IL58328A0 - Basic ethers, pharmaceutical prepations containing these and processes for their preparation - Google Patents
Basic ethers, pharmaceutical prepations containing these and processes for their preparationInfo
- Publication number
- IL58328A0 IL58328A0 IL58328A IL5832879A IL58328A0 IL 58328 A0 IL58328 A0 IL 58328A0 IL 58328 A IL58328 A IL 58328A IL 5832879 A IL5832879 A IL 5832879A IL 58328 A0 IL58328 A0 IL 58328A0
- Authority
- IL
- Israel
- Prior art keywords
- chr
- compound
- atoms
- alkyl
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
For the Contracting States : BE, CH, DE, FR, GB, IT, NL, SE 1. Basic ethers of the general formula I see diagramm : EP0009683,P12,F1 wherein G is an unsubstituted phenyl oder benzyl group or a phenyl or benzyl group which is monosubstituted or disubstituted by halogen or is alkyl with 1-6 C atoms, Z is 1-imidazolyl or 2-methyl-1-imidazolyl, A is -CH=CR**1-, -CO-CHR**1-, -CHOH-CHR**1- or -CH2 -CHR**2-, n is 1, 2 or 3, R**1 is H or alkyl with 1-4 C atoms and R**2 is alkyl with 1-4 C atoms, and their physiologically acceptable acid addition salts. For the Contracting State : AT 1. Process for the preparation of basic ethers of the general formula I see diagramm : EP0009683,P13,F1 dans laquelle A is -CH=CR**1-, -CO-CHR**1, -CHOH-CHR**1- or -CH2 -CHR**2-. n is 1, 2 or 3, R**1 is H or alkyl with 1-4 C atoms and R**2 is alkyl with 1-4 C atoms, and their physiologically acceptable acid addition salts, characterized in that a compound of the general formula II R-Q wherein R is the group C-O- see diagramm : EP0009683,P13,F2 and Q is a radical which can be reduced to a group -A-(CH2 )n -Z, and G, Z, A and n have the meaning indicated above, is treated with a reducing agent, or in that a compound which corresponds to the general formula I but in which the hydroxyl group is present in a functionally modified form is treated with a solvolyzing agent with liberation of the hydroxyl group, or in that a compound of the general formula III R-A-(CH2 )n -X wherein X is Cl, Br, I, OH or reactively functionally modified OH and R, A and n have the meaning indicated above, is reacted with a compound of the general H-Z and in that, optionally, a resulting hydroxy compound of the formula I wherein A is -CHOH-CHR**1- is treated with a dehydrating agent and/or a resulting compound of the formula I wherein A is -CH=CR**1-, CO-CHR**1- or -CHOH-CHR**1 is treated with a reducing agent and/or a resulting base of the formula is converted to one of its physiologically acceptable acid addition salts by treatment with an acid.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782842759 DE2842759A1 (en) | 1978-09-30 | 1978-09-30 | BASIC AETHER, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
IL58328A0 true IL58328A0 (en) | 1979-12-30 |
Family
ID=6051039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL58328A IL58328A0 (en) | 1978-09-30 | 1979-09-26 | Basic ethers, pharmaceutical prepations containing these and processes for their preparation |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0009683B1 (en) |
JP (1) | JPS5551043A (en) |
AT (1) | ATE4420T1 (en) |
AU (1) | AU526323B2 (en) |
CA (1) | CA1136635A (en) |
DE (2) | DE2842759A1 (en) |
ES (1) | ES484525A1 (en) |
HU (1) | HU178648B (en) |
IL (1) | IL58328A0 (en) |
YU (1) | YU237579A (en) |
ZA (1) | ZA795181B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0095115A1 (en) * | 1982-05-26 | 1983-11-30 | Bayer Ag | Substituted diphenyl ethers |
FR2645019A1 (en) * | 1989-03-30 | 1990-10-05 | Fournier Innovation Synergie | |
FR2718450B1 (en) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | New erythromycin derivatives, their preparation process and their use as drugs. |
US6297239B1 (en) | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD9565A (en) * | ||||
US2765307A (en) * | 1953-02-11 | 1956-10-02 | Rohm & Haas | Hydroxyamines |
GB787308A (en) * | 1955-02-25 | 1957-12-04 | Ferrosan Ab | Substituted aminopropiophenones |
US3833603A (en) * | 1970-04-09 | 1974-09-03 | Bayer Ag | 1-(alpha,alpha-disubstituted 4-phenoxy-benzyl)imidazoles |
IE40911B1 (en) * | 1974-04-11 | 1979-09-12 | Schering Ag | Imidazole derivatives and process for their manufacture |
DE2523565A1 (en) * | 1975-05-28 | 1977-04-07 | Merck Patent Gmbh | Araliphatic amines and derivs. - with antiphlogistic, hypolipaemic, analgesic, antipyretic, antithrombotic, etc., activity |
-
1978
- 1978-09-30 DE DE19782842759 patent/DE2842759A1/en not_active Withdrawn
-
1979
- 1979-09-12 EP EP79103417A patent/EP0009683B1/en not_active Expired
- 1979-09-12 AT AT79103417T patent/ATE4420T1/en not_active IP Right Cessation
- 1979-09-12 DE DE7979103417T patent/DE2966050D1/en not_active Expired
- 1979-09-20 YU YU02375/79A patent/YU237579A/en unknown
- 1979-09-25 CA CA000336319A patent/CA1136635A/en not_active Expired
- 1979-09-26 IL IL58328A patent/IL58328A0/en unknown
- 1979-09-27 AU AU51265/79A patent/AU526323B2/en not_active Ceased
- 1979-09-27 ES ES484525A patent/ES484525A1/en not_active Expired
- 1979-09-28 HU HU79ME2300A patent/HU178648B/en unknown
- 1979-09-28 JP JP12426779A patent/JPS5551043A/en active Pending
- 1979-09-28 ZA ZA00795181A patent/ZA795181B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP0009683A1 (en) | 1980-04-16 |
AU526323B2 (en) | 1983-01-06 |
ES484525A1 (en) | 1980-06-16 |
DE2966050D1 (en) | 1983-09-15 |
ATE4420T1 (en) | 1983-08-15 |
ZA795181B (en) | 1980-12-31 |
HU178648B (en) | 1982-06-28 |
DE2842759A1 (en) | 1980-04-10 |
JPS5551043A (en) | 1980-04-14 |
CA1136635A (en) | 1982-11-30 |
YU237579A (en) | 1983-02-28 |
EP0009683B1 (en) | 1983-08-10 |
AU5126579A (en) | 1980-04-17 |
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