AU7711081A - Dihydropyridines linked in the c-3 position - Google Patents

Dihydropyridines linked in the c-3 position

Info

Publication number
AU7711081A
AU7711081A AU77110/81A AU7711081A AU7711081A AU 7711081 A AU7711081 A AU 7711081A AU 77110/81 A AU77110/81 A AU 77110/81A AU 7711081 A AU7711081 A AU 7711081A AU 7711081 A AU7711081 A AU 7711081A
Authority
AU
Australia
Prior art keywords
carbon atoms
different
phenyl
alkyl
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU77110/81A
Other versions
AU546605B2 (en
Inventor
Siegfried Goldmann
Andreas Knorr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU7711081A publication Critical patent/AU7711081A/en
Application granted granted Critical
Publication of AU546605B2 publication Critical patent/AU546605B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. 1,4-Dihydropyridines which are linked in the C-3 position, of the general formula I see diagramm : EP0052300,P19,F4 in which R and R' are identical or different and each represent a phenyl radical or a thienyl, furyl, or pyridyl radical, the phenyl radical is optionally substituted by one or two identical or different substituents from the group comprising nitro, cyano, azido, halogen, trifluoromethyl, hydroxyl, amino, alkyl, alkoxy, alkylamino or alkylmercapto, with in each case 1 or 2 carbon atoms in the alkyl groups, R**1 and R**1' are identical or different and each represent a straight-chain or branched hydrocarbon radical having up to 6 carbon atoms which is optionally interrupted in the chain by an oxygen atom and which is optionally substituted by fluorine, chlorine, hydroxyl, phenyl or phenoxy, R**2 , R**2' , R**4 and R**4' are identical or different and each represent hydrogen or a straight-chain or branched alkyl radical which has up to 4 carbon atoms and which is optionally substituted by fluorine, chlorine, hydroxyl, phenyl or amino, R**3 and R**3' are identical or different and each represent hydrogen, alkyl having 1 to 4 carbon atoms, phenyl, benzyl or phenethyl, optionally substituted by hydroxyl, fluorine or chlorine, Y and Y' are in each case identical or different and each denote - COO -, - CONH -, - CO - or - SO2 - and X denotes a bridge member which consists of one to ten CH2 groups as the chain member, and none of these CH2 groups are allowed as a ring member, it being possible for this bridge member additionally to contain, in any sequence, 1 to 3 identical or different chain members from the group comprising O, S, CO, CS, NR**5 , C(R**6 )2 , CH = N, phenylene, naphthylene, pyrrylene, cycloalkylene with 5 to 7 carbon atoms, piperazinylene, piperidinylene, pyrrolidinylene or morpholinylene, wherein R**5 represents hydrogen, benzyl or alkyl having 1 to 4 carbon atoms and R**6 represents hydrogen, benzyl, phenyl, fluorine, chlorine, alkyl having 1 to 4 carbon atoms, hydroxyl, trifluoromethyl, cyano, carboxyl or amino and their pharmacologically acceptable acid addition salts.
AU77110/81A 1980-11-13 1981-11-05 Dihydropyridines linked in the c-3 position Ceased AU546605B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803042769 DE3042769A1 (en) 1980-11-13 1980-11-13 C-3 LINKED 1,4-DIHYDROPYRIDINE, THEIR USE IN MEDICINAL PRODUCTS AND METHOD FOR THE PRODUCTION THEREOF
DE30427691 1980-11-13

Publications (2)

Publication Number Publication Date
AU7711081A true AU7711081A (en) 1982-05-20
AU546605B2 AU546605B2 (en) 1985-09-12

Family

ID=6116648

Family Applications (1)

Application Number Title Priority Date Filing Date
AU77110/81A Ceased AU546605B2 (en) 1980-11-13 1981-11-05 Dihydropyridines linked in the c-3 position

Country Status (16)

Country Link
EP (1) EP0052300B1 (en)
JP (1) JPS57109766A (en)
AT (1) ATE11773T1 (en)
AU (1) AU546605B2 (en)
CA (1) CA1179342A (en)
DD (1) DD201900A5 (en)
DE (2) DE3042769A1 (en)
DK (1) DK501881A (en)
ES (3) ES8206477A1 (en)
FI (1) FI813567L (en)
GR (1) GR76338B (en)
HU (1) HU186438B (en)
IL (1) IL64253A (en)
NO (1) NO813649L (en)
PT (1) PT73920B (en)
ZA (1) ZA817840B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3208628A1 (en) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen NEW COMPOUNDS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
EP0094159B1 (en) * 1982-05-10 1990-03-14 Takeda Chemical Industries, Ltd. Dihydropyridine derivatives, their production and use
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
EP0145956A1 (en) * 1983-11-16 1985-06-26 Ciba-Geigy Ag Composés amidés
JPS60120861A (en) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd Dihydropyridine derivative
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases
IT1203900B (en) * 1987-04-15 1989-02-23 Lagor Spa POLES 1,4-DIHYDRO-2,6-DIMETHYLPYRIDIN 3,5-DICARBOXYESTERS USEFUL AS THERMAL STABILIZERS FOR SYNTHETIC POLYMERS
US5185370A (en) * 1988-09-01 1993-02-09 Orion-Yhtyma Oy Substituted β-diketones and their use
GB9002337D0 (en) * 1990-02-02 1990-04-04 Orion Yhtymae Oy Compounds useful in treating inflammatory bowel disease
IL91382A (en) * 1988-09-01 1995-06-29 Orion Yhtymae Oy Alkenyl or arylmethylene-substituted beta-diketones their preparation and pharmaceutical compositions containing them
JP2002517440A (en) * 1998-06-08 2002-06-18 アドバンスド メディスン インコーポレーテッド New calcium channel drugs and uses
US6897305B2 (en) 1998-06-08 2005-05-24 Theravance, Inc. Calcium channel drugs and uses
US7101909B2 (en) 1998-10-12 2006-09-05 Theravance, Inc. Calcium channel drugs and uses
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795788A1 (en) * 1966-11-16 1975-07-31 Astra Ab PYRIDINE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM
DE2117571C3 (en) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Asymmetrical 1,4-dihydropyridine-33-dicarboxylic acid esters, process for their preparation and their use as pharmaceuticals
DE2847236A1 (en) * 1978-10-31 1980-05-14 Bayer Ag NEW DIHYDROPYRIDINE WITH SUBSTITUTED ESTER GROUPS, MORE PROCEDURES FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
IL64253A0 (en) 1982-02-28
ES507080A0 (en) 1982-08-16
ES510254A0 (en) 1983-02-01
AU546605B2 (en) 1985-09-12
PT73920B (en) 1983-03-29
CA1179342A (en) 1984-12-11
DE3042769A1 (en) 1982-06-09
JPS57109766A (en) 1982-07-08
ES8303336A1 (en) 1983-02-01
GR76338B (en) 1984-08-04
FI813567L (en) 1982-05-14
DE3168955D1 (en) 1985-03-28
PT73920A (en) 1981-12-01
ATE11773T1 (en) 1985-02-15
ES8303337A1 (en) 1983-02-01
ZA817840B (en) 1982-10-27
HU186438B (en) 1985-07-29
DK501881A (en) 1982-05-14
EP0052300A1 (en) 1982-05-26
IL64253A (en) 1985-03-31
EP0052300B1 (en) 1985-02-13
DD201900A5 (en) 1983-08-17
ES510253A0 (en) 1983-02-01
ES8206477A1 (en) 1982-08-16
NO813649L (en) 1982-05-14

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