IL57030A - Cerebral therapeutic compositions containing 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine 3,5-dicarboxylic acid 3-(beta-methoxyethyl ester)-5-(isopropyl ester) - Google Patents
Cerebral therapeutic compositions containing 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine 3,5-dicarboxylic acid 3-(beta-methoxyethyl ester)-5-(isopropyl ester)Info
- Publication number
- IL57030A IL57030A IL57030A IL5703079A IL57030A IL 57030 A IL57030 A IL 57030A IL 57030 A IL57030 A IL 57030A IL 5703079 A IL5703079 A IL 5703079A IL 57030 A IL57030 A IL 57030A
- Authority
- IL
- Israel
- Prior art keywords
- ester
- nitrophenyl
- dihydro
- pyridine
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2815578A DE2815578C2 (de) | 1978-04-11 | 1978-04-11 | Neue pharmazeutische Verwendung von Nimodipin |
Publications (2)
Publication Number | Publication Date |
---|---|
IL57030A0 IL57030A0 (en) | 1979-07-25 |
IL57030A true IL57030A (en) | 1982-09-30 |
Family
ID=6036687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL57030A IL57030A (en) | 1978-04-11 | 1979-04-09 | Cerebral therapeutic compositions containing 1,4-dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-pyridine 3,5-dicarboxylic acid 3-(beta-methoxyethyl ester)-5-(isopropyl ester) |
Country Status (27)
Country | Link |
---|---|
US (1) | US4406906A (fr) |
EP (1) | EP0004650B1 (fr) |
JP (3) | JPS54135776A (fr) |
AT (1) | AT383271B (fr) |
AU (1) | AU532623B2 (fr) |
BE (1) | BE875457A (fr) |
CA (1) | CA1140853A (fr) |
CH (3) | CH649921A5 (fr) |
DE (2) | DE2815578C2 (fr) |
DK (1) | DK150479A (fr) |
ES (1) | ES479474A1 (fr) |
FI (1) | FI791162A (fr) |
FR (1) | FR2422402A1 (fr) |
GB (1) | GB2018134A (fr) |
GR (1) | GR71463B (fr) |
HK (1) | HK59188A (fr) |
IE (1) | IE51651B1 (fr) |
IL (1) | IL57030A (fr) |
IT (1) | IT1062201B (fr) |
LU (2) | LU88273I2 (fr) |
NL (2) | NL7902778A (fr) |
NO (1) | NO791009L (fr) |
NZ (1) | NZ190133A (fr) |
PH (1) | PH15574A (fr) |
SE (1) | SE447248B (fr) |
SG (1) | SG18688G (fr) |
ZA (1) | ZA791728B (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3142853A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung |
EP0078430B2 (fr) * | 1981-10-29 | 1993-02-10 | Bayer Ag | Procédé de fabrication de préparations pharmaceutiques solides à libération rapide de dihydropyridines |
JPS58172312A (ja) * | 1982-04-02 | 1983-10-11 | Toa Eiyou Kagaku Kogyo Kk | ニフエジピン外用剤 |
JPS58177916A (ja) * | 1982-04-13 | 1983-10-18 | Kowa Co | 外用剤 |
DE3307422A1 (de) * | 1983-03-03 | 1984-09-06 | Bayer Ag, 5090 Leverkusen | Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen |
US4690935A (en) * | 1983-03-31 | 1987-09-01 | Wayne State University | Inhibition of tumor growth and metastasis with calcium channel blocker compounds |
DE3316510A1 (de) * | 1983-05-06 | 1984-11-08 | Bayer Ag | Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen |
DE3339236A1 (de) * | 1983-10-28 | 1985-05-09 | Bayer Ag | Arzneimittelzubereitung |
DE4342196A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Neue 4-Phenyl-substituierte 1,4-Dihydropyridine |
FR2568773B1 (fr) * | 1984-08-10 | 1989-03-03 | Sandoz Lab | Nouvelles compositions pharmaceutiques administrables par voie nasale |
