IL57690A - Process for the production of n-cyano-n'-methyl-n"-(2-((5-methyl-4-imidazolyl)methylthio)ethyl)guanidine
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Process for the production of n-cyano-n'-methyl-n"-(2-((5-methyl-4-imidazolyl)methylthio)ethyl)guanidine
Info
Publication number
IL57690A
IL57690AIL57690AIL5769076AIL57690AIL 57690 AIL57690 AIL 57690AIL 57690 AIL57690 AIL 57690AIL 5769076 AIL5769076 AIL 5769076AIL 57690 AIL57690 AIL 57690A
Authority
IL
Israel
Prior art keywords
methyl
give
production
guanidine
methylthio
Prior art date
Application number
IL57690A
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/690,476external-prioritypatent/US4063023A/en
Application filed by Smithkline CorpfiledCriticalSmithkline Corp
Priority claimed from IL50147Aexternal-prioritypatent/IL50147A/en
Publication of IL57690ApublicationCriticalpatent/IL57690A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Claims (1)
1. CLAIMS A process for the production of guanidine which comprises reducing a ic acid ester of the formula wherein R is methyl and is lower using an alkali metal or calcium in liquid ammonia with an additional proton to give the intermediate of Formula wherein R is as defined which is reacted with cysteamine under reflux in acetic acid to give and reacting the latter with thiourea to give the desired A modification of the process of claim wherein the intermediate imidazol is added to a solution of carbonate to give which is dissolved in a suitable to which there is added to give the desired Process for the production of to whenever obtained by a process according to any of claims 1 to insufficientOCRQuality
IL57690A1975-08-201976-07-27Process for the production of n-cyano-n'-methyl-n"-(2-((5-methyl-4-imidazolyl)methylthio)ethyl)guanidine
IL57690A
(en)