositions containing themInfo
- Publication number
- IL64253A IL64253A IL64253A IL6425381A IL64253A IL 64253 A IL64253 A IL 64253A IL 64253 A IL64253 A IL 64253A IL 6425381 A IL6425381 A IL 6425381A IL 64253 A IL64253 A IL 64253A
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- different
- phenyl
- alkyl
- hydroxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1. 1,4-Dihydropyridines which are linked in the C-3 position, of the general formula I see diagramm : EP0052300,P19,F4 in which R and R' are identical or different and each represent a phenyl radical or a thienyl, furyl, or pyridyl radical, the phenyl radical is optionally substituted by one or two identical or different substituents from the group comprising nitro, cyano, azido, halogen, trifluoromethyl, hydroxyl, amino, alkyl, alkoxy, alkylamino or alkylmercapto, with in each case 1 or 2 carbon atoms in the alkyl groups, R**1 and R**1' are identical or different and each represent a straight-chain or branched hydrocarbon radical having up to 6 carbon atoms which is optionally interrupted in the chain by an oxygen atom and which is optionally substituted by fluorine, chlorine, hydroxyl, phenyl or phenoxy, R**2 , R**2' , R**4 and R**4' are identical or different and each represent hydrogen or a straight-chain or branched alkyl radical which has up to 4 carbon atoms and which is optionally substituted by fluorine, chlorine, hydroxyl, phenyl or amino, R**3 and R**3' are identical or different and each represent hydrogen, alkyl having 1 to 4 carbon atoms, phenyl, benzyl or phenethyl, optionally substituted by hydroxyl, fluorine or chlorine, Y and Y' are in each case identical or different and each denote - COO -, - CONH -, - CO - or - SO2 - and X denotes a bridge member which consists of one to ten CH2 groups as the chain member, and none of these CH2 groups are allowed as a ring member, it being possible for this bridge member additionally to contain, in any sequence, 1 to 3 identical or different chain members from the group comprising O, S, CO, CS, NR**5 , C(R**6 )2 , CH = N, phenylene, naphthylene, pyrrylene, cycloalkylene with 5 to 7 carbon atoms, piperazinylene, piperidinylene, pyrrolidinylene or morpholinylene, wherein R**5 represents hydrogen, benzyl or alkyl having 1 to 4 carbon atoms and R**6 represents hydrogen, benzyl, phenyl, fluorine, chlorine, alkyl having 1 to 4 carbon atoms, hydroxyl, trifluoromethyl, cyano, carboxyl or amino and their pharmacologically acceptable acid addition salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19803042769 DE3042769A1 (en) | 1980-11-13 | 1980-11-13 | C-3 LINKED 1,4-DIHYDROPYRIDINE, THEIR USE IN MEDICINAL PRODUCTS AND METHOD FOR THE PRODUCTION THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL64253A0 IL64253A0 (en) | 1982-02-28 |
| IL64253A true IL64253A (en) | 1985-03-31 |
Family
ID=6116648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL64253A IL64253A (en) | 1980-11-13 | 1981-11-10 | Dimeric 1,4-dihydropyridine compounds linked in the c-3 position,their production and pharmaceutical compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0052300B1 (en) |
| JP (1) | JPS57109766A (en) |
| AT (1) | ATE11773T1 (en) |
| AU (1) | AU546605B2 (en) |
| CA (1) | CA1179342A (en) |
| DD (1) | DD201900A5 (en) |
| DE (2) | DE3042769A1 (en) |
| DK (1) | DK501881A (en) |
| ES (3) | ES8206477A1 (en) |
| FI (1) | FI813567L (en) |
| GR (1) | GR76338B (en) |
| HU (1) | HU186438B (en) |
| IL (1) | IL64253A (en) |
| NO (1) | NO813649L (en) |
| PT (1) | PT73920B (en) |
| ZA (1) | ZA817840B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3208628A1 (en) * | 1982-03-10 | 1983-09-22 | Bayer Ag, 5090 Leverkusen | NEW COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS |
| ATE50987T1 (en) * | 1982-05-10 | 1990-03-15 | Takeda Chemical Industries Ltd | DIHYDROPYRIDE DERIVATIVES, THEIR PREPARATION AND USE. |
| US4656181A (en) * | 1982-11-24 | 1987-04-07 | Cermol S.A. | Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same |