EP0175671A1 (fr) * | 1984-08-23 | 1986-03-26 | Kuhlemann & Co. | Préparation pharmaceutique et procédé pour l'administration de cette préparation pharmaceutique |
DE3438830A1 (de) * | 1984-10-23 | 1986-04-30 | Rentschler Arzneimittel | Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung |
DE3544692A1 (de) * | 1985-12-18 | 1987-06-19 | Bayer Ag | Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung |
US4758669A (en) * | 1986-05-05 | 1988-07-19 | Radiation Oncology Center Research And Development Corporation | 4-(nitrone aryl) dihydropyridines |
US5401759A (en) * | 1989-11-16 | 1995-03-28 | Miles Inc. | Nimodipine enhanced growth and vascularization of neural grafts |
RU1804845C (ru) * | 1991-02-15 | 1993-03-30 | Институт Органического Синтеза Латвийской Ан | Ноотропное вещество |
JP2793410B2 (ja) * | 1991-04-22 | 1998-09-03 | インターナショナル・ビジネス・マシーンズ・コーポレイション | ウェブ駆動装置及びテープ駆動装置 |
US5438144A (en) * | 1991-07-30 | 1995-08-01 | Troponwerke Gmbh & Co. Kg | Use of 1,4-dihydropyridines in diabetes |
DE4130173A1 (de) * | 1991-09-11 | 1993-03-18 | Bayer Ag | Pharmazeutische zubereitungen mit einer speziellen kristallmodifikation des 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarbonsaeure-isopropyl-(2-methoxyethyl)-esters |
DE4133257A1 (de) * | 1991-10-08 | 1993-04-15 | Bayer Ag | N-methyl-nimodipin, verfahren zu seiner herstellung und seine verwendung als zerebraltherapeutikum |
IT1255792B (it) * | 1992-08-05 | 1995-11-16 | Bayer Italia Spa | Composizioni farmaceutiche per la somministrazione orale di diidropiridine in forma di bevanda |
US6001857A (en) * | 1992-10-30 | 1999-12-14 | Bayer Aktiengesellschaft | Heterocyclyl substituted dihydropyridines |
ES2096179T3 (es) * | 1992-10-30 | 1997-03-01 | Bayer Ag | Dihidropiridinas sustituidas en la posicion 4 con un heterociclilfenilo. |
DE4236707A1 (de) * | 1992-10-30 | 1994-05-05 | Bayer Ag | 4-Heterocyclyl substituierte Dihydropyridine |
SE9203857D0 (sv) * | 1992-12-22 | 1992-12-22 | Astra Ab | Use of an enantiomeric dihydropyridine |
DE59410255D1 (de) | 1993-12-10 | 2003-04-17 | Bayer Ag | Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität |
DE4342193A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Arylsubstituierte Alkoxycarbonyl-1,4-dihydropyridin-5-carbonsäureester |
EE03192B1 (et) * | 1993-12-10 | 1999-06-15 | Bayer Aktiengesellschaft | Isopropüül-(2-metoksüetüül)-4-(2-kloro-3-tsüanofenüül)-1,4-dihüdro-2,6-dimetüülpüri diin-3,5-dikarboksülaat, selle enantiomeerid ja vaheühend, meetodid nimetatud ühendite valmistamiseks ja kasutamine |
DE4430094A1 (de) * | 1994-08-25 | 1996-02-29 | Bayer Ag | Verwendung von 3,5-Dicarbonsäureester-1,4-Dihydropyridinen als Arzneimittel |
US6078481A (en) * | 1998-06-08 | 2000-06-20 | Imation Corp. | Tape storage cartridge having two-level tape path |
AR027152A1 (es) * | 2000-12-29 | 2003-03-12 | Osmotica Argentina S A | Composicion farmaceutica para el tratamiento de la enfermedad cerebrovascular cognitiva. |
DE10142417A1 (de) * | 2001-08-31 | 2003-03-20 | Molecular And Clinical Drug Re | Arzneimittel |
EP2316468A1 (fr) | 2002-02-22 | 2011-05-04 | Shire LLC | Système de distribution et méthodes de protection et d'administration de dextroamphetamine |
