AU526323B2 - Basic ethers - Google Patents

Basic ethers

Info

Publication number
AU526323B2
AU526323B2 AU51265/79A AU5126579A AU526323B2 AU 526323 B2 AU526323 B2 AU 526323B2 AU 51265/79 A AU51265/79 A AU 51265/79A AU 5126579 A AU5126579 A AU 5126579A AU 526323 B2 AU526323 B2 AU 526323B2
Authority
AU
Australia
Prior art keywords
chr
compound
atoms
alkyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU51265/79A
Other versions
AU5126579A (en
Inventor
Joachim Gante
Hans-Adolf Kurmeier
Dieter Orth
Helmut Prucher
Volkmar Rudolph
Helmut Wahlig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU5126579A publication Critical patent/AU5126579A/en
Application granted granted Critical
Publication of AU526323B2 publication Critical patent/AU526323B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

For the Contracting States : BE, CH, DE, FR, GB, IT, NL, SE 1. Basic ethers of the general formula I see diagramm : EP0009683,P12,F1 wherein G is an unsubstituted phenyl oder benzyl group or a phenyl or benzyl group which is monosubstituted or disubstituted by halogen or is alkyl with 1-6 C atoms, Z is 1-imidazolyl or 2-methyl-1-imidazolyl, A is -CH=CR**1-, -CO-CHR**1-, -CHOH-CHR**1- or -CH2 -CHR**2-, n is 1, 2 or 3, R**1 is H or alkyl with 1-4 C atoms and R**2 is alkyl with 1-4 C atoms, and their physiologically acceptable acid addition salts. For the Contracting State : AT 1. Process for the preparation of basic ethers of the general formula I see diagramm : EP0009683,P13,F1 dans laquelle A is -CH=CR**1-, -CO-CHR**1, -CHOH-CHR**1- or -CH2 -CHR**2-. n is 1, 2 or 3, R**1 is H or alkyl with 1-4 C atoms and R**2 is alkyl with 1-4 C atoms, and their physiologically acceptable acid addition salts, characterized in that a compound of the general formula II R-Q wherein R is the group C-O- see diagramm : EP0009683,P13,F2 and Q is a radical which can be reduced to a group -A-(CH2 )n -Z, and G, Z, A and n have the meaning indicated above, is treated with a reducing agent, or in that a compound which corresponds to the general formula I but in which the hydroxyl group is present in a functionally modified form is treated with a solvolyzing agent with liberation of the hydroxyl group, or in that a compound of the general formula III R-A-(CH2 )n -X wherein X is Cl, Br, I, OH or reactively functionally modified OH and R, A and n have the meaning indicated above, is reacted with a compound of the general H-Z and in that, optionally, a resulting hydroxy compound of the formula I wherein A is -CHOH-CHR**1- is treated with a dehydrating agent and/or a resulting compound of the formula I wherein A is -CH=CR**1-, CO-CHR**1- or -CHOH-CHR**1 is treated with a reducing agent and/or a resulting base of the formula is converted to one of its physiologically acceptable acid addition salts by treatment with an acid.
AU51265/79A 1978-09-30 1979-09-27 Basic ethers Ceased AU526323B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE28427590 1978-09-30
DE19782842759 DE2842759A1 (en) 1978-09-30 1978-09-30 BASIC AETHER, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number Publication Date
AU5126579A AU5126579A (en) 1980-04-17
AU526323B2 true AU526323B2 (en) 1983-01-06

Family

ID=6051039

Family Applications (1)

Application Number Title Priority Date Filing Date
AU51265/79A Ceased AU526323B2 (en) 1978-09-30 1979-09-27 Basic ethers

Country Status (11)

Country Link
EP (1) EP0009683B1 (en)
JP (1) JPS5551043A (en)
AT (1) ATE4420T1 (en)
AU (1) AU526323B2 (en)
CA (1) CA1136635A (en)
DE (2) DE2842759A1 (en)
ES (1) ES484525A1 (en)
HU (1) HU178648B (en)
IL (1) IL58328A0 (en)
YU (1) YU237579A (en)
ZA (1) ZA795181B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0095115A1 (en) * 1982-05-26 1983-11-30 Bayer Ag Substituted diphenyl ethers
FR2645019A1 (en) * 1989-03-30 1990-10-05 Fournier Innovation Synergie
FR2718450B1 (en) * 1994-04-08 1997-01-10 Roussel Uclaf New erythromycin derivatives, their preparation process and their use as drugs.
US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD9565A (en) *
US2765307A (en) * 1953-02-11 1956-10-02 Rohm & Haas Hydroxyamines
GB787308A (en) * 1955-02-25 1957-12-04 Ferrosan Ab Substituted aminopropiophenones
US3833603A (en) * 1970-04-09 1974-09-03 Bayer Ag 1-(alpha,alpha-disubstituted 4-phenoxy-benzyl)imidazoles
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
DE2523565A1 (en) * 1975-05-28 1977-04-07 Merck Patent Gmbh Araliphatic amines and derivs. - with antiphlogistic, hypolipaemic, analgesic, antipyretic, antithrombotic, etc., activity

Also Published As

Publication number Publication date
YU237579A (en) 1983-02-28
IL58328A0 (en) 1979-12-30
JPS5551043A (en) 1980-04-14
DE2966050D1 (en) 1983-09-15
ATE4420T1 (en) 1983-08-15
DE2842759A1 (en) 1980-04-10
HU178648B (en) 1982-06-28
CA1136635A (en) 1982-11-30
EP0009683A1 (en) 1980-04-16
AU5126579A (en) 1980-04-17
EP0009683B1 (en) 1983-08-10
ES484525A1 (en) 1980-06-16
ZA795181B (en) 1980-12-31

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