IL60095A - Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophen - Google Patents
Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophenInfo
- Publication number
- IL60095A IL60095A IL60095A IL6009580A IL60095A IL 60095 A IL60095 A IL 60095A IL 60095 A IL60095 A IL 60095A IL 6009580 A IL6009580 A IL 6009580A IL 60095 A IL60095 A IL 60095A
- Authority
- IL
- Israel
- Prior art keywords
- nalbuphine
- acetaminophen
- pharmaceutical compositions
- analgesic pharmaceutical
- synergistic analgesic
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title 2
- 230000000202 analgesic effect Effects 0.000 title 1
- NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 title 1
- 229960000805 nalbuphine Drugs 0.000 title 1
- 229960005489 paracetamol Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000002195 synergetic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/040,281 US4237140A (en) | 1979-05-18 | 1979-05-18 | Analgesic mixture of nalbuphine and acetaminophen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL60095A0 IL60095A0 (en) | 1980-07-31 |
| IL60095A true IL60095A (en) | 1982-12-31 |
Family
ID=21910135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL60095A IL60095A (en) | 1979-05-18 | 1980-05-16 | Synergistic analgesic pharmaceutical compositions comprising nalbuphine and acetaminophen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4237140A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0019282B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPS55154917A (cg-RX-API-DMAC10.html) |
| AU (1) | AU529764B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA1139671A (cg-RX-API-DMAC10.html) |
| DE (1) | DE3061597D1 (cg-RX-API-DMAC10.html) |
| HU (1) | HU178867B (cg-RX-API-DMAC10.html) |
| IE (1) | IE49988B1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL60095A (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ193695A (cg-RX-API-DMAC10.html) |
| PH (1) | PH15265A (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA802916B (cg-RX-API-DMAC10.html) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322427A (en) * | 1981-04-16 | 1982-03-30 | Bristol-Myers Company | Analgetic compositions and methods of use |
| US4366159A (en) * | 1981-09-08 | 1982-12-28 | Michael Richard Magruder | Nalbuphine-narcotic analgesic composition and method of producing analgesia |
| US4407805A (en) * | 1982-06-30 | 1983-10-04 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and zomepirac |
| US4404209A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and sulindac |
| US4404210A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and ibuprofen |
| US4407804A (en) * | 1982-06-30 | 1983-10-04 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and indomethacin |
| US4404211A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and flurbiprofen |
| US4404208A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| AU565634B2 (en) * | 1982-06-30 | 1987-09-24 | E.I. Du Pont De Nemours And Company | Synergistic compositions of nalbuphine and non-narcotic analgesic compounds |
| US4402962A (en) * | 1982-06-30 | 1983-09-06 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and 4,5-bis(4-methoxyphenyl)-2-(trifluoromethylsulfonyl)-1H-imidazole |
| US4656177A (en) * | 1982-07-22 | 1987-04-07 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| AT389226B (de) * | 1982-07-22 | 1989-11-10 | Richardson Vicks Inc | Verfahren zur herstellung einer analgetischen und antiinflammatorischen pharmazeutischen zubereitung |
| US4777174A (en) * | 1982-07-22 | 1988-10-11 | Analgesic Associates | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same |
| US4600579A (en) * | 1983-06-07 | 1986-07-15 | Mallinckrodt, Inc. | N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same |
| US4722928A (en) * | 1985-12-02 | 1988-02-02 | E. I. Du Pont De Nemours And Company | N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes |
| DK0566709T5 (da) | 1991-09-06 | 2009-05-18 | Ortho Mcneil Janssen Pharm | Præparat indeholdende et tramadolmateriale og acetaminophen og anvendelse deraf |
| US5558876A (en) * | 1995-03-29 | 1996-09-24 | Alcon Laboratories, Inc. | Topical ophthalmic acidic drug formulations |
| US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
| US6361794B1 (en) | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