JP2009511594A (ja) * | 2005-10-14 | 2009-03-19 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | ニモジピンの液体製薬学的組成物 |
US8748648B2 (en) * | 2007-09-06 | 2014-06-10 | Nektar Therapeutics | Oligomer-calcium channel blocker conjugates |
US9737478B2 (en) * | 2009-09-28 | 2017-08-22 | National Institutes of Health (NIH), U.S. Dept. of Health and Human Services (DHHS), The United States of America NIH Division of Extramural Inventions and Technology Resources (DEITR) | Treatment of malaria |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2117573C3 (de) * | 1971-04-10 | 1978-07-27 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel |
DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
GB1430961A (en) * | 1972-01-22 | 1976-04-07 | Yamanouchi Pharma Co Ltd | 1-substituted-1,4-dihyddrypyridine derivatives |
GB1455502A (en) * | 1973-02-20 | 1976-11-10 | Yamanouchi Pharma Co Ltd | 1,4-dihydropyridine derivatives |
-
1978
- 1978-04-11 DE DE2815578A patent/DE2815578C2/de not_active Expired
-
1979
- 1979-03-27 NO NO791009A patent/NO791009L/no unknown
- 1979-03-30 DE DE7979100968T patent/DE2967573D1/de not_active Expired
- 1979-03-30 EP EP79100968A patent/EP0004650B1/fr not_active Expired
- 1979-03-30 LU LU88273C patent/LU88273I2/xx unknown
- 1979-04-05 GB GB7911998A patent/GB2018134A/en not_active Withdrawn
- 1979-04-06 GR GR58827A patent/GR71463B/el unknown
- 1979-04-09 IL IL57030A patent/IL57030A/xx unknown
- 1979-04-09 NL NL7902778A patent/NL7902778A/xx active Search and Examination
- 1979-04-09 JP JP4212979A patent/JPS54135776A/ja active Granted
- 1979-04-09 CH CH5581/83A patent/CH649921A5/de not_active IP Right Cessation
- 1979-04-09 CH CH5580/83A patent/CH649468A5/de not_active IP Right Cessation
- 1979-04-09 CH CH332879A patent/CH640734A5/de not_active IP Right Cessation
- 1979-04-09 LU LU81133A patent/LU81133A1/de unknown
- 1979-04-09 AU AU45835/79A patent/AU532623B2/en not_active Expired
- 1979-04-09 NZ NZ190133A patent/NZ190133A/en unknown
- 1979-04-09 AT AT0262179A patent/AT383271B/de not_active IP Right Cessation
- 1979-04-09 IT IT21692/79A patent/IT1062201B/it active
- 1979-04-09 FI FI791162A patent/FI791162A/fi not_active Application Discontinuation
- 1979-04-10 CA CA000325229A patent/CA1140853A/fr not_active Expired
- 1979-04-10 SE SE7903186A patent/SE447248B/sv not_active IP Right Cessation
- 1979-04-10 ES ES479474A patent/ES479474A1/es not_active Expired
- 1979-04-10 DK DK150479A patent/DK150479A/da not_active IP Right Cessation
- 1979-04-10 PH PH22376A patent/PH15574A/en unknown
- 1979-04-10 FR FR7909029A patent/FR2422402A1/fr active Granted
- 1979-04-10 BE BE0/194506A patent/BE875457A/fr not_active IP Right Cessation
- 1979-04-10 ZA ZA791728A patent/ZA791728B/xx unknown
- 1979-08-08 IE IE756/79A patent/IE51651B1/en not_active IP Right Cessation
-
1982
- 1982-02-05 US US06/346,319 patent/US4406906A/en not_active Expired - Lifetime
-
1983
- 1983-06-01 JP JP58095893A patent/JPS591412A/ja active Pending
- 1983-06-01 JP JP58095894A patent/JPS58219117A/ja active Pending
-
1988
- 1988-03-23 SG SG186/88A patent/SG18688G/en unknown
- 1988-08-04 HK HK591/88A patent/HK59188A/xx not_active IP Right Cessation
-
1993
- 1993-05-24 NL NL930034C patent/NL930034I2/nl unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed |