ES2096179T3 - Dihidropiridinas sustituidas en la posicion 4 con un heterociclilfenilo. - Google Patents
Dihidropiridinas sustituidas en la posicion 4 con un heterociclilfenilo.Info
- Publication number
- ES2096179T3 ES2096179T3 ES93116862T ES93116862T ES2096179T3 ES 2096179 T3 ES2096179 T3 ES 2096179T3 ES 93116862 T ES93116862 T ES 93116862T ES 93116862 T ES93116862 T ES 93116862T ES 2096179 T3 ES2096179 T3 ES 2096179T3
- Authority
- ES
- Spain
- Prior art keywords
- dihydropyridines
- substituted
- heterocyclophenyl
- heterociclilfenilo
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DIHIDROPIRIDINAS SUSTITUIDAS POR 4-HETEROCICLOFENILO SON ELABORADAS, MEDIANTE LA TRANSFORMACION DE UN ALDEHIDO APROPIADO CON AMINOESTER Y BETA-CETOESTERES, O LOS SUSTITUYENTES HETEROCICLICOS DEL 4-FENILO REPRESENTADAS A TRAVES AMIDINA O HIDRACIDA CORRESPONDIENTE AL CIERRE DEL ANILLO, O ACIDOS DIHIDROPIRIDONCARBOXILICOS, QUE SON SUSTITUIDOS DE FORMA HETEROCICLICA SE ESTERIFICAN CON ALCOHOLES CORRESPONDIENTES. LAS DIHIDROPIRIDINAS SUSTITUIDAS POR 4HETEROCICLOFENIL PUEDEN SER UTILIZADAS EN MEDICAMENTOS, EN PARTICULAR PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19924236706 DE4236706A1 (de) | 1992-10-30 | 1992-10-30 | 4-Heterocyclophenyl substituierte Dihydropyridine |
DE19924236705 DE4236705A1 (de) | 1992-10-30 | 1992-10-30 | 4-Pyrrolylphenyl substituierte Dihydropyridine |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2096179T3 true ES2096179T3 (es) | 1997-03-01 |
Family
ID=25919983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93116862T Expired - Lifetime ES2096179T3 (es) | 1992-10-30 | 1993-10-19 | Dihidropiridinas sustituidas en la posicion 4 con un heterociclilfenilo. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5403849A (es) |
EP (1) | EP0595164B1 (es) |
JP (1) | JPH06199849A (es) |
AT (1) | ATE146788T1 (es) |
CA (1) | CA2109342A1 (es) |
DE (1) | DE59304885D1 (es) |
DK (1) | DK0595164T3 (es) |
ES (1) | ES2096179T3 (es) |
GR (1) | GR3022166T3 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4342196A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Neue 4-Phenyl-substituierte 1,4-Dihydropyridine |
EP0657432B1 (de) | 1993-12-10 | 2003-03-12 | Bayer Ag | Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität |
US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
KR101369207B1 (ko) | 2007-04-11 | 2014-03-04 | 한국과학기술원 | (s)-(-)-펠로디핀의 제조방법 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670824C3 (de) * | 1967-03-20 | 1978-08-03 | Bayer Ag, 5090 Leverkusen | 1,4-Dihydropyridin-33-dicarbonsäurealkylester |
DE2815578C2 (de) * | 1978-04-11 | 1986-01-16 | Bayer Ag, 5090 Leverkusen | Neue pharmazeutische Verwendung von Nimodipin |
DE2935451A1 (de) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel |
DE3208628A1 (de) * | 1982-03-10 | 1983-09-22 | Bayer Ag, 5090 Leverkusen | Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE3239273A1 (de) * | 1982-10-23 | 1984-04-26 | Bayer Ag, 5090 Leverkusen | Tetrahydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
US4656181A (en) * | 1982-11-24 | 1987-04-07 | Cermol S.A. | Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same |
US4590276A (en) * | 1984-10-01 | 1986-05-20 | Merck & Co., Inc. | Process for the preparation of cyclopropyl pyridine compounds useful as calcium channel blockers |
DE3816361A1 (de) * | 1987-05-18 | 1988-12-08 | Byk Gulden Lomberg Chem Fab | 1,4-dihydropyridindicarbonsaeure-(-)-menthylester |
IL92646A0 (en) * | 1988-12-15 | 1990-08-31 | Erba Carlo Spa | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines,their preparation and pharmaceutical compositions containing them |
DE4125271A1 (de) * | 1991-07-31 | 1993-02-11 | Bayer Ag | Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester |
-
1993
- 1993-10-19 ES ES93116862T patent/ES2096179T3/es not_active Expired - Lifetime
- 1993-10-19 EP EP93116862A patent/EP0595164B1/de not_active Expired - Lifetime
- 1993-10-19 DE DE59304885T patent/DE59304885D1/de not_active Expired - Fee Related
- 1993-10-19 AT AT93116862T patent/ATE146788T1/de active
- 1993-10-19 DK DK93116862.9T patent/DK0595164T3/da active
- 1993-10-22 US US08/141,837 patent/US5403849A/en not_active Expired - Fee Related
- 1993-10-27 JP JP5289864A patent/JPH06199849A/ja active Pending
- 1993-10-27 CA CA002109342A patent/CA2109342A1/en not_active Abandoned
-
1996
- 1996-12-28 GR GR960403446T patent/GR3022166T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3022166T3 (en) | 1997-03-31 |
EP0595164A1 (de) | 1994-05-04 |
ATE146788T1 (de) | 1997-01-15 |
DK0595164T3 (da) | 1997-05-26 |
US5403849A (en) | 1995-04-04 |
DE59304885D1 (de) | 1997-02-06 |
EP0595164B1 (de) | 1996-12-27 |
CA2109342A1 (en) | 1994-05-01 |
JPH06199849A (ja) | 1994-07-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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