| US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| EP1685839B8 (en) | 1997-12-22 | 2013-06-26 | Euro-Celtique S.A. | Pharmaceutical oral dosage form comprising a combination of an opioid agonist and opioid antagonist |
| GEP20053614B (en) * | 2000-02-08 | 2005-09-26 | Euro Celtique Sa | Compositions for Oral Administration Containing Opioid Agonist |
| CA2446550C (en) | 2001-05-11 | 2012-03-06 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
| JP4256259B2 (ja) | 2001-07-18 | 2009-04-22 | ユーロ−セルティーク エス．エイ． | オキシコドン及びナロキソンの医薬配合物 |
| PT1414451E (pt) | 2001-08-06 | 2009-07-31 | Euro Celtique Sa | Formulações agonistas de opióides com antagonista libertável e sequestrado |
| US20030157168A1 (en) | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
| US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
| ES2627298T3 (es) | 2002-04-05 | 2017-07-27 | Mundipharma Pharmaceuticals S.L. | Preparación farmacéutica que contiene oxicodona y naloxona |
| ES2677769T3 (es) | 2002-09-20 | 2018-08-06 | Alpharma Pharmaceuticals Llc | Subunidad secuestrante y composiciones y procedimientos relacionados |
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
| TWI347201B (en) | 2003-04-21 | 2011-08-21 | Euro Celtique Sa | Pharmaceutical products,uses thereof and methods for preparing the same |
| EP1604666A1 (en) | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
| EP1702558A1 (en) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
| HUE053838T2 (hu) | 2005-08-24 | 2021-07-28 | Endo Pharmaceuticals Inc | Nyújtott felszabadulású nabulfin-készítmények |
| US8394812B2 (en) | 2005-08-24 | 2013-03-12 | Penwest Pharmaceuticals Co. | Sustained release formulations of nalbuphine |
| RU2445077C2 (ru) | 2006-06-19 | 2012-03-20 | АЛФАРМА, Инк. | Фармацевтические композиции |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| RS58240B1 (sr) | 2009-03-10 | 2019-03-29 | Euro Celtique Sa | Farmaceutske kombinacije sa trenutnim oslobađanjem koje obuhvataju oksikodon i nalokson |
| WO2015011189A1 (en) | 2013-07-23 | 2015-01-29 | Euro-Celtique S.A. | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
| SI3639828T1 (sl) | 2013-12-24 | 2022-04-29 | Virginia Commonwealth University | Uporaba oksigeniranih holesterol sulfatov (OCS) za zdravljenje akutne odpovedi jeter |
| JOP20190094A1 (ar) * | 2016-10-27 | 2019-04-25 | Broad Inst Inc | مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh) |
| WO2019070917A1 (en) * | 2017-10-03 | 2019-04-11 | The Schepens Eye Research Institute, Inc. | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE DEGENERATION OF RETINAL PIGMENT EPITHELIUM AND METHODS USING SAME |
| CN113164469A (zh) * | 2018-09-03 | 2021-07-23 | 雅各生技有限公司 | 双那布扶林己二酸酯和乙酰胺酚的药物制剂及治疗疼痛的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL26896A (en) * | 1966-01-19 | 1970-11-30 | Endo Lab | 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones |
| US4029798A (en) * | 1975-06-02 | 1977-06-14 | Sumitomo Chemical Company, Limited | Analgetic composition |
| JPS5946205B2 (ja) * | 1976-01-01 | 1984-11-10 | 科研製薬株式会社 | ベンゾイル誘導体を有効成分とする消炎鎮痛剤 |
-
1979
- 1979-05-18 US US06/040,281 patent/US4237140A/en not_active Expired - Lifetime
-
1980
- 1980-05-13 NZ NZ193695A patent/NZ193695A/en unknown
- 1980-05-13 AU AU58351/80A patent/AU529764B2/en not_active Ceased
- 1980-05-15 DE DE8080102696T patent/DE3061597D1/de not_active Expired
- 1980-05-15 CA CA000352011A patent/CA1139671A/en not_active Expired
- 1980-05-15 EP EP80102696A patent/EP0019282B1/en not_active Expired
- 1980-05-16 IE IE1019/80A patent/IE49988B1/en not_active IP Right Cessation
- 1980-05-16 ZA ZA00802916A patent/ZA802916B/xx unknown
- 1980-05-16 PH PH24035A patent/PH15265A/en unknown
- 1980-05-16 IL IL60095A patent/IL60095A/xx unknown
- 1980-05-16 HU HU80801223A patent/HU178867B/hu not_active IP Right Cessation
- 1980-05-17 JP JP6469980A patent/JPS55154917A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3061597D1 (en) | 1983-02-17 |
| EP0019282A1 (en) | 1980-11-26 |
| CA1139671A (en) | 1983-01-18 |
| ZA802916B (en) | 1981-12-30 |
| JPH0144684B2 (cg-RX-API-DMAC10.html) | 1989-09-29 |
| AU529764B2 (en) | 1983-06-16 |
| AU5835180A (en) | 1980-11-20 |
| IE49988B1 (en) | 1986-01-22 |
| JPS55154917A (en) | 1980-12-02 |
| IL60095A0 (en) | 1980-07-31 |
| PH15265A (en) | 1982-11-02 |
| US4237140A (en) | 1980-12-02 |
| IE801019L (en) | 1980-11-18 |
| NZ193695A (en) | 1984-05-31 |
| HU178867B (en) | 1982-07-28 |
| EP0019282B1 (en) | 1983-01-12 |
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