| EP0145956A1 (en) * | 1983-11-16 | 1985-06-26 | Ciba-Geigy Ag | Composés amidés |
| JPS60120861A (en) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | Dihydropyridine derivative |
| US4672068A (en) * | 1984-05-04 | 1987-06-09 | Fujirebio Kabushiki Kaisha | Antihypertensive 1,4-dihydropyridines having a conjugated ester |
| US4757071A (en) * | 1984-12-14 | 1988-07-12 | Nisshin Flour Milling Co., Ltd. | 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases |
| IT1203900B (en) * | 1987-04-15 | 1989-02-23 | Lagor Spa | POLES 1,4-DIHYDRO-2,6-DIMETHYLPYRIDIN 3,5-DICARBOXYESTERS USEFUL AS THERMAL STABILIZERS FOR SYNTHETIC POLYMERS |
| IL91382A (en) * | 1988-09-01 | 1995-06-29 | Orion Yhtymae Oy | Alkenyl or arylmethylene-substituted beta-diketones their preparation and pharmaceutical compositions containing them |
| GB9002337D0 (en) * | 1990-02-02 | 1990-04-04 | Orion Yhtymae Oy | Compounds useful in treating inflammatory bowel disease |
| US5185370A (en) * | 1988-09-01 | 1993-02-09 | Orion-Yhtyma Oy | Substituted β-diketones and their use |
| CA2318901A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Novel calcium channel drugs and uses |
| US6897305B2 (en) | 1998-06-08 | 2005-05-24 | Theravance, Inc. | Calcium channel drugs and uses |
| US7101909B2 (en) | 1998-10-12 | 2006-09-05 | Theravance, Inc. | Calcium channel drugs and uses |
| GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1795791A1 (en) * | 1966-11-16 | 1975-06-19 | Astra Ab | PYRIDINE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM |
| DE2117571C3 (en) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Asymmetrical 1,4-dihydropyridine-33-dicarboxylic acid esters, process for their preparation and their use as pharmaceuticals |
| DE2847236A1 (en) * | 1978-10-31 | 1980-05-14 | Bayer Ag | NEW DIHYDROPYRIDINE WITH SUBSTITUTED ESTER GROUPS, MORE PROCEDURES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS |
-
1980
- 1980-11-13 DE DE19803042769 patent/DE3042769A1/en not_active Withdrawn
-
1981
- 1981-10-28 NO NO813649A patent/NO813649L/en unknown
- 1981-10-31 AT AT81109456T patent/ATE11773T1/en not_active IP Right Cessation
- 1981-10-31 DE DE8181109456T patent/DE3168955D1/en not_active Expired
- 1981-10-31 EP EP81109456A patent/EP0052300B1/en not_active Expired
- 1981-11-03 PT PT73920A patent/PT73920B/en unknown
- 1981-11-05 AU AU77110/81A patent/AU546605B2/en not_active Ceased
- 1981-11-09 DD DD81234718A patent/DD201900A5/en unknown
- 1981-11-10 IL IL64253A patent/IL64253A/en unknown
- 1981-11-10 CA CA000389828A patent/CA1179342A/en not_active Expired
- 1981-11-11 FI FI813567A patent/FI813567L/en not_active Application Discontinuation
- 1981-11-11 GR GR66490A patent/GR76338B/el unknown
- 1981-11-12 DK DK501881A patent/DK501881A/en unknown
- 1981-11-12 JP JP56180437A patent/JPS57109766A/en active Pending
- 1981-11-12 ZA ZA817840A patent/ZA817840B/en unknown
- 1981-11-12 ES ES507080A patent/ES8206477A1/en not_active Expired
- 1981-11-13 HU HU813401A patent/HU186438B/en unknown
-
1982
- 1982-03-09 ES ES510253A patent/ES510253A0/en active Granted
- 1982-03-09 ES ES510254A patent/ES8303337A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK501881A (en) | 1982-05-14 |
| ES507080A0 (en) | 1982-08-16 |
| DE3042769A1 (en) | 1982-06-09 |
| IL64253A0 (en) | 1982-02-28 |
| EP0052300B1 (en) | 1985-02-13 |
| DD201900A5 (en) | 1983-08-17 |
| HU186438B (en) | 1985-07-29 |
| ZA817840B (en) | 1982-10-27 |
| AU7711081A (en) | 1982-05-20 |
| CA1179342A (en) | 1984-12-11 |
| JPS57109766A (en) | 1982-07-08 |
| PT73920A (en) | 1981-12-01 |
| GR76338B (en) | 1984-08-04 |
| EP0052300A1 (en) | 1982-05-26 |
| ES510254A0 (en) | 1983-02-01 |
| ATE11773T1 (en) | 1985-02-15 |
| DE3168955D1 (en) | 1985-03-28 |
| ES8303336A1 (en) | 1983-02-01 |
| FI813567L (en) | 1982-05-14 |
| PT73920B (en) | 1983-03-29 |
| ES8206477A1 (en) | 1982-08-16 |
| NO813649L (en) | 1982-05-14 |
| AU546605B2 (en) | 1985-09-12 |
| ES510253A0 (en) | 1983-02-01 |
| ES8303337A1 (en) | 1983-02-01 |
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